Live attenuated varicella vaccine: the KMcC strain in healthy children
The KMcC strain of live, attenuated varicella-zoster virus vaccine was studied in healthy children as a preliminary step toward varicella vaccine studies with this strain in children with leukemia. Forty-three children were immunized: 26 with the 40th passage vaccine and 17 with the 50th passage. St...
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| Veröffentlicht in: | Pediatrics (Evanston) 1983-03, Vol.71 (3), p.307-312 |
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| container_title | Pediatrics (Evanston) |
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| creator | Arbeter, A M Starr, S E Weibel, R E Neff, B J Plotkin, S A |
| description | The KMcC strain of live, attenuated varicella-zoster virus vaccine was studied in healthy children as a preliminary step toward varicella vaccine studies with this strain in children with leukemia. Forty-three children were immunized: 26 with the 40th passage vaccine and 17 with the 50th passage. Studies included surveillance for clinical reactivity, oropharyngeal excretion of vaccine virus, viruria, and viremia. Antibody responses were assayed by fluorescent antibody to membrane antigens and immune adherence hemagglutination. Cell-mediated immune responses were assayed by lymphocyte proliferation to varicella-zoster virus specific antigens. There was 100% seroconversion to the KMcC passage 40 and 50 vaccines (by fluorescent antibody to membrane antigen assay). Every child studied developed in vitro lymphocyte proliferation to varicella-zoster virus antigens. Papular skin lesions, probably vaccine related, occurred in 31% of the 40th passage vaccinees but in only 6% of the 50th passage vaccinees. The 50th passage KMcC strain vaccine is sufficiently immunogenic and safe to initiate clinical studies with leukemia patients. |
| doi_str_mv | 10.1542/peds.71.3.307 |
| format | Article |
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Forty-three children were immunized: 26 with the 40th passage vaccine and 17 with the 50th passage. Studies included surveillance for clinical reactivity, oropharyngeal excretion of vaccine virus, viruria, and viremia. Antibody responses were assayed by fluorescent antibody to membrane antigens and immune adherence hemagglutination. Cell-mediated immune responses were assayed by lymphocyte proliferation to varicella-zoster virus specific antigens. There was 100% seroconversion to the KMcC passage 40 and 50 vaccines (by fluorescent antibody to membrane antigen assay). Every child studied developed in vitro lymphocyte proliferation to varicella-zoster virus antigens. Papular skin lesions, probably vaccine related, occurred in 31% of the 40th passage vaccinees but in only 6% of the 50th passage vaccinees. The 50th passage KMcC strain vaccine is sufficiently immunogenic and safe to initiate clinical studies with leukemia patients.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.71.3.307</identifier><identifier>PMID: 6298698</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Antibodies, Viral - analysis ; Antibody Formation ; Chickenpox - immunology ; Chickenpox - prevention & control ; Child ; Child, Preschool ; Female ; Fluorescent Antibody Technique ; Herpesvirus 3, Human - immunology ; Humans ; Immune Adherence Reaction ; Infant ; Leukemia - complications ; Lymphocyte Activation ; Male ; Vaccination ; Vaccines, Attenuated - administration & dosage ; varicella-zoster virus ; Viral Vaccines - administration & dosage</subject><ispartof>Pediatrics (Evanston), 1983-03, Vol.71 (3), p.307-312</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-1469eedd14bd49353f09109a758126fec903c4f65481720018b47cb2bf3156ee3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6298698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arbeter, A M</creatorcontrib><creatorcontrib>Starr, S E</creatorcontrib><creatorcontrib>Weibel, R E</creatorcontrib><creatorcontrib>Neff, B J</creatorcontrib><creatorcontrib>Plotkin, S A</creatorcontrib><title>Live attenuated varicella vaccine: the KMcC strain in healthy children</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>The KMcC strain of live, attenuated varicella-zoster virus vaccine was studied in healthy children as a preliminary step toward varicella vaccine studies with this strain in children with leukemia. Forty-three children were immunized: 26 with the 40th passage vaccine and 17 with the 50th passage. Studies included surveillance for clinical reactivity, oropharyngeal excretion of vaccine virus, viruria, and viremia. Antibody responses were assayed by fluorescent antibody to membrane antigens and immune adherence hemagglutination. Cell-mediated immune responses were assayed by lymphocyte proliferation to varicella-zoster virus specific antigens. There was 100% seroconversion to the KMcC passage 40 and 50 vaccines (by fluorescent antibody to membrane antigen assay). Every child studied developed in vitro lymphocyte proliferation to varicella-zoster virus antigens. Papular skin lesions, probably vaccine related, occurred in 31% of the 40th passage vaccinees but in only 6% of the 50th passage vaccinees. The 50th passage KMcC strain vaccine is sufficiently immunogenic and safe to initiate clinical studies with leukemia patients.</description><subject>Adolescent</subject><subject>Antibodies, Viral - analysis</subject><subject>Antibody Formation</subject><subject>Chickenpox - immunology</subject><subject>Chickenpox - prevention & control</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fluorescent Antibody Technique</subject><subject>Herpesvirus 3, Human - immunology</subject><subject>Humans</subject><subject>Immune Adherence Reaction</subject><subject>Infant</subject><subject>Leukemia - complications</subject><subject>Lymphocyte Activation</subject><subject>Male</subject><subject>Vaccination</subject><subject>Vaccines, Attenuated - administration & dosage</subject><subject>varicella-zoster virus</subject><subject>Viral Vaccines - administration & dosage</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1Lw0AURQdRaq0uXQpZuUt885WZcSfFqlhxo-thMnkhkTStmUmh_97UFrfCg_sWh8vlEHJNIaNSsLsNliFTNOMZB3VCphSMTgVT8pRMAThNBYA8JxchfAGAkIpNyCRnRudGT8li2WwxcTFiN7iIZbJ1feOxbd34ed90eJ_EGpPXNz9PQuxd0yXj1ejaWO8SXzdt2WN3Sc4q1wa8OuaMfC4eP-bP6fL96WX-sEw9pyamVOQGsSypKEphuOQVmHGvU1JTllfoDXAvqlwKTRUDoLoQyhesqDiVOSKfkdtD76Zffw8Yol014Xduh-shWA1c50zIf0HKlaFS6xFMD6Dv1yH0WNlN36xcv7MU7F6w3Qu2ilpuR8Ejf3MsHooVln_00Sj_AfDodXg</recordid><startdate>198303</startdate><enddate>198303</enddate><creator>Arbeter, A M</creator><creator>Starr, S E</creator><creator>Weibel, R E</creator><creator>Neff, B J</creator><creator>Plotkin, S A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>198303</creationdate><title>Live attenuated varicella vaccine: the KMcC strain in healthy children</title><author>Arbeter, A M ; Starr, S E ; Weibel, R E ; Neff, B J ; Plotkin, S A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c319t-1469eedd14bd49353f09109a758126fec903c4f65481720018b47cb2bf3156ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adolescent</topic><topic>Antibodies, Viral - analysis</topic><topic>Antibody Formation</topic><topic>Chickenpox - immunology</topic><topic>Chickenpox - prevention & control</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fluorescent Antibody Technique</topic><topic>Herpesvirus 3, Human - immunology</topic><topic>Humans</topic><topic>Immune Adherence Reaction</topic><topic>Infant</topic><topic>Leukemia - complications</topic><topic>Lymphocyte Activation</topic><topic>Male</topic><topic>Vaccination</topic><topic>Vaccines, Attenuated - administration & dosage</topic><topic>varicella-zoster virus</topic><topic>Viral Vaccines - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arbeter, A M</creatorcontrib><creatorcontrib>Starr, S E</creatorcontrib><creatorcontrib>Weibel, R E</creatorcontrib><creatorcontrib>Neff, B J</creatorcontrib><creatorcontrib>Plotkin, S A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arbeter, A M</au><au>Starr, S E</au><au>Weibel, R E</au><au>Neff, B J</au><au>Plotkin, S A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Live attenuated varicella vaccine: the KMcC strain in healthy children</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1983-03</date><risdate>1983</risdate><volume>71</volume><issue>3</issue><spage>307</spage><epage>312</epage><pages>307-312</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><abstract>The KMcC strain of live, attenuated varicella-zoster virus vaccine was studied in healthy children as a preliminary step toward varicella vaccine studies with this strain in children with leukemia. Forty-three children were immunized: 26 with the 40th passage vaccine and 17 with the 50th passage. Studies included surveillance for clinical reactivity, oropharyngeal excretion of vaccine virus, viruria, and viremia. Antibody responses were assayed by fluorescent antibody to membrane antigens and immune adherence hemagglutination. Cell-mediated immune responses were assayed by lymphocyte proliferation to varicella-zoster virus specific antigens. There was 100% seroconversion to the KMcC passage 40 and 50 vaccines (by fluorescent antibody to membrane antigen assay). Every child studied developed in vitro lymphocyte proliferation to varicella-zoster virus antigens. Papular skin lesions, probably vaccine related, occurred in 31% of the 40th passage vaccinees but in only 6% of the 50th passage vaccinees. The 50th passage KMcC strain vaccine is sufficiently immunogenic and safe to initiate clinical studies with leukemia patients.</abstract><cop>United States</cop><pmid>6298698</pmid><doi>10.1542/peds.71.3.307</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Antibodies, Viral - analysis Antibody Formation Chickenpox - immunology Chickenpox - prevention & control Child Child, Preschool Female Fluorescent Antibody Technique Herpesvirus 3, Human - immunology Humans Immune Adherence Reaction Infant Leukemia - complications Lymphocyte Activation Male Vaccination Vaccines, Attenuated - administration & dosage varicella-zoster virus Viral Vaccines - administration & dosage |
| title | Live attenuated varicella vaccine: the KMcC strain in healthy children |
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