Congenital Hypofibrinogenemia And Recurrent Placental Abruption

A 32-year-old white woman with a history of 2 episodes of abruptio placentae was found to have congenital hypofibrinogenemia. She had no bleeding difficulties except when pregnant. The patientʼs sisters and her mother also had reduced fibrinogen levels. Results of fibrinogen measurement by clotting...

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Veröffentlicht in:	Obstetrics and gynecology (New York. 1953) 1983-04, Vol.61 (4), p.519-523
Hauptverfasser:	Ness, Paul M, Budzynski, Andrei Z, Olexa, Stephanie A, Rodvien, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Abruptio Placentae - etiology Adult Afibrinogenemia - congenital Afibrinogenemia - diagnosis Afibrinogenemia - genetics Blood Coagulation Tests Female Fibrinogen - analysis Humans Pregnancy Recurrence
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creator	Ness, Paul M Budzynski, Andrei Z Olexa, Stephanie A Rodvien, Robert
description	A 32-year-old white woman with a history of 2 episodes of abruptio placentae was found to have congenital hypofibrinogenemia. She had no bleeding difficulties except when pregnant. The patientʼs sisters and her mother also had reduced fibrinogen levels. Results of fibrinogen measurement by clotting assays and immunologic studies were similar. Immunoelectrophoresis,ʼmolecular weight of fibrinogen chains, cross-linking by factor XIII, carbohydrate staining, and sialic acid quantitation were all normal, suggesting the diagnosis of hypofibrinogenemia rather than dysfibrinogenemia. Fibrinolysis did not account for the reduced fibrinogen level. This case demonstrates that congenital low fibrinogen levels may be associated with placental abruption and that an abnormal fibrinogen molecule is not necessary.
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She had no bleeding difficulties except when pregnant. The patientʼs sisters and her mother also had reduced fibrinogen levels. Results of fibrinogen measurement by clotting assays and immunologic studies were similar. Immunoelectrophoresis,ʼmolecular weight of fibrinogen chains, cross-linking by factor XIII, carbohydrate staining, and sialic acid quantitation were all normal, suggesting the diagnosis of hypofibrinogenemia rather than dysfibrinogenemia. Fibrinolysis did not account for the reduced fibrinogen level. This case demonstrates that congenital low fibrinogen levels may be associated with placental abruption and that an abnormal fibrinogen molecule is not necessary.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 6828283</identifier><language>eng</language><publisher>United States: The American College of Obstetricians and Gynecologists</publisher><subject>Abruptio Placentae - etiology ; Adult ; Afibrinogenemia - congenital ; Afibrinogenemia - diagnosis ; Afibrinogenemia - genetics ; Blood Coagulation Tests ; Female ; Fibrinogen - analysis ; Humans ; Pregnancy ; Recurrence</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1983-04, Vol.61 (4), p.519-523</ispartof><rights>1983 The American College of Obstetricians and Gynecologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6828283$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ness, Paul M</creatorcontrib><creatorcontrib>Budzynski, Andrei Z</creatorcontrib><creatorcontrib>Olexa, Stephanie A</creatorcontrib><creatorcontrib>Rodvien, Robert</creatorcontrib><title>Congenital Hypofibrinogenemia And Recurrent Placental Abruption</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>A 32-year-old white woman with a history of 2 episodes of abruptio placentae was found to have congenital hypofibrinogenemia. 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subjects	Abruptio Placentae - etiology Adult Afibrinogenemia - congenital Afibrinogenemia - diagnosis Afibrinogenemia - genetics Blood Coagulation Tests Female Fibrinogen - analysis Humans Pregnancy Recurrence
title	Congenital Hypofibrinogenemia And Recurrent Placental Abruption
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