Pharmacological, conformational and dynamic properties of cycloleucine-2 analogues of oxytocin and [1-penicillamine]oxytocin

The solid phase syntheses of [2‐cycloleucine]oxytocin and [1‐penicillamine, 2‐cycloleucine]oxytocin are reported. [1‐Penicillamine, 2‐cycloleucine]oxytocin is an oxytocin antagonist exhibiting no in vitro oxytocic activity. In the in vitro oxytocic assay, [1‐penicillamine, 2‐cycloleucine]oxytocin ha...

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Veröffentlicht in:	International Journal of Peptide and Protein Research 1983-01, Vol.21 (1), p.24-34
Hauptverfasser:	HRUBY, VICTOR J., ROCKWAY, TODD W., VISWANATHA, V., CHAN, W.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Assay carbon-13T conformational restrictions in oxytocin Female Hormones - pharmacology Magnetic Resonance Spectroscopy nuclear magnetic resonance Oxytocin - analogs & derivatives Oxytocin - pharmacology oxytocin agonist oxytocin antagonist Protein Conformation Rats Structure-Activity Relationship
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