Cervical ripening with intravaginal prostaglandin E2 gel
Ripening of the cervix by intravaginal application of a prostaglandin-containing gel is evaluated. Thirty patients with an unfavorable cervix needing labor induction were studied in a double-blind, prospective fashion. The prostaglandin gel proved superior to placebo in ripening the cervix (P less t...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1983-04, Vol.61 (4), p.459-462 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | Prins, R P Bolton, R N Mark, 3rd, C Neilson, D R Watson, P |
| description | Ripening of the cervix by intravaginal application of a prostaglandin-containing gel is evaluated. Thirty patients with an unfavorable cervix needing labor induction were studied in a double-blind, prospective fashion. The prostaglandin gel proved superior to placebo in ripening the cervix (P less than .05), reducing induction failures (P less than .025), diminishing the oxytocin dosage necessary for induction (P less than .05), and lowering the rate of cesarean section (.05 less than P less than .1). One hundred fifty additional patients with varying Bishop scores and differing clinical situations were also studied. There were 35 cesarean sections (23.3%), nine failed inductions (6%), a spontaneous labor rate of 46%, and an average Bishop score change of 2.5. Twenty patients with premature rupture of the membranes and an unfavorable cervix received a modified gel containing 2.5 mg of prostaglandin E2. Average Bishop score change was 2.9, and there was a 55% incidence of spontaneous labor. |
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Thirty patients with an unfavorable cervix needing labor induction were studied in a double-blind, prospective fashion. The prostaglandin gel proved superior to placebo in ripening the cervix (P less than .05), reducing induction failures (P less than .025), diminishing the oxytocin dosage necessary for induction (P less than .05), and lowering the rate of cesarean section (.05 less than P less than .1). One hundred fifty additional patients with varying Bishop scores and differing clinical situations were also studied. There were 35 cesarean sections (23.3%), nine failed inductions (6%), a spontaneous labor rate of 46%, and an average Bishop score change of 2.5. Twenty patients with premature rupture of the membranes and an unfavorable cervix received a modified gel containing 2.5 mg of prostaglandin E2. 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Thirty patients with an unfavorable cervix needing labor induction were studied in a double-blind, prospective fashion. The prostaglandin gel proved superior to placebo in ripening the cervix (P less than .05), reducing induction failures (P less than .025), diminishing the oxytocin dosage necessary for induction (P less than .05), and lowering the rate of cesarean section (.05 less than P less than .1). One hundred fifty additional patients with varying Bishop scores and differing clinical situations were also studied. There were 35 cesarean sections (23.3%), nine failed inductions (6%), a spontaneous labor rate of 46%, and an average Bishop score change of 2.5. Twenty patients with premature rupture of the membranes and an unfavorable cervix received a modified gel containing 2.5 mg of prostaglandin E2. Average Bishop score change was 2.9, and there was a 55% incidence of spontaneous labor.</description><subject>Adult</subject><subject>Cervix Uteri - physiology</subject><subject>Dinoprostone</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Fetal Membranes, Premature Rupture - complications</subject><subject>Gels</subject><subject>Humans</subject><subject>Labor, Induced</subject><subject>Labor, Obstetric</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Prostaglandins E - administration & dosage</subject><subject>Random Allocation</subject><issn>0029-7844</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotj81KxDAYRbNQxnH0EYSu3BWSfPnrUsr4AwOz0XVJk29qpM3UpB3x7S3Y1V3cw-XcK7KllFelNkLckNucvyilTFWwIRslNQeQW2JqTJfgbF-kMGIMsSt-wvRZhDgle7FdiEs1pnOebNfb6EMs9rzosL8j1yfbZ7xfc0c-nvfv9Wt5OL681U-HcmRgptI4Y2QrOFp9kpXk6LXXoITmHKhuPRdomULDrQNgmlGuDFBrBNPOoVewI4__u4vE94x5aoaQHfaLDJ7n3BgKhhuQC_iwgnM7oG_GFAabfpv1KvwB3YdNeA</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>Prins, R P</creator><creator>Bolton, R N</creator><creator>Mark, 3rd, C</creator><creator>Neilson, D R</creator><creator>Watson, P</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198304</creationdate><title>Cervical ripening with intravaginal prostaglandin E2 gel</title><author>Prins, R P ; Bolton, R N ; Mark, 3rd, C ; Neilson, D R ; Watson, P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p138t-8c885b42ea7f5952ed7d7364722307bd24ea16e82ac33171026830a8417cced63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Cervix Uteri - physiology</topic><topic>Dinoprostone</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Fetal Membranes, Premature Rupture - complications</topic><topic>Gels</topic><topic>Humans</topic><topic>Labor, Induced</topic><topic>Labor, Obstetric</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Prostaglandins E - administration & dosage</topic><topic>Random Allocation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prins, R P</creatorcontrib><creatorcontrib>Bolton, R N</creatorcontrib><creatorcontrib>Mark, 3rd, C</creatorcontrib><creatorcontrib>Neilson, D R</creatorcontrib><creatorcontrib>Watson, P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prins, R P</au><au>Bolton, R N</au><au>Mark, 3rd, C</au><au>Neilson, D R</au><au>Watson, P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cervical ripening with intravaginal prostaglandin E2 gel</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1983-04</date><risdate>1983</risdate><volume>61</volume><issue>4</issue><spage>459</spage><epage>462</epage><pages>459-462</pages><issn>0029-7844</issn><abstract>Ripening of the cervix by intravaginal application of a prostaglandin-containing gel is evaluated. Thirty patients with an unfavorable cervix needing labor induction were studied in a double-blind, prospective fashion. The prostaglandin gel proved superior to placebo in ripening the cervix (P less than .05), reducing induction failures (P less than .025), diminishing the oxytocin dosage necessary for induction (P less than .05), and lowering the rate of cesarean section (.05 less than P less than .1). One hundred fifty additional patients with varying Bishop scores and differing clinical situations were also studied. There were 35 cesarean sections (23.3%), nine failed inductions (6%), a spontaneous labor rate of 46%, and an average Bishop score change of 2.5. Twenty patients with premature rupture of the membranes and an unfavorable cervix received a modified gel containing 2.5 mg of prostaglandin E2. Average Bishop score change was 2.9, and there was a 55% incidence of spontaneous labor.</abstract><cop>United States</cop><pmid>6572335</pmid><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0029-7844 |
| ispartof | Obstetrics and gynecology (New York. 1953), 1983-04, Vol.61 (4), p.459-462 |
| issn | 0029-7844 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80382835 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Cervix Uteri - physiology Dinoprostone Double-Blind Method Female Fetal Membranes, Premature Rupture - complications Gels Humans Labor, Induced Labor, Obstetric Pregnancy Prospective Studies Prostaglandins E - administration & dosage Random Allocation |
| title | Cervical ripening with intravaginal prostaglandin E2 gel |
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