Nailfold capillary abnormalities in childhood rheumatic diseases
The nailfold capillary patterns of 84 patients with a variety of childhood rheumatic diseases and 34 normal control subjects were observed. Distinctive morphologic abnormalities with capillary dilation and dropout of surrounding structures were noted in two groups: patients with childhood dermatomyo...
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| Veröffentlicht in: | The Journal of pediatrics 1983-03, Vol.102 (3), p.341-346 |
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| container_title | The Journal of pediatrics |
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| creator | Spencer-Green, George Schlesinger, Margaret Bove, Kevin E. Levinson, Joseph E. Schaller, Jane G. Hanson, Virgil Crowe, William E. |
| description | The nailfold capillary patterns of 84 patients with a variety of childhood rheumatic diseases and 34 normal control subjects were observed. Distinctive morphologic abnormalities with capillary dilation and dropout of surrounding structures were noted in two groups: patients with childhood dermatomyositis and with scleroderma (
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| doi_str_mv | 10.1016/S0022-3476(83)80645-3 |
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P<0.001). Among those with scleroderma, capillary abnormalities were found in all nine patients with systemic disease and in none of 10 patients with cutaneous disease only (Fisher's exact
P<0.001). Of 25 patients with dermatomyositis for whom muscle biopsies were available for analysis, abnormal nailfold capillary pattern was found with highest prevalence in patients with two or more specific vascular lesions noted on biopsy (Fisher's exact
P=0.041). Nailfold capillary abnormalities are present in distinct populations of childhood rheumatic diseases, reflect the underlying vasculopathy of childhood dermatomyositis, and may be of diagnostic value in distinguishing localized from systemic scleroderma.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(83)80645-3</identifier><identifier>PMID: 6827403</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adolescent ; Adult ; Arthritis, Juvenile - pathology ; Capillaries - pathology ; Child ; Child, Preschool ; Collagen Diseases - pathology ; Dermatomyositis - pathology ; Female ; Humans ; Male ; Nails ; Scleroderma, Localized - pathology ; Scleroderma, Systemic - pathology ; Skin - blood supply</subject><ispartof>The Journal of pediatrics, 1983-03, Vol.102 (3), p.341-346</ispartof><rights>1982 The C. V. Mosby Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-195999c7b586cb908086c4c046a2da7fe3288b5fdf0da5b4c3973bd0ab69064c3</citedby><cites>FETCH-LOGICAL-c426t-195999c7b586cb908086c4c046a2da7fe3288b5fdf0da5b4c3973bd0ab69064c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347683806453$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6827403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Spencer-Green, George</creatorcontrib><creatorcontrib>Schlesinger, Margaret</creatorcontrib><creatorcontrib>Bove, Kevin E.</creatorcontrib><creatorcontrib>Levinson, Joseph E.</creatorcontrib><creatorcontrib>Schaller, Jane G.</creatorcontrib><creatorcontrib>Hanson, Virgil</creatorcontrib><creatorcontrib>Crowe, William E.</creatorcontrib><title>Nailfold capillary abnormalities in childhood rheumatic diseases</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>The nailfold capillary patterns of 84 patients with a variety of childhood rheumatic diseases and 34 normal control subjects were observed. Distinctive morphologic abnormalities with capillary dilation and dropout of surrounding structures were noted in two groups: patients with childhood dermatomyositis and with scleroderma (
P<0.001). Among those with scleroderma, capillary abnormalities were found in all nine patients with systemic disease and in none of 10 patients with cutaneous disease only (Fisher's exact
P<0.001). Of 25 patients with dermatomyositis for whom muscle biopsies were available for analysis, abnormal nailfold capillary pattern was found with highest prevalence in patients with two or more specific vascular lesions noted on biopsy (Fisher's exact
P=0.041). Nailfold capillary abnormalities are present in distinct populations of childhood rheumatic diseases, reflect the underlying vasculopathy of childhood dermatomyositis, and may be of diagnostic value in distinguishing localized from systemic scleroderma.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Arthritis, Juvenile - pathology</subject><subject>Capillaries - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Collagen Diseases - pathology</subject><subject>Dermatomyositis - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Nails</subject><subject>Scleroderma, Localized - pathology</subject><subject>Scleroderma, Systemic - pathology</subject><subject>Skin - blood supply</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPwzAQhC0EKqXwEyrlhOAQ2MSOY58AVbykCg7A2fIrqlESFztB4t_jPsSV0xx2dmfnQ2hewFUBBb1-AyjLHJOaXjB8yYCSKscHaFoAr3PKMD5E0z_LMTqJ8RMAOAGYoAllZU0AT9Hti3Rt41uTabl2bSvDTyZV70MnWzc4GzPXZ3rlWrPy3mRhZcdODk5nxkUro42n6KiRbbRne52hj4f798VTvnx9fF7cLXNNSjrkBa8457pWFaNacWCQlGggVJZG1o3FJWOqakwDRlaKaMxrrAxIRXmqpvEMne_uroP_Gm0cROeitunj3voxCgaYFRSqZKx2Rh18jME2Yh1cl3qJAsSGnNiSExssgmGxJSdw2pvvA0bVWfO3tUeV5je7uU0tv50NImpne22NC1YPwnj3T8Iv5LV9pg</recordid><startdate>198303</startdate><enddate>198303</enddate><creator>Spencer-Green, George</creator><creator>Schlesinger, Margaret</creator><creator>Bove, Kevin E.</creator><creator>Levinson, Joseph E.</creator><creator>Schaller, Jane G.</creator><creator>Hanson, Virgil</creator><creator>Crowe, William E.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198303</creationdate><title>Nailfold capillary abnormalities in childhood rheumatic diseases</title><author>Spencer-Green, George ; Schlesinger, Margaret ; Bove, Kevin E. ; Levinson, Joseph E. ; Schaller, Jane G. ; Hanson, Virgil ; Crowe, William E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-195999c7b586cb908086c4c046a2da7fe3288b5fdf0da5b4c3973bd0ab69064c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Arthritis, Juvenile - pathology</topic><topic>Capillaries - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Collagen Diseases - pathology</topic><topic>Dermatomyositis - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Nails</topic><topic>Scleroderma, Localized - pathology</topic><topic>Scleroderma, Systemic - pathology</topic><topic>Skin - blood supply</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Spencer-Green, George</creatorcontrib><creatorcontrib>Schlesinger, Margaret</creatorcontrib><creatorcontrib>Bove, Kevin E.</creatorcontrib><creatorcontrib>Levinson, Joseph E.</creatorcontrib><creatorcontrib>Schaller, Jane G.</creatorcontrib><creatorcontrib>Hanson, Virgil</creatorcontrib><creatorcontrib>Crowe, William E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Spencer-Green, George</au><au>Schlesinger, Margaret</au><au>Bove, Kevin E.</au><au>Levinson, Joseph E.</au><au>Schaller, Jane G.</au><au>Hanson, Virgil</au><au>Crowe, William E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nailfold capillary abnormalities in childhood rheumatic diseases</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1983-03</date><risdate>1983</risdate><volume>102</volume><issue>3</issue><spage>341</spage><epage>346</epage><pages>341-346</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>The nailfold capillary patterns of 84 patients with a variety of childhood rheumatic diseases and 34 normal control subjects were observed. Distinctive morphologic abnormalities with capillary dilation and dropout of surrounding structures were noted in two groups: patients with childhood dermatomyositis and with scleroderma (
P<0.001). Among those with scleroderma, capillary abnormalities were found in all nine patients with systemic disease and in none of 10 patients with cutaneous disease only (Fisher's exact
P<0.001). Of 25 patients with dermatomyositis for whom muscle biopsies were available for analysis, abnormal nailfold capillary pattern was found with highest prevalence in patients with two or more specific vascular lesions noted on biopsy (Fisher's exact
P=0.041). Nailfold capillary abnormalities are present in distinct populations of childhood rheumatic diseases, reflect the underlying vasculopathy of childhood dermatomyositis, and may be of diagnostic value in distinguishing localized from systemic scleroderma.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>6827403</pmid><doi>10.1016/S0022-3476(83)80645-3</doi><tpages>6</tpages></addata></record> |
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| ispartof | The Journal of pediatrics, 1983-03, Vol.102 (3), p.341-346 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Arthritis, Juvenile - pathology Capillaries - pathology Child Child, Preschool Collagen Diseases - pathology Dermatomyositis - pathology Female Humans Male Nails Scleroderma, Localized - pathology Scleroderma, Systemic - pathology Skin - blood supply |
| title | Nailfold capillary abnormalities in childhood rheumatic diseases |
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