DNA binding studies of 7-bulky substituted actinomycin analogs

The DNA binding properties of several 7-substituted aralkylaminoactinomycin D analogues have been studied by spectrophotometry, DNA melting temperature studies, DNA-drug dissociation studies, and circular dichroism. Despite the presence of such bulky groups as 2-pyrrolylmethylamino or 3,4-dichlorobe...

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Veröffentlicht in:	Journal of medicinal chemistry 1983-03, Vol.26 (3), p.448-451
Hauptverfasser:	Brennan, Thomas F, Sengupta, Sisir K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Circular Dichroism Dactinomycin - analogs & derivatives Dactinomycin - metabolism DNA - metabolism Hot Temperature Nucleic Acid Denaturation
Online-Zugang:	Volltext
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