Prostaglandin isosteres. 2. Chain-modified thiazolidinone prostaglandin analogs as renal vasodilators

Chain modification of a thiazolidinone prostaglandin isostere has led to the production of 4-[3-[3-[2-(1-hydroxycyclohexyl)ethyl]-4-oxo-2-thiazolidinyl]propyl] benzoic acid (5b) which at 1 mg/kg po in the conscious dog causes a 70% increase in renal blood flow over control values with a duration of...

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Veröffentlicht in:	Journal of medicinal chemistry 1983-03, Vol.26 (3), p.342-348
Hauptverfasser:	Bicking, John B, Bock, Mark G, Cragoe, Edward J, DiPardo, Robert M, Gould, Norman, Holtz, Wilbur J, Lee, T. J, Robb, Charles M, Smith, Robert L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Dogs Female Kidney - blood supply Models, Molecular Regional Blood Flow - drug effects Stereoisomerism Thiazoles - pharmacology Thiazolidines Vascular Resistance - drug effects Vasodilation - drug effects X-Ray Diffraction
Online-Zugang:	Volltext
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