Construction and evaluation of live attenuated vaccine strains of Shigella flexneri and Shigella dysenteriae 1

Shigellosis is an invasive disease of the human colon which is particularly prevalent among children of the developing world. No proper vaccine is available to protect against this enteric disease. It is currently accepted that only live strains with attenuated virulence administered orally may elic...

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Veröffentlicht in:	Research in microbiology 1990-09, Vol.141 (7-8), p.907-912
Hauptverfasser:	Fontaine, A., Arondel, J., Sansonetti, P.J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Vaccines - genetics Bacterial Vaccines - isolation & purification Bacteriology Biological and medical sciences Fundamental and applied biological sciences. Psychology Humans Macaca Microbiology Mutation Shigella dysenteriae - genetics Shigella dysenteriae - immunology Shigella flexneri - genetics Shigella flexneri - immunology Shigella, Vaccine, Shigellosis Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Attenuated - genetics Vaccines, Attenuated - isolation & purification Vaccines, Synthetic - genetics Vaccines, Synthetic - isolation & purification Virulence - genetics Virulence, Mutations
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