Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat

Dose-response relationships between aspirin-induced cyclo-oxygenase inhibition and gastric mucosal injury were studied in rats. Oral or parenteral aspirin, 25 mg/kg, inhibited prostaglandin generation by 87%–95% at 1, 3, and 6 h with no lesion formation. Aspirin, 100 mg/kg, inhibited prostaglandin g...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1983-04, Vol.84 (4), p.756-761
Hauptverfasser:	Ligumsky, Moshe, Golanska, Elizabeth M., Hansen, Duane G., Kauffman, Gordon L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Aspirin - administration & dosage Aspirin - pharmacology Biological and medical sciences Cyclooxygenase Inhibitors Digestive system Dose-Response Relationship, Drug Epoprostenol - biosynthesis Gastric Mucosa - drug effects Gastric Mucosa - enzymology Injections, Intraperitoneal Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Taurocholic Acid - pharmacology
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