Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat
Dose-response relationships between aspirin-induced cyclo-oxygenase inhibition and gastric mucosal injury were studied in rats. Oral or parenteral aspirin, 25 mg/kg, inhibited prostaglandin generation by 87%–95% at 1, 3, and 6 h with no lesion formation. Aspirin, 100 mg/kg, inhibited prostaglandin g...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1983-04, Vol.84 (4), p.756-761 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
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| creator | Ligumsky, Moshe Golanska, Elizabeth M. Hansen, Duane G. Kauffman, Gordon L. |
| description | Dose-response relationships between aspirin-induced cyclo-oxygenase inhibition and gastric mucosal injury were studied in rats. Oral or parenteral aspirin, 25 mg/kg, inhibited prostaglandin generation by 87%–95% at 1, 3, and 6 h with no lesion formation. Aspirin, 100 mg/kg, inhibited prostaglandin generation by 95%–98% at 1, 3, and 6 h, but lesions were observed only when aspirin was given orally. Three-hour pretreatment with intraperitoneal aspirin, 12.5 mg/kg, did not enhance the mucosal injury caused by 10 mM acidified taurocholate, although prostaglandin generation was inhibited by 80%. Pretreatment with 25 mg/kg aspirin inhibited prostaglandin generation by 89% and was associated with significant mucosal injury by acidified taurocholate. We conclude that aspirin-induced 95% inhibition of gastric mucosal cyclo-oxygenase is not, by itself, sufficient to produce lesions and inhibition by >80% is required to predispose the gastric mucosa to injury by otherwise mild irritants. |
| doi_str_mv | 10.1016/0016-5085(83)90143-9 |
| format | Article |
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Oral or parenteral aspirin, 25 mg/kg, inhibited prostaglandin generation by 87%–95% at 1, 3, and 6 h with no lesion formation. Aspirin, 100 mg/kg, inhibited prostaglandin generation by 95%–98% at 1, 3, and 6 h, but lesions were observed only when aspirin was given orally. Three-hour pretreatment with intraperitoneal aspirin, 12.5 mg/kg, did not enhance the mucosal injury caused by 10 mM acidified taurocholate, although prostaglandin generation was inhibited by 80%. Pretreatment with 25 mg/kg aspirin inhibited prostaglandin generation by 89% and was associated with significant mucosal injury by acidified taurocholate. We conclude that aspirin-induced 95% inhibition of gastric mucosal cyclo-oxygenase is not, by itself, sufficient to produce lesions and inhibition by >80% is required to predispose the gastric mucosa to injury by otherwise mild irritants.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1016/0016-5085(83)90143-9</identifier><identifier>PMID: 6402412</identifier><identifier>CODEN: GASTAB</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Administration, Oral ; Animals ; Aspirin - administration & dosage ; Aspirin - pharmacology ; Biological and medical sciences ; Cyclooxygenase Inhibitors ; Digestive system ; Dose-Response Relationship, Drug ; Epoprostenol - biosynthesis ; Gastric Mucosa - drug effects ; Gastric Mucosa - enzymology ; Injections, Intraperitoneal ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Taurocholic Acid - pharmacology</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 1983-04, Vol.84 (4), p.756-761</ispartof><rights>1983</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-80de55d1d3f12e3433a6395b6210821f7a264c570c0a0a5484370fb7d79d341f3</citedby><cites>FETCH-LOGICAL-c498t-80de55d1d3f12e3433a6395b6210821f7a264c570c0a0a5484370fb7d79d341f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0016508583901439$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65308</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9217218$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6402412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ligumsky, Moshe</creatorcontrib><creatorcontrib>Golanska, Elizabeth M.</creatorcontrib><creatorcontrib>Hansen, Duane G.</creatorcontrib><creatorcontrib>Kauffman, Gordon L.</creatorcontrib><title>Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat</title><title>Gastroenterology (New York, N.Y. 1943)</title><addtitle>Gastroenterology</addtitle><description>Dose-response relationships between aspirin-induced cyclo-oxygenase inhibition and gastric mucosal injury were studied in rats. Oral or parenteral aspirin, 25 mg/kg, inhibited prostaglandin generation by 87%–95% at 1, 3, and 6 h with no lesion formation. Aspirin, 100 mg/kg, inhibited prostaglandin generation by 95%–98% at 1, 3, and 6 h, but lesions were observed only when aspirin was given orally. Three-hour pretreatment with intraperitoneal aspirin, 12.5 mg/kg, did not enhance the mucosal injury caused by 10 mM acidified taurocholate, although prostaglandin generation was inhibited by 80%. Pretreatment with 25 mg/kg aspirin inhibited prostaglandin generation by 89% and was associated with significant mucosal injury by acidified taurocholate. We conclude that aspirin-induced 95% inhibition of gastric mucosal cyclo-oxygenase is not, by itself, sufficient to produce lesions and inhibition by >80% is required to predispose the gastric mucosa to injury by otherwise mild irritants.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Aspirin - administration & dosage</subject><subject>Aspirin - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cyclooxygenase Inhibitors</subject><subject>Digestive system</subject><subject>Dose-Response Relationship, Drug</subject><subject>Epoprostenol - biosynthesis</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - enzymology</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Taurocholic Acid - pharmacology</subject><issn>0016-5085</issn><issn>1528-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQhkVoSJ00_yCBPZSSHjYdfa20l0AwaRMIBEp7FrJW6yisJVez28b_vnJsfMxl5vA-7zA8hFxQuKZAm29QRi1ByyvNv7ZABa_bIzKjkum6ZOwDmR2Qj-QU8QUAWq7pCTlpBDBB2Yz8vMV1yCFWzsYqxOewCGO1tDjm4KrV5BLaoXIbN6Q6vW6WPlr01b8wPqdpLJ0JQ1xWg8eQIpZ-le34iRz3dkB_vt9n5Pf3u1_z-_rx6cfD_PaxdqLVY62h81J2tOM9ZZ4Lzm3DW7loGAXNaK8sa4STChxYsFJowRX0C9WptuOC9vyMfNndXef0Z_I4mlVA54fBRp8mNBq4EkqqAood6HJCzL436xxWNm8MBbNVabaezNaT0dy8qTRtqV3u70-Lle8Opb27kn_e5xadHfpsowt4wFpGFaO6YDc7zBcXf4PPBl3w0fkuZO9G06Xw_h__Afrdjro</recordid><startdate>198304</startdate><enddate>198304</enddate><creator>Ligumsky, Moshe</creator><creator>Golanska, Elizabeth M.</creator><creator>Hansen, Duane G.</creator><creator>Kauffman, Gordon L.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198304</creationdate><title>Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat</title><author>Ligumsky, Moshe ; Golanska, Elizabeth M. ; Hansen, Duane G. ; Kauffman, Gordon L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-80de55d1d3f12e3433a6395b6210821f7a264c570c0a0a5484370fb7d79d341f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Aspirin - administration & dosage</topic><topic>Aspirin - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cyclooxygenase Inhibitors</topic><topic>Digestive system</topic><topic>Dose-Response Relationship, Drug</topic><topic>Epoprostenol - biosynthesis</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - enzymology</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Taurocholic Acid - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ligumsky, Moshe</creatorcontrib><creatorcontrib>Golanska, Elizabeth M.</creatorcontrib><creatorcontrib>Hansen, Duane G.</creatorcontrib><creatorcontrib>Kauffman, Gordon L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ligumsky, Moshe</au><au>Golanska, Elizabeth M.</au><au>Hansen, Duane G.</au><au>Kauffman, Gordon L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat</atitle><jtitle>Gastroenterology (New York, N.Y. 1943)</jtitle><addtitle>Gastroenterology</addtitle><date>1983-04</date><risdate>1983</risdate><volume>84</volume><issue>4</issue><spage>756</spage><epage>761</epage><pages>756-761</pages><issn>0016-5085</issn><eissn>1528-0012</eissn><coden>GASTAB</coden><abstract>Dose-response relationships between aspirin-induced cyclo-oxygenase inhibition and gastric mucosal injury were studied in rats. Oral or parenteral aspirin, 25 mg/kg, inhibited prostaglandin generation by 87%–95% at 1, 3, and 6 h with no lesion formation. Aspirin, 100 mg/kg, inhibited prostaglandin generation by 95%–98% at 1, 3, and 6 h, but lesions were observed only when aspirin was given orally. Three-hour pretreatment with intraperitoneal aspirin, 12.5 mg/kg, did not enhance the mucosal injury caused by 10 mM acidified taurocholate, although prostaglandin generation was inhibited by 80%. Pretreatment with 25 mg/kg aspirin inhibited prostaglandin generation by 89% and was associated with significant mucosal injury by acidified taurocholate. We conclude that aspirin-induced 95% inhibition of gastric mucosal cyclo-oxygenase is not, by itself, sufficient to produce lesions and inhibition by >80% is required to predispose the gastric mucosa to injury by otherwise mild irritants.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6402412</pmid><doi>10.1016/0016-5085(83)90143-9</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Gastroenterology (New York, N.Y. 1943), 1983-04, Vol.84 (4), p.756-761 |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Alma/SFX Local Collection |
| subjects | Administration, Oral Animals Aspirin - administration & dosage Aspirin - pharmacology Biological and medical sciences Cyclooxygenase Inhibitors Digestive system Dose-Response Relationship, Drug Epoprostenol - biosynthesis Gastric Mucosa - drug effects Gastric Mucosa - enzymology Injections, Intraperitoneal Male Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred Strains Taurocholic Acid - pharmacology |
| title | Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in rat |
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