Physico-chemical characterization of a new salt of ibuprofen

A new salt of ibuprofen was prepared by reaction with t-butylamine; its formation was confirmed by IR and 1H-NMR spectroscopy. The salt was characterized by thermoanalytical, X-ray powder diffraction and solubility studies. The salt was found to be 1.5 times more soluble in water than was ibuprofen,...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1990, Vol.8 (4), p.321-327
Hauptverfasser:	Suleiman, M.S., Najib, N.M., Hassan, M.A., Abdel-Hamid, M.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	1H-NMR spectroscopy Biological and medical sciences Butylamines - chemistry Calorimetry, Differential Scanning - methods Chromatography, Thin Layer Crystallization General pharmacology Ibuprofen - chemistry Ibuprofen-t-butylamine IR spectroscopy Magnetic Resonance Spectroscopy Medical sciences Microscopy - methods Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Solubility solubility studies Spectrophotometry, Infrared thermoanalysis X-Ray Diffraction X-ray powder diffraction
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Beschreibung
Zusammenfassung:	A new salt of ibuprofen was prepared by reaction with t-butylamine; its formation was confirmed by IR and 1H-NMR spectroscopy. The salt was characterized by thermoanalytical, X-ray powder diffraction and solubility studies. The salt was found to be 1.5 times more soluble in water than was ibuprofen, with an enthalpy of solution of −8.84 kcal mol −1.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/0731-7085(90)80045-Q