Multiple transforming growth factor-beta-inducible elements regulate expression of the plasminogen activator inhibitor type-1 gene in Hep G2 cells

Regulation of plasminogen activation by plasminogen activator inhibitor type-1 (PAI-1) is a critical feature of many biological processes. Transforming growth factor-beta (TGF-beta) induces PAI-1 mRNA and protein in several types of cultured cells, including Hep G2 cells. The present study was perfo...

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Veröffentlicht in:	The Journal of biological chemistry 1991-01, Vol.266 (2), p.1092-1100
Hauptverfasser:	Westerhausen, D R, Hopkins, W E, Billadello, J J
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Northern Cell physiology Chimera Chloramphenicol O-Acetyltransferase - genetics enhancers Fundamental and applied biological sciences. Psychology Gene Expression Regulation genes HepG2 cells Humans Molecular and cellular biology Plasminogen Inactivators Promoter Regions, Genetic promoters Protein Synthesis Inhibitors Responses to growth factors, tumor promotors, other factors RNA, Messenger - genetics Transcription, Genetic transforming growth factor- beta Transforming Growth Factors - metabolism Tumor Cells, Cultured
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