Affinity alkylation of bacterial delta 5-3-ketosteroid isomerase. Identification of the amino acid modified by steroidal 17 beta-oxiranes

The two steroidal 17 beta-oxiranes, spiro-17 beta-oxiranyl-delta 4-androsten-3-one (4 beta) and spiro-17 beta-oxiranylestra-1,3,5(10),6,8-pentaene-3-ol (5 beta) are active site-directed irreversible inhibitors of bacterial delta 5-3-ketosteroid isomerase. For each inhibitor, a stoichiometry of one m...

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Veröffentlicht in:	The Journal of biological chemistry 1983-01, Vol.258 (2), p.909-915
Hauptverfasser:	Kayser, R H, Bounds, P L, Bevins, C L, Pollack, R M
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - analysis Androstenes - pharmacology Binding Sites Chromatography, High Pressure Liquid Estrenes - pharmacology Isomerases - antagonists & inhibitors Peptide Fragments - analysis Steroid Isomerases - antagonists & inhibitors Time Factors Trypsin - metabolism
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