Cultured thyroid allografts induce a state of partial tolerance in adult recipient mice
Thyroid allografts (BALB/c) prepared for transplantation by cyclophosphamide pretreatment of the donor, followed by organ culture of donor tissues for 3 weeks in a gas phase of 95% O2-5% CO2 function in normal CBA recipient mice for greater than or equal to 350 days. Up to 100 days post-transplantat...
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| Veröffentlicht in: | Transplantation 1983-01, Vol.35 (1), p.62-67 |
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| container_title | Transplantation |
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| creator | Donohoe, J A Andrus, L Bowen, K M Simeonovic, C Prowse, S J Lafferty, K J |
| description | Thyroid allografts (BALB/c) prepared for transplantation by cyclophosphamide pretreatment of the donor, followed by organ culture of donor tissues for 3 weeks in a gas phase of 95% O2-5% CO2 function in normal CBA recipient mice for greater than or equal to 350 days. Up to 100 days post-transplantation, the tissue can be rejected by challenge of the recipient with 10(5) BALB/c peritoneal cells. After prolonged residence in the recipient (greater than 100, less than or equal to 350 days), only a proportion of allografts are rejected when the recipient is challenged with 10(5) followed by 10(6) peritoneal cells of donor origin. Recipients of long-term allografts are partially tolerant of BALB/c tissues. They are hyporesponsive to in vivo challenge with BALB/c spleen cells. However, lymph node cells from these animals respond essentially normally to stimulation with BALB/c spleen cells in vitro. Tolerant recipients will accept a second uncultured BALB/c allograft after a transitory rejection crisis. This crisis is not observed in the primary allograft. |
| doi_str_mv | 10.1097/00007890-198301000-00012 |
| format | Article |
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Up to 100 days post-transplantation, the tissue can be rejected by challenge of the recipient with 10(5) BALB/c peritoneal cells. After prolonged residence in the recipient (greater than 100, less than or equal to 350 days), only a proportion of allografts are rejected when the recipient is challenged with 10(5) followed by 10(6) peritoneal cells of donor origin. Recipients of long-term allografts are partially tolerant of BALB/c tissues. They are hyporesponsive to in vivo challenge with BALB/c spleen cells. However, lymph node cells from these animals respond essentially normally to stimulation with BALB/c spleen cells in vitro. Tolerant recipients will accept a second uncultured BALB/c allograft after a transitory rejection crisis. This crisis is not observed in the primary allograft.</description><identifier>ISSN: 0041-1337</identifier><identifier>DOI: 10.1097/00007890-198301000-00012</identifier><identifier>PMID: 6823693</identifier><language>eng</language><publisher>United States</publisher><subject>Aging ; Animals ; Female ; Graft Rejection ; Immune Tolerance ; Isoantigens - immunology ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred CBA ; Organ Culture Techniques ; Thyroid Gland - immunology ; Thyroid Gland - transplantation ; Transplantation, Homologous - methods</subject><ispartof>Transplantation, 1983-01, Vol.35 (1), p.62-67</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-96a356a4a9ba1e3b83bd781faebd05b32a752ada35f4e4886abbf68f05dfc63e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6823693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Donohoe, J A</creatorcontrib><creatorcontrib>Andrus, L</creatorcontrib><creatorcontrib>Bowen, K M</creatorcontrib><creatorcontrib>Simeonovic, C</creatorcontrib><creatorcontrib>Prowse, S J</creatorcontrib><creatorcontrib>Lafferty, K J</creatorcontrib><title>Cultured thyroid allografts induce a state of partial tolerance in adult recipient mice</title><title>Transplantation</title><addtitle>Transplantation</addtitle><description>Thyroid allografts (BALB/c) prepared for transplantation by cyclophosphamide pretreatment of the donor, followed by organ culture of donor tissues for 3 weeks in a gas phase of 95% O2-5% CO2 function in normal CBA recipient mice for greater than or equal to 350 days. Up to 100 days post-transplantation, the tissue can be rejected by challenge of the recipient with 10(5) BALB/c peritoneal cells. After prolonged residence in the recipient (greater than 100, less than or equal to 350 days), only a proportion of allografts are rejected when the recipient is challenged with 10(5) followed by 10(6) peritoneal cells of donor origin. Recipients of long-term allografts are partially tolerant of BALB/c tissues. They are hyporesponsive to in vivo challenge with BALB/c spleen cells. However, lymph node cells from these animals respond essentially normally to stimulation with BALB/c spleen cells in vitro. Tolerant recipients will accept a second uncultured BALB/c allograft after a transitory rejection crisis. This crisis is not observed in the primary allograft.</description><subject>Aging</subject><subject>Animals</subject><subject>Female</subject><subject>Graft Rejection</subject><subject>Immune Tolerance</subject><subject>Isoantigens - immunology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred CBA</subject><subject>Organ Culture Techniques</subject><subject>Thyroid Gland - immunology</subject><subject>Thyroid Gland - transplantation</subject><subject>Transplantation, Homologous - methods</subject><issn>0041-1337</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1PwzAMhnMAjTH4CUg5cSskTZumRzTxJU3iAuIYOY0DQf0YSXrYvyewMUuWZft9bekhhHJ2w1nb3LIcjWpZwVslGM9dkZOXJ2TJWMULLkRzRs5j_MrjWjTNgiykKoVsxZK8r-c-zQEtTZ-7MHlLoe-njwAuRepHO3dIgcYECenk6BZC8tDTNPUYYMxLP1Kw-QYN2PmtxzHRwXd4QU4d9BEvD3VF3h7uX9dPxebl8Xl9tyk6IVkqWgmillBBa4CjMEoY2yjuAI1ltRElNHUJNotchZVSEoxxUjlWW9dJgWJFrvd3t2H6njEmPfjYYd_DiNMctWJCNpWoslDthV2YYgzo9Db4AcJOc6Z_Oep_jvrIUf9xzNarw4_ZDGiPxgNE8QPzCHGN</recordid><startdate>198301</startdate><enddate>198301</enddate><creator>Donohoe, J A</creator><creator>Andrus, L</creator><creator>Bowen, K M</creator><creator>Simeonovic, C</creator><creator>Prowse, S J</creator><creator>Lafferty, K J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198301</creationdate><title>Cultured thyroid allografts induce a state of partial tolerance in adult recipient mice</title><author>Donohoe, J A ; Andrus, L ; Bowen, K M ; Simeonovic, C ; Prowse, S J ; Lafferty, K J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-96a356a4a9ba1e3b83bd781faebd05b32a752ada35f4e4886abbf68f05dfc63e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Female</topic><topic>Graft Rejection</topic><topic>Immune Tolerance</topic><topic>Isoantigens - immunology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred CBA</topic><topic>Organ Culture Techniques</topic><topic>Thyroid Gland - immunology</topic><topic>Thyroid Gland - transplantation</topic><topic>Transplantation, Homologous - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donohoe, J A</creatorcontrib><creatorcontrib>Andrus, L</creatorcontrib><creatorcontrib>Bowen, K M</creatorcontrib><creatorcontrib>Simeonovic, C</creatorcontrib><creatorcontrib>Prowse, S J</creatorcontrib><creatorcontrib>Lafferty, K J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donohoe, J A</au><au>Andrus, L</au><au>Bowen, K M</au><au>Simeonovic, C</au><au>Prowse, S J</au><au>Lafferty, K J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cultured thyroid allografts induce a state of partial tolerance in adult recipient mice</atitle><jtitle>Transplantation</jtitle><addtitle>Transplantation</addtitle><date>1983-01</date><risdate>1983</risdate><volume>35</volume><issue>1</issue><spage>62</spage><epage>67</epage><pages>62-67</pages><issn>0041-1337</issn><abstract>Thyroid allografts (BALB/c) prepared for transplantation by cyclophosphamide pretreatment of the donor, followed by organ culture of donor tissues for 3 weeks in a gas phase of 95% O2-5% CO2 function in normal CBA recipient mice for greater than or equal to 350 days. Up to 100 days post-transplantation, the tissue can be rejected by challenge of the recipient with 10(5) BALB/c peritoneal cells. After prolonged residence in the recipient (greater than 100, less than or equal to 350 days), only a proportion of allografts are rejected when the recipient is challenged with 10(5) followed by 10(6) peritoneal cells of donor origin. Recipients of long-term allografts are partially tolerant of BALB/c tissues. They are hyporesponsive to in vivo challenge with BALB/c spleen cells. However, lymph node cells from these animals respond essentially normally to stimulation with BALB/c spleen cells in vitro. Tolerant recipients will accept a second uncultured BALB/c allograft after a transitory rejection crisis. This crisis is not observed in the primary allograft.</abstract><cop>United States</cop><pmid>6823693</pmid><doi>10.1097/00007890-198301000-00012</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1337 |
| ispartof | Transplantation, 1983-01, Vol.35 (1), p.62-67 |
| issn | 0041-1337 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80367434 |
| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aging Animals Female Graft Rejection Immune Tolerance Isoantigens - immunology Male Mice Mice, Inbred BALB C Mice, Inbred CBA Organ Culture Techniques Thyroid Gland - immunology Thyroid Gland - transplantation Transplantation, Homologous - methods |
| title | Cultured thyroid allografts induce a state of partial tolerance in adult recipient mice |
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