Membrane-Binding Domain of the Small G Protein G25K Contains an S-(all- Trans-Geranylgeranyl)Cysteine Methyl Ester at its Carboxyl Terminus

We showed previously that a 23-kDa guanine nucleotide-binding protein (G protein) purified from bovine brain membranes is carboxyl methylated and that this modification occurs at or near the membrane-binding domain. In the present study, we identified this small G protein as G25K (formerly termed Gp...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1991-01, Vol.88 (1), p.286-290
Hauptverfasser:	Yamane, Harvey K., Farnsworth, Christopher C., Xie, Hongying, Evans, Tony, Howald, William N., Gelb, Michael H., Glomset, John A., Clarke, Steven, Bernard K.-K. Fung
Format:	Artikel
Sprache:	eng
Schlagworte:	550201 - Biochemistry- Tracer Techniques AMINES Amino Acid Sequence Amino acids Analytical, structural and metabolic biochemistry ANIMALS Antibodies AROMATICS AZAARENES BASIC BIOLOGICAL SCIENCES Binding and carrier proteins BIOCHEMISTRY Biological and medical sciences Brain - metabolism CATTLE Cell Membrane - metabolism CHEMICAL REACTIONS CHEMISTRY CHROMATOGRAPHY Cysteine - analogs & derivatives Cysteine - analysis cysteine methyl esters Diterpenes - analysis DOMESTIC ANIMALS ESTERIFICATION ESTERS Fundamental and applied biological sciences. Psychology GAS CHROMATOGRAPHY Gas Chromatography-Mass Spectrometry GTP-Binding Proteins - isolation & purification GTP-Binding Proteins - metabolism GUANINE guanine nucleotide-binding protein HETEROCYCLIC COMPOUNDS HYDROGEN COMPOUNDS HYDROXY COMPOUNDS MAMMALS MASS SPECTROSCOPY MEMBRANE PROTEINS Methylation Molecular Sequence Data MOLECULAR STRUCTURE Molecular Weight Oligopeptides - chemical synthesis ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS Peptide Fragments - isolation & purification Placenta Platelets PROTEINS PURINES RUMINANTS SEPARATION PROCESSES SPECTROSCOPY Terpenoids TRITIUM COMPOUNDS Ungulates VERTEBRATES
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