$Isoproterenol Antagonizes Prolongation of Refractory Period by the Class III Antiarrhythmic Agent E-4031 in Guinea Pig Myocytes Mechanism of Action$

Isoproterenol Antagonizes Prolongation of Refractory Period by the Class III Antiarrhythmic Agent E-4031 in Guinea Pig Myocytes Mechanism of Action

The mechanism by which isoproterenol (ISO) prevents the prolongation of action potential duration (APD) and refractory period (RP) by the class III antiarrhythmic agent E-4031 was studied. E-4031 (1 μM) increased RP by 501% with no effect on contractile force in papillary muscles isolated from guine...

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Veröffentlicht in:	Circulation research 1991-01, Vol.68 (1), p.77-84
Hauptverfasser:	Sanguinetti, Michael C, Jurkiewicz, Nancy K, Scott, Ann, Siegl, Peter K.S
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Animals Anti-Arrhythmia Agents - pharmacology Cell Separation Electric Conductivity Guinea Pigs Heart - drug effects Heart - physiology In Vitro Techniques Isoproterenol - pharmacology Myocardium - cytology Papillary Muscles - drug effects Piperidines - antagonists & inhibitors Piperidines - pharmacology Pyridines - antagonists & inhibitors Pyridines - pharmacology Refractory Period, Electrophysiological - drug effects
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