Effective Doses of Epidural Morphine for Relief of Postcholecystectomy Pain
Having previously established the effective dose of intrathecal morphine for relief of postcholecystectomy pain, we determined in this study the effective dose of epidural morphine for relief of postcholecystectomy pain in 154 patients given epidural injections of a placebo (group 1, n = 49), 2 mg m...
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| Veröffentlicht in: | Anesthesia and analgesia 1991-01, Vol.72 (1), p.80-83 |
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| creator | Yamaguchi, Hiroshi Watanabe, Seiji Harukuni, Izumi Hamaya, Yoshihiro |
| description | Having previously established the effective dose of intrathecal morphine for relief of postcholecystectomy pain, we determined in this study the effective dose of epidural morphine for relief of postcholecystectomy pain in 154 patients given epidural injections of a placebo (group 1, n = 49), 2 mg morphine (group 2, n = 54), or 4 mg morphine (group 3, n = 51) intraoperatively mixed in 1.5% lidocaine. The percentage of patients who did not request an analgesic, 30 mg IM pentazocine, for relief of pain during the first 24 postoperative hours was significantly greater in groups 2 and 3 than in group 1. In patients who did need 30 mg IM pentazocine postoperatively, the number of times pentazocine was administered was also significantly greater in group 1 than in groups 2 and 3. The percentage of patients developing respiratory depression OY vomiting in the first 48 postoperative hours was similar in the three groups. Based on the present data and those we previously reported for intrathecal morphine, we conclude that an epidural morphine dose of 2–4 mg and an intrathecal morphine dose of 0.06–0.12 mg are equipotent for relief of postcholecystectomy pain. |
| doi_str_mv | 10.1213/00000539-199101000-00014 |
| format | Article |
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The percentage of patients who did not request an analgesic, 30 mg IM pentazocine, for relief of pain during the first 24 postoperative hours was significantly greater in groups 2 and 3 than in group 1. In patients who did need 30 mg IM pentazocine postoperatively, the number of times pentazocine was administered was also significantly greater in group 1 than in groups 2 and 3. The percentage of patients developing respiratory depression OY vomiting in the first 48 postoperative hours was similar in the three groups. Based on the present data and those we previously reported for intrathecal morphine, we conclude that an epidural morphine dose of 2–4 mg and an intrathecal morphine dose of 0.06–0.12 mg are equipotent for relief of postcholecystectomy pain.</description><identifier>ISSN: 0003-2999</identifier><identifier>EISSN: 1526-7598</identifier><identifier>DOI: 10.1213/00000539-199101000-00014</identifier><identifier>PMID: 1984381</identifier><identifier>CODEN: AACRAT</identifier><language>eng</language><publisher>Hagerstown, MD: International Anesthesia Research Society</publisher><subject>Adult ; Aged ; Analgesia, Epidural ; Analgesics ; Biological and medical sciences ; Cholecystectomy ; Female ; Humans ; Injections, Epidural ; Injections, Spinal ; Male ; Medical sciences ; Middle Aged ; Morphine - administration & dosage ; Neuropharmacology ; Pain, Postoperative - drug therapy ; Pharmacology. Drug treatments</subject><ispartof>Anesthesia and analgesia, 1991-01, Vol.72 (1), p.80-83</ispartof><rights>1991 International Anesthesia Research Society</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4354-287740227f84c63590e43acb73e2930d060ac0944cc7f8fc84e1b9ca1940abfb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf><![CDATA[$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&PDF=y&D=ovft&AN=00000539-199101000-00014$$EPDF$$P50$$Gwolterskluwer$$H]]></linktopdf><linktohtml>$$Uhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&NEWS=n&CSC=Y&PAGE=fulltext&D=ovft&AN=00000539-199101000-00014$$EHTML$$P50$$Gwolterskluwer$$H</linktohtml><link.rule.ids>315,781,785,4025,4610,27928,27929,27930,64671,65466</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19705483$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1984381$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamaguchi, Hiroshi</creatorcontrib><creatorcontrib>Watanabe, Seiji</creatorcontrib><creatorcontrib>Harukuni, Izumi</creatorcontrib><creatorcontrib>Hamaya, Yoshihiro</creatorcontrib><title>Effective Doses of Epidural Morphine for Relief of Postcholecystectomy Pain</title><title>Anesthesia and analgesia</title><addtitle>Anesth Analg</addtitle><description>Having previously established the effective dose of intrathecal morphine for relief of postcholecystectomy pain, we determined in this study the effective dose of epidural morphine for relief of postcholecystectomy pain in 154 patients given epidural injections of a placebo (group 1, n = 49), 2 mg morphine (group 2, n = 54), or 4 mg morphine (group 3, n = 51) intraoperatively mixed in 1.5% lidocaine. The percentage of patients who did not request an analgesic, 30 mg IM pentazocine, for relief of pain during the first 24 postoperative hours was significantly greater in groups 2 and 3 than in group 1. In patients who did need 30 mg IM pentazocine postoperatively, the number of times pentazocine was administered was also significantly greater in group 1 than in groups 2 and 3. The percentage of patients developing respiratory depression OY vomiting in the first 48 postoperative hours was similar in the three groups. Based on the present data and those we previously reported for intrathecal morphine, we conclude that an epidural morphine dose of 2–4 mg and an intrathecal morphine dose of 0.06–0.12 mg are equipotent for relief of postcholecystectomy pain.</description><subject>Adult</subject><subject>Aged</subject><subject>Analgesia, Epidural</subject><subject>Analgesics</subject><subject>Biological and medical sciences</subject><subject>Cholecystectomy</subject><subject>Female</subject><subject>Humans</subject><subject>Injections, Epidural</subject><subject>Injections, Spinal</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Morphine - administration & dosage</subject><subject>Neuropharmacology</subject><subject>Pain, Postoperative - drug therapy</subject><subject>Pharmacology. Drug treatments</subject><issn>0003-2999</issn><issn>1526-7598</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVtPwyAYhonRzDn9CSa90bsqFNrCpdF5iDMuRq8JZR9plY4Jrcv-vczNw40khMD7vJA8IJQQfEYyQs_xeuRUpEQIgkncpHEStoOGJM-KtMwF30XDeEbTTAixjw5CeF0jmBcDNCCCM8rJEN2PjQHdNR-QXLkAIXEmGS-aWe-VTR6cX9TNHBLjfPIEtgGzzqcudLp2FvQqdLHs2lUyVc38EO0ZZQMcbdcRerkeP1_eppPHm7vLi0mqGc1ZmvGyZDjLSsOZLmguMDCqdFVSyATFM1xgpbFgTOuIGM0ZkEpoRQTDqjIVHaHTzb0L7957CJ1sm6DBWjUH1wfJMS0oK8sI8g2ovQvBg5EL37TKryTBcu1RfnuUPx7ll8dYPd6-0VctzH6LG3ExP9nmKmhljVdz3YQ_WIlzxmnk2IZbOtuBD2-2X4KXNSjb1fK_b6SfBpeJOA</recordid><startdate>199101</startdate><enddate>199101</enddate><creator>Yamaguchi, Hiroshi</creator><creator>Watanabe, Seiji</creator><creator>Harukuni, Izumi</creator><creator>Hamaya, Yoshihiro</creator><general>International Anesthesia Research Society</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199101</creationdate><title>Effective Doses of Epidural Morphine for Relief of Postcholecystectomy Pain</title><author>Yamaguchi, Hiroshi ; Watanabe, Seiji ; Harukuni, Izumi ; Hamaya, Yoshihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4354-287740227f84c63590e43acb73e2930d060ac0944cc7f8fc84e1b9ca1940abfb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analgesia, Epidural</topic><topic>Analgesics</topic><topic>Biological and medical sciences</topic><topic>Cholecystectomy</topic><topic>Female</topic><topic>Humans</topic><topic>Injections, Epidural</topic><topic>Injections, Spinal</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Morphine - administration & dosage</topic><topic>Neuropharmacology</topic><topic>Pain, Postoperative - drug therapy</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamaguchi, Hiroshi</creatorcontrib><creatorcontrib>Watanabe, Seiji</creatorcontrib><creatorcontrib>Harukuni, Izumi</creatorcontrib><creatorcontrib>Hamaya, Yoshihiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesia and analgesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaguchi, Hiroshi</au><au>Watanabe, Seiji</au><au>Harukuni, Izumi</au><au>Hamaya, Yoshihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effective Doses of Epidural Morphine for Relief of Postcholecystectomy Pain</atitle><jtitle>Anesthesia and analgesia</jtitle><addtitle>Anesth Analg</addtitle><date>1991-01</date><risdate>1991</risdate><volume>72</volume><issue>1</issue><spage>80</spage><epage>83</epage><pages>80-83</pages><issn>0003-2999</issn><eissn>1526-7598</eissn><coden>AACRAT</coden><abstract>Having previously established the effective dose of intrathecal morphine for relief of postcholecystectomy pain, we determined in this study the effective dose of epidural morphine for relief of postcholecystectomy pain in 154 patients given epidural injections of a placebo (group 1, n = 49), 2 mg morphine (group 2, n = 54), or 4 mg morphine (group 3, n = 51) intraoperatively mixed in 1.5% lidocaine. The percentage of patients who did not request an analgesic, 30 mg IM pentazocine, for relief of pain during the first 24 postoperative hours was significantly greater in groups 2 and 3 than in group 1. In patients who did need 30 mg IM pentazocine postoperatively, the number of times pentazocine was administered was also significantly greater in group 1 than in groups 2 and 3. The percentage of patients developing respiratory depression OY vomiting in the first 48 postoperative hours was similar in the three groups. Based on the present data and those we previously reported for intrathecal morphine, we conclude that an epidural morphine dose of 2–4 mg and an intrathecal morphine dose of 0.06–0.12 mg are equipotent for relief of postcholecystectomy pain.</abstract><cop>Hagerstown, MD</cop><pub>International Anesthesia Research Society</pub><pmid>1984381</pmid><doi>10.1213/00000539-199101000-00014</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Anesthesia and analgesia, 1991-01, Vol.72 (1), p.80-83 |
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| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB Electronic Journals Library |
| subjects | Adult Aged Analgesia, Epidural Analgesics Biological and medical sciences Cholecystectomy Female Humans Injections, Epidural Injections, Spinal Male Medical sciences Middle Aged Morphine - administration & dosage Neuropharmacology Pain, Postoperative - drug therapy Pharmacology. Drug treatments |
| title | Effective Doses of Epidural Morphine for Relief of Postcholecystectomy Pain |
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