Drug-resistant tuberculosis after gastrectomy. Double jeopardy?

Although an increased incidence of Mycobacterium tuberculosis infection is found in patients after subtotal gastrectomy, to my knowledge, the potential for gastrectomy to alter the course and outcome of typical mycobacterial disease has not been noted. I report the case of a patient who developed tu...

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Veröffentlicht in:Chest 1991-01, Vol.99 (1), p.245-247
1. Verfasser: WELSH, C. H
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description Although an increased incidence of Mycobacterium tuberculosis infection is found in patients after subtotal gastrectomy, to my knowledge, the potential for gastrectomy to alter the course and outcome of typical mycobacterial disease has not been noted. I report the case of a patient who developed tuberculosis after a Billroth II subtotal gastrectomy, malabsorbed his antibiotics, and subsequently manifested infection with a drug-resistant strain of M tuberculosis. Altered drug pharmacokinetics should be considered as an important metabolic consequence of subtotal gastrectomy.
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subjects Aged
Antibiotics, Antitubercular - pharmacokinetics
Antibiotics, Antitubercular - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antitubercular Agents - therapeutic use
Biological and medical sciences
Drug Resistance, Microbial
Drug Therapy, Combination
Gastrectomy - adverse effects
Humans
Intestinal Absorption
Male
Medical sciences
Mycobacterium tuberculosis
Mycobacterium tuberculosis - drug effects
Pharmacology. Drug treatments
Time Factors
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - etiology
title Drug-resistant tuberculosis after gastrectomy. Double jeopardy?
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