Platelet Glutathione Peroxidase Activity as an Index of Selenium Status in Rats
Glutathione peroxidase activity in platelets increased stepwise in selenium-depleted rats that were repleted with graded levels of dietary sodium selenite. In a 3-phase depletion/repletion/depletion feeding study, glutathione peroxidase activity was similar in platelets and liver, which apparently c...
Gespeichert in:
| Veröffentlicht in: | The Journal of nutrition 1983-01, Vol.113 (1), p.55-63 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 63 |
|---|---|
| container_issue | 1 |
| container_start_page | 55 |
| container_title | The Journal of nutrition |
| container_volume | 113 |
| creator | Levander, Orville A. DeLoach, Donna P. Morris, Virginia C. Moser, Phylis B. |
| description | Glutathione peroxidase activity in platelets increased stepwise in selenium-depleted rats that were repleted with graded levels of dietary sodium selenite. In a 3-phase depletion/repletion/depletion feeding study, glutathione peroxidase activity was similar in platelets and liver, which apparently contains the largest labile pool of selenium in the body. The activity of glutathione S-transferase (selenium-independent glutathione peroxidase) in platelets was low and was not affected by selenium deficiency, even though hepatic transferase was markedly elevated in selenium-deficient rats. Vitamin E deficiency did not affect activities of glutathione peroxidase or glutathione S-transferase in platelets or liver. Determination of glutathione peroxidase activity in platelets apparently is a promising technique for assessing selenium status and, possibly, for measuring selenium bioavailability. |
| doi_str_mv | 10.1093/jn/113.1.55 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80360145</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022316623254188</els_id><sourcerecordid>80360145</sourcerecordid><originalsourceid>FETCH-LOGICAL-c457t-71cae235ef28b577a2bc7c695890bf03e4f83d08167ee036d01f800e5c2b8d8d3</originalsourceid><addsrcrecordid>eNptkEFP3DAQha2KCra0p54rfOoFZZmx14lzRKhQJCQQC2fLsSetV1kHbAfBv2_ornrqaQ7ve-9pHmNfEZYIrTzbxDNEucSlUh_YAtUKqxoBDtgCQIhKYl0fsU85bwAAV60-ZIe1FkK3uGC3d4MtNFDhV8NUbPkdxkj8jtL4GrzNxM9dCS-hvHGbuY38Onp65WPP17MphmnL17NryjxEfm9L_sw-9nbI9GV_j9nj5Y-Hi5_Vze3V9cX5TeVWqilVg86SkIp6oTvVNFZ0rnF1q3QLXQ-SVr2WHjTWDRHI2gP2GoCUE5322stj9n2X-5TG54lyMduQHQ2DjTRO2ejZND-rZvB0B7o05pyoN08pbG16MwjmfT6ziWaez6BR7_S3fezUbcn_Y_d7zfrJTu_taOyvFLJ5XAtACUK1DfztUzuC5u9fAiWTXaDoyIdErhg_hv82_wHbVoWq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80360145</pqid></control><display><type>article</type><title>Platelet Glutathione Peroxidase Activity as an Index of Selenium Status in Rats</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Levander, Orville A. ; DeLoach, Donna P. ; Morris, Virginia C. ; Moser, Phylis B.</creator><creatorcontrib>Levander, Orville A. ; DeLoach, Donna P. ; Morris, Virginia C. ; Moser, Phylis B.</creatorcontrib><description>Glutathione peroxidase activity in platelets increased stepwise in selenium-depleted rats that were repleted with graded levels of dietary sodium selenite. In a 3-phase depletion/repletion/depletion feeding study, glutathione peroxidase activity was similar in platelets and liver, which apparently contains the largest labile pool of selenium in the body. The activity of glutathione S-transferase (selenium-independent glutathione peroxidase) in platelets was low and was not affected by selenium deficiency, even though hepatic transferase was markedly elevated in selenium-deficient rats. Vitamin E deficiency did not affect activities of glutathione peroxidase or glutathione S-transferase in platelets or liver. Determination of glutathione peroxidase activity in platelets apparently is a promising technique for assessing selenium status and, possibly, for measuring selenium bioavailability.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/113.1.55</identifier><identifier>PMID: 6822891</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Biological Availability ; Blood Platelets - enzymology ; Diet ; glutathione peroxidase ; Glutathione Peroxidase - blood ; Glutathione Peroxidase - metabolism ; Glutathione Transferase - metabolism ; human nutrition ; Liver - enzymology ; Male ; nutrition physiology ; Peroxidases - blood ; platelets ; Rats ; Rats, Inbred F344 ; selenium ; Selenium - administration & dosage ; Selenium - deficiency ; Selenium - metabolism ; selenium status ; vitamin E</subject><ispartof>The Journal of nutrition, 1983-01, Vol.113 (1), p.55-63</ispartof><rights>1983 American Society for Nutrition.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-71cae235ef28b577a2bc7c695890bf03e4f83d08167ee036d01f800e5c2b8d8d3</citedby><cites>FETCH-LOGICAL-c457t-71cae235ef28b577a2bc7c695890bf03e4f83d08167ee036d01f800e5c2b8d8d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6822891$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Levander, Orville A.</creatorcontrib><creatorcontrib>DeLoach, Donna P.</creatorcontrib><creatorcontrib>Morris, Virginia C.</creatorcontrib><creatorcontrib>Moser, Phylis B.</creatorcontrib><title>Platelet Glutathione Peroxidase Activity as an Index of Selenium Status in Rats</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Glutathione peroxidase activity in platelets increased stepwise in selenium-depleted rats that were repleted with graded levels of dietary sodium selenite. In a 3-phase depletion/repletion/depletion feeding study, glutathione peroxidase activity was similar in platelets and liver, which apparently contains the largest labile pool of selenium in the body. The activity of glutathione S-transferase (selenium-independent glutathione peroxidase) in platelets was low and was not affected by selenium deficiency, even though hepatic transferase was markedly elevated in selenium-deficient rats. Vitamin E deficiency did not affect activities of glutathione peroxidase or glutathione S-transferase in platelets or liver. Determination of glutathione peroxidase activity in platelets apparently is a promising technique for assessing selenium status and, possibly, for measuring selenium bioavailability.</description><subject>Animals</subject><subject>Biological Availability</subject><subject>Blood Platelets - enzymology</subject><subject>Diet</subject><subject>glutathione peroxidase</subject><subject>Glutathione Peroxidase - blood</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Glutathione Transferase - metabolism</subject><subject>human nutrition</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>nutrition physiology</subject><subject>Peroxidases - blood</subject><subject>platelets</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>selenium</subject><subject>Selenium - administration & dosage</subject><subject>Selenium - deficiency</subject><subject>Selenium - metabolism</subject><subject>selenium status</subject><subject>vitamin E</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEFP3DAQha2KCra0p54rfOoFZZmx14lzRKhQJCQQC2fLsSetV1kHbAfBv2_ornrqaQ7ve-9pHmNfEZYIrTzbxDNEucSlUh_YAtUKqxoBDtgCQIhKYl0fsU85bwAAV60-ZIe1FkK3uGC3d4MtNFDhV8NUbPkdxkj8jtL4GrzNxM9dCS-hvHGbuY38Onp65WPP17MphmnL17NryjxEfm9L_sw-9nbI9GV_j9nj5Y-Hi5_Vze3V9cX5TeVWqilVg86SkIp6oTvVNFZ0rnF1q3QLXQ-SVr2WHjTWDRHI2gP2GoCUE5322stj9n2X-5TG54lyMduQHQ2DjTRO2ejZND-rZvB0B7o05pyoN08pbG16MwjmfT6ziWaez6BR7_S3fezUbcn_Y_d7zfrJTu_taOyvFLJ5XAtACUK1DfztUzuC5u9fAiWTXaDoyIdErhg_hv82_wHbVoWq</recordid><startdate>198301</startdate><enddate>198301</enddate><creator>Levander, Orville A.</creator><creator>DeLoach, Donna P.</creator><creator>Morris, Virginia C.</creator><creator>Moser, Phylis B.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198301</creationdate><title>Platelet Glutathione Peroxidase Activity as an Index of Selenium Status in Rats</title><author>Levander, Orville A. ; DeLoach, Donna P. ; Morris, Virginia C. ; Moser, Phylis B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c457t-71cae235ef28b577a2bc7c695890bf03e4f83d08167ee036d01f800e5c2b8d8d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Biological Availability</topic><topic>Blood Platelets - enzymology</topic><topic>Diet</topic><topic>glutathione peroxidase</topic><topic>Glutathione Peroxidase - blood</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Glutathione Transferase - metabolism</topic><topic>human nutrition</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>nutrition physiology</topic><topic>Peroxidases - blood</topic><topic>platelets</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>selenium</topic><topic>Selenium - administration & dosage</topic><topic>Selenium - deficiency</topic><topic>Selenium - metabolism</topic><topic>selenium status</topic><topic>vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Levander, Orville A.</creatorcontrib><creatorcontrib>DeLoach, Donna P.</creatorcontrib><creatorcontrib>Morris, Virginia C.</creatorcontrib><creatorcontrib>Moser, Phylis B.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Levander, Orville A.</au><au>DeLoach, Donna P.</au><au>Morris, Virginia C.</au><au>Moser, Phylis B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet Glutathione Peroxidase Activity as an Index of Selenium Status in Rats</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1983-01</date><risdate>1983</risdate><volume>113</volume><issue>1</issue><spage>55</spage><epage>63</epage><pages>55-63</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Glutathione peroxidase activity in platelets increased stepwise in selenium-depleted rats that were repleted with graded levels of dietary sodium selenite. In a 3-phase depletion/repletion/depletion feeding study, glutathione peroxidase activity was similar in platelets and liver, which apparently contains the largest labile pool of selenium in the body. The activity of glutathione S-transferase (selenium-independent glutathione peroxidase) in platelets was low and was not affected by selenium deficiency, even though hepatic transferase was markedly elevated in selenium-deficient rats. Vitamin E deficiency did not affect activities of glutathione peroxidase or glutathione S-transferase in platelets or liver. Determination of glutathione peroxidase activity in platelets apparently is a promising technique for assessing selenium status and, possibly, for measuring selenium bioavailability.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6822891</pmid><doi>10.1093/jn/113.1.55</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 1983-01, Vol.113 (1), p.55-63 |
| issn | 0022-3166 1541-6100 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80360145 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Biological Availability Blood Platelets - enzymology Diet glutathione peroxidase Glutathione Peroxidase - blood Glutathione Peroxidase - metabolism Glutathione Transferase - metabolism human nutrition Liver - enzymology Male nutrition physiology Peroxidases - blood platelets Rats Rats, Inbred F344 selenium Selenium - administration & dosage Selenium - deficiency Selenium - metabolism selenium status vitamin E |
| title | Platelet Glutathione Peroxidase Activity as an Index of Selenium Status in Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T21%3A49%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Platelet%20Glutathione%20Peroxidase%20Activity%20as%20an%20Index%20of%20Selenium%20Status%20in%20Rats&rft.jtitle=The%20Journal%20of%20nutrition&rft.au=Levander,%20Orville%20A.&rft.date=1983-01&rft.volume=113&rft.issue=1&rft.spage=55&rft.epage=63&rft.pages=55-63&rft.issn=0022-3166&rft.eissn=1541-6100&rft_id=info:doi/10.1093/jn/113.1.55&rft_dat=%3Cproquest_cross%3E80360145%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80360145&rft_id=info:pmid/6822891&rft_els_id=S0022316623254188&rfr_iscdi=true |