Vitamin E supplementation and periventricular hemorrhage in the newborn
In a randomized controlled trial preterm babies received 20 mg vitamin E/kg im soon after birth (day 0) and at 24 and 48 h. The mean ±SD plasma vitamin E level on day 0 was identical in supplemented and control groups (9.98 ± 4.88 µmol/L) and rose progressively only in supplemented babies reaching a...
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| Veröffentlicht in: | The American journal of clinical nutrition 1991-01, Vol.53 (1), p.370S-372S |
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| container_title | The American journal of clinical nutrition |
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| creator | Chiswick, M Gladman, G Sinha, S Toner, N Davies, J |
| description | In a randomized controlled trial preterm babies received 20 mg vitamin E/kg im soon after birth (day 0) and at 24 and 48 h. The mean ±SD plasma vitamin E level on day 0 was identical in supplemented and control groups (9.98 ± 4.88 µmol/L) and rose progressively only in supplemented babies reaching a peak of 69.2 ± 21.36 µmol/L at 72 h. Supplemented babies had a lower incidence of intraventricular hemorrhage (IVH) diagnosed by ultrasound (9/102, 8.8%) than the control group (37/108, 34.3%; 95% CI for difference in incidence, 1536%). In a subsequent uncontrolled study using the same vitamin E preparation, a single dose of 20 mg/kg was given soon after birth to preterm babies. The peak mean ± SD plasma level was 32.97 ± 13.47 µmol/L at 48 h. The incidence of IVH (16/121, 13.2%) was lower than in historical control from the randomized trial (95% CI for difference; 10.2–31.8%) in spite of the single-dose group having more clinical risk factors for IVH. We conclude that vitamin E protects against IVH in preterm babies. |
| doi_str_mv | 10.1093/ajcn/53.1.370S |
| format | Article |
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The mean ±SD plasma vitamin E level on day 0 was identical in supplemented and control groups (9.98 ± 4.88 µmol/L) and rose progressively only in supplemented babies reaching a peak of 69.2 ± 21.36 µmol/L at 72 h. Supplemented babies had a lower incidence of intraventricular hemorrhage (IVH) diagnosed by ultrasound (9/102, 8.8%) than the control group (37/108, 34.3%; 95% CI for difference in incidence, 1536%). In a subsequent uncontrolled study using the same vitamin E preparation, a single dose of 20 mg/kg was given soon after birth to preterm babies. The peak mean ± SD plasma level was 32.97 ± 13.47 µmol/L at 48 h. The incidence of IVH (16/121, 13.2%) was lower than in historical control from the randomized trial (95% CI for difference; 10.2–31.8%) in spite of the single-dose group having more clinical risk factors for IVH. We conclude that vitamin E protects against IVH in preterm babies.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/53.1.370S</identifier><identifier>PMID: 1985413</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Biological and medical sciences ; Birth Weight ; brain hemorrhage ; Cerebral Hemorrhage - prevention & control ; Cerebral Ventricles ; General and cellular metabolism. Vitamins ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - prevention & control ; intraventricular hemorrhage ; Medical sciences ; neonatal intensive care ; periventricular hemorrhage ; Pharmacology. Drug treatments ; preterm infants ; Vitamin E ; Vitamin E - blood ; Vitamin E - therapeutic use ; α-tocopherol acetate</subject><ispartof>The American journal of clinical nutrition, 1991-01, Vol.53 (1), p.370S-372S</ispartof><rights>1991 American Society for Nutrition.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-52e248a0aea3a049c3d60365339ae68f7566bdd21662129f36eee61484bafe043</citedby><cites>FETCH-LOGICAL-c408t-52e248a0aea3a049c3d60365339ae68f7566bdd21662129f36eee61484bafe043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>309,310,314,776,780,785,786,4036,4037,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5561888$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1985413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chiswick, M</creatorcontrib><creatorcontrib>Gladman, G</creatorcontrib><creatorcontrib>Sinha, S</creatorcontrib><creatorcontrib>Toner, N</creatorcontrib><creatorcontrib>Davies, J</creatorcontrib><title>Vitamin E supplementation and periventricular hemorrhage in the newborn</title><title>The American journal of clinical nutrition</title><addtitle>Am J Clin Nutr</addtitle><description>In a randomized controlled trial preterm babies received 20 mg vitamin E/kg im soon after birth (day 0) and at 24 and 48 h. The mean ±SD plasma vitamin E level on day 0 was identical in supplemented and control groups (9.98 ± 4.88 µmol/L) and rose progressively only in supplemented babies reaching a peak of 69.2 ± 21.36 µmol/L at 72 h. Supplemented babies had a lower incidence of intraventricular hemorrhage (IVH) diagnosed by ultrasound (9/102, 8.8%) than the control group (37/108, 34.3%; 95% CI for difference in incidence, 1536%). In a subsequent uncontrolled study using the same vitamin E preparation, a single dose of 20 mg/kg was given soon after birth to preterm babies. The peak mean ± SD plasma level was 32.97 ± 13.47 µmol/L at 48 h. The incidence of IVH (16/121, 13.2%) was lower than in historical control from the randomized trial (95% CI for difference; 10.2–31.8%) in spite of the single-dose group having more clinical risk factors for IVH. We conclude that vitamin E protects against IVH in preterm babies.</description><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>brain hemorrhage</subject><subject>Cerebral Hemorrhage - prevention & control</subject><subject>Cerebral Ventricles</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - prevention & control</subject><subject>intraventricular hemorrhage</subject><subject>Medical sciences</subject><subject>neonatal intensive care</subject><subject>periventricular hemorrhage</subject><subject>Pharmacology. Drug treatments</subject><subject>preterm infants</subject><subject>Vitamin E</subject><subject>Vitamin E - blood</subject><subject>Vitamin E - therapeutic use</subject><subject>α-tocopherol acetate</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EKqWwsiFlQGxp7Th2nRFVpSAhMfCxWlfnQl0lTrATEP8eV61gYjrJ99x754eQS0anjBZ8BlvjZoJP2ZTP6fMRGbOCq5RndH5MxpTSLC2YFKfkLIQtpSzLlRyRESuUyBkfk9Wb7aGxLlkmYei6Ght0PfS2dQm4MunQ28_44q0ZavDJBpvW-w28YxJn-g0mDr_WrXfn5KSCOuDFoU7I693yZXGfPj6tHha3j6nJqepTkWG8ACggcKB5YXgpKZeC8wJQqmoupFyXZcakzFhWVFwiomS5ytdQIc35hNzsczvffgwYet3YYLCuwWE7BK1iWvymiuB0DxrfhuCx0p23DfhvzajemdM7c1pwzfTOXBy4OiQP6wbLP3yvKvavD30IBurKgzM2_GJCSKbUbq_aYxgtfFr0OhiLzmBpPZpel63974IfcWOKOA</recordid><startdate>199101</startdate><enddate>199101</enddate><creator>Chiswick, M</creator><creator>Gladman, G</creator><creator>Sinha, S</creator><creator>Toner, N</creator><creator>Davies, J</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199101</creationdate><title>Vitamin E supplementation and periventricular hemorrhage in the newborn</title><author>Chiswick, M ; Gladman, G ; Sinha, S ; Toner, N ; Davies, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-52e248a0aea3a049c3d60365339ae68f7566bdd21662129f36eee61484bafe043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Biological and medical sciences</topic><topic>Birth Weight</topic><topic>brain hemorrhage</topic><topic>Cerebral Hemorrhage - prevention & control</topic><topic>Cerebral Ventricles</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - prevention & control</topic><topic>intraventricular hemorrhage</topic><topic>Medical sciences</topic><topic>neonatal intensive care</topic><topic>periventricular hemorrhage</topic><topic>Pharmacology. Drug treatments</topic><topic>preterm infants</topic><topic>Vitamin E</topic><topic>Vitamin E - blood</topic><topic>Vitamin E - therapeutic use</topic><topic>α-tocopherol acetate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiswick, M</creatorcontrib><creatorcontrib>Gladman, G</creatorcontrib><creatorcontrib>Sinha, S</creatorcontrib><creatorcontrib>Toner, N</creatorcontrib><creatorcontrib>Davies, J</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiswick, M</au><au>Gladman, G</au><au>Sinha, S</au><au>Toner, N</au><au>Davies, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin E supplementation and periventricular hemorrhage in the newborn</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1991-01</date><risdate>1991</risdate><volume>53</volume><issue>1</issue><spage>370S</spage><epage>372S</epage><pages>370S-372S</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>In a randomized controlled trial preterm babies received 20 mg vitamin E/kg im soon after birth (day 0) and at 24 and 48 h. The mean ±SD plasma vitamin E level on day 0 was identical in supplemented and control groups (9.98 ± 4.88 µmol/L) and rose progressively only in supplemented babies reaching a peak of 69.2 ± 21.36 µmol/L at 72 h. Supplemented babies had a lower incidence of intraventricular hemorrhage (IVH) diagnosed by ultrasound (9/102, 8.8%) than the control group (37/108, 34.3%; 95% CI for difference in incidence, 1536%). In a subsequent uncontrolled study using the same vitamin E preparation, a single dose of 20 mg/kg was given soon after birth to preterm babies. The peak mean ± SD plasma level was 32.97 ± 13.47 µmol/L at 48 h. The incidence of IVH (16/121, 13.2%) was lower than in historical control from the randomized trial (95% CI for difference; 10.2–31.8%) in spite of the single-dose group having more clinical risk factors for IVH. We conclude that vitamin E protects against IVH in preterm babies.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>1985413</pmid><doi>10.1093/ajcn/53.1.370S</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Birth Weight brain hemorrhage Cerebral Hemorrhage - prevention & control Cerebral Ventricles General and cellular metabolism. Vitamins Gestational Age Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases - prevention & control intraventricular hemorrhage Medical sciences neonatal intensive care periventricular hemorrhage Pharmacology. Drug treatments preterm infants Vitamin E Vitamin E - blood Vitamin E - therapeutic use α-tocopherol acetate |
| title | Vitamin E supplementation and periventricular hemorrhage in the newborn |
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