Two-dimensional crystallization technique for imaging macromolecules, with application to antigen-antibody-complement complexes

Two-dimensional crystals are formed from macromolecules bound on the surface of a lipid monolayer. A ligand linked to the lipid orientates the binding, and lateral diffusion of the lipids facilitates crystallization. The crystals are suitable for structural analysis by image processing of electron m...

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Veröffentlicht in:	Nature (London) 1983-01, Vol.301 (5896), p.125-129
Hauptverfasser:	Uzgiris, Egidijus E, Kornberg, Roger D
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigen-Antibody Complex Biological and medical sciences Complement System Proteins - immunology Crystalline structure Crystallization Fundamental and applied biological sciences. Psychology Humanities and Social Sciences Macromolecular Substances Methods Microscopy, Electron Molecular biophysics multidisciplinary Science Science (multidisciplinary) Structure in molecular biology X-Ray Diffraction
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