Increased serum opsonic activity and antibody concentration in patients with sickle cell disease after pneumococcal polysaccharide immunization
Opsonic defects have been reported in unimmunized patients with sickle cell disease. We found significant increases (P
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| Veröffentlicht in: | The Journal of pediatrics 1983, Vol.102 (1), p.51-54 |
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| container_end_page | 54 |
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| container_issue | 1 |
| container_start_page | 51 |
| container_title | The Journal of pediatrics |
| container_volume | 102 |
| creator | Chudwin, David S. Wara, Diane W. Matthay, Katherine K. Caulfield, Mary H. Schiffman, Gerald Mentzer, William C. Ammann, Arthur J. |
| description | Opsonic defects have been reported in unimmunized patients with sickle cell disease. We found significant increases (P |
| doi_str_mv | 10.1016/S0022-3476(83)80285-6 |
| format | Article |
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We found significant increases (P<0.001) in serum opsonic activity, measured by a radiolabeled bacterial uptake assay, and in type 7 pneumococcal polysaccharide antibody concentration in 17 such patients 2 years of age or older after pneumococcal polysaccharide immunization. All 17 patients and six healthy controls achieved a type 7 antibody concentration of more than 300 ng antibody nitrogen per milliliter, believed to the protective level of antibody in vivo. Six patients with sickle cell disease less than 2 years of age did not have a significant increase in type 7 antibody concentration after immunization. Only three of these six patients achieved a postimmunization type 7 antibody concentration exceeding 300 ng Ab N/ml. Overall, 16 of 23 patients with sickle cell disease (70%) had a twofold or greater increase in type 7 antibody concentration, and 13 of these (81%) had a corresponding increase in opsonic activity (P<0.001). Thus most patients who responded to pneumococcal polysaccharide immunization had a concurrent increase in opsonic activity in vitro.</description><identifier>ISSN: 0022-3476</identifier><identifier>EISSN: 1097-6833</identifier><identifier>DOI: 10.1016/S0022-3476(83)80285-6</identifier><identifier>PMID: 6848728</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adolescent ; Age Factors ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - immunology ; Antibodies, Bacterial - immunology ; Bacterial Vaccines - administration & dosage ; Child ; Child, Preschool ; Female ; Humans ; Immunization ; Infant ; Male ; Opsonin Proteins - immunology ; Pneumococcal Infections - prevention & control ; Pneumococcal Vaccines ; Streptococcus pneumoniae - immunology</subject><ispartof>The Journal of pediatrics, 1983, Vol.102 (1), p.51-54</ispartof><rights>1982 The C. V. Mosby Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c360t-29893765fd1ea27d678f557570c12145dfb54f39f1df033723d128aa4bc30ea23</citedby><cites>FETCH-LOGICAL-c360t-29893765fd1ea27d678f557570c12145dfb54f39f1df033723d128aa4bc30ea23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022347683802856$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6848728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chudwin, David S.</creatorcontrib><creatorcontrib>Wara, Diane W.</creatorcontrib><creatorcontrib>Matthay, Katherine K.</creatorcontrib><creatorcontrib>Caulfield, Mary H.</creatorcontrib><creatorcontrib>Schiffman, Gerald</creatorcontrib><creatorcontrib>Mentzer, William C.</creatorcontrib><creatorcontrib>Ammann, Arthur J.</creatorcontrib><title>Increased serum opsonic activity and antibody concentration in patients with sickle cell disease after pneumococcal polysaccharide immunization</title><title>The Journal of pediatrics</title><addtitle>J Pediatr</addtitle><description>Opsonic defects have been reported in unimmunized patients with sickle cell disease. We found significant increases (P<0.001) in serum opsonic activity, measured by a radiolabeled bacterial uptake assay, and in type 7 pneumococcal polysaccharide antibody concentration in 17 such patients 2 years of age or older after pneumococcal polysaccharide immunization. All 17 patients and six healthy controls achieved a type 7 antibody concentration of more than 300 ng antibody nitrogen per milliliter, believed to the protective level of antibody in vivo. Six patients with sickle cell disease less than 2 years of age did not have a significant increase in type 7 antibody concentration after immunization. Only three of these six patients achieved a postimmunization type 7 antibody concentration exceeding 300 ng Ab N/ml. Overall, 16 of 23 patients with sickle cell disease (70%) had a twofold or greater increase in type 7 antibody concentration, and 13 of these (81%) had a corresponding increase in opsonic activity (P<0.001). Thus most patients who responded to pneumococcal polysaccharide immunization had a concurrent increase in opsonic activity in vitro.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - immunology</subject><subject>Antibodies, Bacterial - immunology</subject><subject>Bacterial Vaccines - administration & dosage</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Humans</subject><subject>Immunization</subject><subject>Infant</subject><subject>Male</subject><subject>Opsonin Proteins - immunology</subject><subject>Pneumococcal Infections - prevention & control</subject><subject>Pneumococcal Vaccines</subject><subject>Streptococcus pneumoniae - immunology</subject><issn>0022-3476</issn><issn>1097-6833</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUcuO1DAQtBBoGRY-YSWfEBwC7TiJnRNCKx4rrcQBOFuedkdrSOxgO4uGn-CXSWZGe-VgteWuqnZXMXYl4I0A0b39ClDXlWxU90rL1xpq3VbdI7YT0Kuq01I-ZrsHyFP2LOcfANA3ABfsotONVrXesb83ARPZTI5nSsvE45xj8MgtFn_vy4Hb4NZT_D66A8cYkEJJtvgYuA98Xm_rQ-a_fbnj2ePPkTjSOHLn86bL7VAo8TnQMkWMiHbkcxwP2SLe2eQdcT9NS_B_jprP2ZPBjplenOsl-_7xw7frz9Xtl0831-9vK5QdlKrudS9V1w5OkK2V65Qe2la1ClDUomndsG-bQfaDcANIqWrpRK2tbfYoYWXIS_bypDun-GuhXMzk8_ZvGygu2WiQTQ_QrcD2BMQUc040mDn5yaaDEWC2IMwxCLO5bLQ0xyDMxrs6D1j2E7kH1tn5tf_u1Kd1y3tPyWRcnURyPhEW46L_z4R_G4ab3Q</recordid><startdate>1983</startdate><enddate>1983</enddate><creator>Chudwin, David S.</creator><creator>Wara, Diane W.</creator><creator>Matthay, Katherine K.</creator><creator>Caulfield, Mary H.</creator><creator>Schiffman, Gerald</creator><creator>Mentzer, William C.</creator><creator>Ammann, Arthur J.</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1983</creationdate><title>Increased serum opsonic activity and antibody concentration in patients with sickle cell disease after pneumococcal polysaccharide immunization</title><author>Chudwin, David S. ; Wara, Diane W. ; Matthay, Katherine K. ; Caulfield, Mary H. ; Schiffman, Gerald ; Mentzer, William C. ; Ammann, Arthur J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c360t-29893765fd1ea27d678f557570c12145dfb54f39f1df033723d128aa4bc30ea23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - immunology</topic><topic>Antibodies, Bacterial - immunology</topic><topic>Bacterial Vaccines - administration & dosage</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Humans</topic><topic>Immunization</topic><topic>Infant</topic><topic>Male</topic><topic>Opsonin Proteins - immunology</topic><topic>Pneumococcal Infections - prevention & control</topic><topic>Pneumococcal Vaccines</topic><topic>Streptococcus pneumoniae - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chudwin, David S.</creatorcontrib><creatorcontrib>Wara, Diane W.</creatorcontrib><creatorcontrib>Matthay, Katherine K.</creatorcontrib><creatorcontrib>Caulfield, Mary H.</creatorcontrib><creatorcontrib>Schiffman, Gerald</creatorcontrib><creatorcontrib>Mentzer, William C.</creatorcontrib><creatorcontrib>Ammann, Arthur J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of pediatrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chudwin, David S.</au><au>Wara, Diane W.</au><au>Matthay, Katherine K.</au><au>Caulfield, Mary H.</au><au>Schiffman, Gerald</au><au>Mentzer, William C.</au><au>Ammann, Arthur J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased serum opsonic activity and antibody concentration in patients with sickle cell disease after pneumococcal polysaccharide immunization</atitle><jtitle>The Journal of pediatrics</jtitle><addtitle>J Pediatr</addtitle><date>1983</date><risdate>1983</risdate><volume>102</volume><issue>1</issue><spage>51</spage><epage>54</epage><pages>51-54</pages><issn>0022-3476</issn><eissn>1097-6833</eissn><abstract>Opsonic defects have been reported in unimmunized patients with sickle cell disease. We found significant increases (P<0.001) in serum opsonic activity, measured by a radiolabeled bacterial uptake assay, and in type 7 pneumococcal polysaccharide antibody concentration in 17 such patients 2 years of age or older after pneumococcal polysaccharide immunization. All 17 patients and six healthy controls achieved a type 7 antibody concentration of more than 300 ng antibody nitrogen per milliliter, believed to the protective level of antibody in vivo. Six patients with sickle cell disease less than 2 years of age did not have a significant increase in type 7 antibody concentration after immunization. Only three of these six patients achieved a postimmunization type 7 antibody concentration exceeding 300 ng Ab N/ml. Overall, 16 of 23 patients with sickle cell disease (70%) had a twofold or greater increase in type 7 antibody concentration, and 13 of these (81%) had a corresponding increase in opsonic activity (P<0.001). Thus most patients who responded to pneumococcal polysaccharide immunization had a concurrent increase in opsonic activity in vitro.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>6848728</pmid><doi>10.1016/S0022-3476(83)80285-6</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0022-3476 |
| ispartof | The Journal of pediatrics, 1983, Vol.102 (1), p.51-54 |
| issn | 0022-3476 1097-6833 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Age Factors Anemia, Sickle Cell - complications Anemia, Sickle Cell - immunology Antibodies, Bacterial - immunology Bacterial Vaccines - administration & dosage Child Child, Preschool Female Humans Immunization Infant Male Opsonin Proteins - immunology Pneumococcal Infections - prevention & control Pneumococcal Vaccines Streptococcus pneumoniae - immunology |
| title | Increased serum opsonic activity and antibody concentration in patients with sickle cell disease after pneumococcal polysaccharide immunization |
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