Role of N-methylolpentamethylmelamine in the metabolic activation of hexamethylmelamine

Hexamethylmelamine (HMM) is metabolized by rat hepatic microsomal preparations to reactive species which covalently bind to microsomal protein and to calf thymus DNA added to microsomal incubation mixtures. Covalent binding to macromolecules is dependent on the presence of molecular oxygen and reduc...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1983-02, Vol.43 (2), p.500-504
Hauptverfasser:	Ames, M M, Sanders, M E, Tiede, W S
Format:	Artikel
Sprache:	eng
Schlagworte:	Altretamine - analogs & derivatives Altretamine - metabolism Animals Carbon Radioisotopes Cytochrome P-450 Enzyme System - metabolism Kinetics Male Microsomes, Liver - metabolism NADP - metabolism Protein Binding Proteins - metabolism Rats Rats, Inbred Strains Triazines - metabolism
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