Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders
The authors found that platelet serotonin concentrations were significantly elevated in patients with chronic schizophrenia and in patients with bipolar major depressive disorder. High-affinity serotonin uptake was significantly reduced only in patients with bipolar major depressive disorder. Thromb...
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| Veröffentlicht in: | The American journal of psychiatry 1983-01, Vol.140 (1), p.26-30 |
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| container_title | The American journal of psychiatry |
| container_volume | 140 |
| creator | Stahl, S M Woo, D J Mefford, I N Berger, P A Ciaranello, R D |
| description | The authors found that platelet serotonin concentrations were
significantly elevated in patients with chronic schizophrenia and in
patients with bipolar major depressive disorder. High-affinity serotonin
uptake was significantly reduced only in patients with bipolar major
depressive disorder. Thrombin-induced release of serotonin from platelets
in any patient group was not different from that of normal control
subjects. Platelet serotonin storage in chronic schizophrenic patients was
also not different from that in normal control subjects. These platelet
findings could not be explained by age, sex, or medication variables. The
authors suggest that the pharmacodynamics of platelet serotonin may be
different in chronic schizophrenia than in bipolar major depressive
disorder. |
| doi_str_mv | 10.1176/ajp.140.1.26 |
| format | Article |
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significantly elevated in patients with chronic schizophrenia and in
patients with bipolar major depressive disorder. High-affinity serotonin
uptake was significantly reduced only in patients with bipolar major
depressive disorder. Thrombin-induced release of serotonin from platelets
in any patient group was not different from that of normal control
subjects. Platelet serotonin storage in chronic schizophrenic patients was
also not different from that in normal control subjects. These platelet
findings could not be explained by age, sex, or medication variables. The
authors suggest that the pharmacodynamics of platelet serotonin may be
different in chronic schizophrenia than in bipolar major depressive
disorder.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.140.1.26</identifier><identifier>PMID: 6401198</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adult ; Bipolar Disorder - blood ; Blood Platelets - metabolism ; Chronic Disease ; Depressive Disorder - blood ; Female ; Humans ; Lithium - therapeutic use ; Lithium Carbonate ; Male ; Middle Aged ; Mood Disorders - blood ; Psychotic Disorders - blood ; Psychotropic Drugs - therapeutic use ; Schizophrenia - blood ; Serotonin - blood ; Serotonin - metabolism</subject><ispartof>The American journal of psychiatry, 1983-01, Vol.140 (1), p.26-30</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a348t-1f003ac10f168e2b574eda2b46af7cf8324a3d32705ed01834615f9c2d34bdf03</citedby><cites>FETCH-LOGICAL-a348t-1f003ac10f168e2b574eda2b46af7cf8324a3d32705ed01834615f9c2d34bdf03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.140.1.26$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.140.1.26$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>315,782,786,2863,21638,27878,27933,27934,77801,77802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6401198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stahl, S M</creatorcontrib><creatorcontrib>Woo, D J</creatorcontrib><creatorcontrib>Mefford, I N</creatorcontrib><creatorcontrib>Berger, P A</creatorcontrib><creatorcontrib>Ciaranello, R D</creatorcontrib><title>Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>The authors found that platelet serotonin concentrations were
significantly elevated in patients with chronic schizophrenia and in
patients with bipolar major depressive disorder. High-affinity serotonin
uptake was significantly reduced only in patients with bipolar major
depressive disorder. Thrombin-induced release of serotonin from platelets
in any patient group was not different from that of normal control
subjects. Platelet serotonin storage in chronic schizophrenic patients was
also not different from that in normal control subjects. These platelet
findings could not be explained by age, sex, or medication variables. The
authors suggest that the pharmacodynamics of platelet serotonin may be
different in chronic schizophrenia than in bipolar major depressive
disorder.</description><subject>Adult</subject><subject>Bipolar Disorder - blood</subject><subject>Blood Platelets - metabolism</subject><subject>Chronic Disease</subject><subject>Depressive Disorder - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Lithium - therapeutic use</subject><subject>Lithium Carbonate</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mood Disorders - blood</subject><subject>Psychotic Disorders - blood</subject><subject>Psychotropic Drugs - therapeutic use</subject><subject>Schizophrenia - blood</subject><subject>Serotonin - blood</subject><subject>Serotonin - metabolism</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNptkMtLxDAQxoMo67p68yoUBEGwax59HmXxBQteFLyFtJmwWdsmJq2w_vVm3SIiMocw-X7zzfAhdErwnJA8uxZrOydJaOY020NTkrI0zikt9tEUY0zjMmWvh-jI-3VoMcvpBE2yBBNSFlNUP2wsOA_O9KaDVotIdDKyjeihgT4aBd1Fg-3FG3yrLkjCQxR-fb3Sn8auHHTjqFAK6l5_QCS1N04G82N0oETj4WR8Z-jl7vZ58RAvn-4fFzfLWLCk6GOiwnWiJliRrABapXkCUtAqyYTKa1UwmggmGc1xChKTgiUZSVVZU8mSSirMZuhi52udeR_A97zVvoamER2YwfMChz0Ub8HzP-DaDK4Lt3HCCM5CFWWgrnZU7Yz3DhS3TrfCbTjBfJs8D8nzkDwnnGYBPxtNh6oF-QOPUQf9cqcLa_Wvhf95fQHwPY0o</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Stahl, S M</creator><creator>Woo, D J</creator><creator>Mefford, I N</creator><creator>Berger, P A</creator><creator>Ciaranello, R D</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>19830101</creationdate><title>Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders</title><author>Stahl, S M ; Woo, D J ; Mefford, I N ; Berger, P A ; Ciaranello, R D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a348t-1f003ac10f168e2b574eda2b46af7cf8324a3d32705ed01834615f9c2d34bdf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Adult</topic><topic>Bipolar Disorder - blood</topic><topic>Blood Platelets - metabolism</topic><topic>Chronic Disease</topic><topic>Depressive Disorder - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Lithium - therapeutic use</topic><topic>Lithium Carbonate</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mood Disorders - blood</topic><topic>Psychotic Disorders - blood</topic><topic>Psychotropic Drugs - therapeutic use</topic><topic>Schizophrenia - blood</topic><topic>Serotonin - blood</topic><topic>Serotonin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stahl, S M</creatorcontrib><creatorcontrib>Woo, D J</creatorcontrib><creatorcontrib>Mefford, I N</creatorcontrib><creatorcontrib>Berger, P A</creatorcontrib><creatorcontrib>Ciaranello, R D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Periodicals Index Online Segment 13</collection><collection>Periodicals Index Online Segment 14</collection><collection>Periodicals Index Online Segment 27</collection><collection>Periodicals Index Online</collection><collection>Primary Sources Access—Foundation Edition (Plan E) - 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significantly elevated in patients with chronic schizophrenia and in
patients with bipolar major depressive disorder. High-affinity serotonin
uptake was significantly reduced only in patients with bipolar major
depressive disorder. Thrombin-induced release of serotonin from platelets
in any patient group was not different from that of normal control
subjects. Platelet serotonin storage in chronic schizophrenic patients was
also not different from that in normal control subjects. These platelet
findings could not be explained by age, sex, or medication variables. The
authors suggest that the pharmacodynamics of platelet serotonin may be
different in chronic schizophrenia than in bipolar major depressive
disorder.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>6401198</pmid><doi>10.1176/ajp.140.1.26</doi><tpages>5</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Bipolar Disorder - blood Blood Platelets - metabolism Chronic Disease Depressive Disorder - blood Female Humans Lithium - therapeutic use Lithium Carbonate Male Middle Aged Mood Disorders - blood Psychotic Disorders - blood Psychotropic Drugs - therapeutic use Schizophrenia - blood Serotonin - blood Serotonin - metabolism |
| title | Hyperserotonemia and platelet serotonin uptake and release in schizophrenia and affective disorders |
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