Antibody-directed fibrinolysis: a bispecific (Fab')2 that binds to fibrin and tissue plasminogen activator

A bispecific (Fab')2 molecule was constructed by linking the monovalent Fab' from an anti-fibrin monoclonal antibody to the Fab' from an anti tissue plasminogen activator (tPA, single chain) monoclonal antibody by means of inter-heavy-chain disulfide bonds. An immunochemical complex c...

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Veröffentlicht in:	Bioconjugate chemistry 1990-07, Vol.1 (4), p.274-277
Hauptverfasser:	Runge, Marschall S, Bode, Christoph, Savard, Christopher E, Matsueda, Gary R, Haber, Edgar
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - pharmacology Cross-Linking Reagents Electrophoresis, Polyacrylamide Gel - methods Fibrin - immunology Fibrin - metabolism Fibrinolysis Immunoglobulin Fab Fragments - metabolism Immunoglobulin Fragments - metabolism Tissue Plasminogen Activator - immunology Tissue Plasminogen Activator - metabolism
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