[ 3H]Vesamicol binding in human brain cholinergic deficiency disorders

We measured the binding of the vesicular acetylcholine transport blocker [ 3H]vesamicol (2-[4-phenylpiperidino] cyclohexanol; AH-5183) to autopsied frontal cortex and amygdala of patients from 4 disorders having a marked brain cholinergic reduction, namely Alzheimer's disease, Parkinson's...

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Veröffentlicht in:	Neuroscience letters 1990-09, Vol.117 (3), p.347-352
Hauptverfasser:	Kish, Stephen J., Distefano, Linda M., Dozic̆, Slobodan, Robitaille, Yves, Rajput, Ali, Deck, John H.N., Hornykiewicz, Oleh
Format:	Artikel
Sprache:	eng
Schlagworte:	[ 3H]Vesamicol Acetylcholine Acetylcholine - metabolism Adult Aged AH-5183 Alzheimer Disease - metabolism Alzheimer's disease Amygdala - metabolism Autonomic Nervous System Diseases - metabolism Biological and medical sciences Brain Brain Chemistry Cerebral Cortex - metabolism Choline acetyltransferase Choline O-Acetyltransferase - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Down Syndrome - metabolism Humans Medical sciences Middle Aged Neurology Neuromuscular Depolarizing Agents - metabolism Olivopontocerebellar Atrophies - metabolism Parasympathetic Nervous System - metabolism Parkinson Disease - metabolism Piperidines - metabolism
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