Column-switching high-performance liquid chromatographic (HPLC) determination of hydrochlorothiazide in rat, dog, and human plasma

A fully automated HPLC assay for hydrochlorothiazide in plasma has been developed using a column-switching technique. The method involves direct injection of plasma to the extraction column for sample cleanup followed by switching onto the analytical column. Good precision, accuracy, and linearity w...

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Veröffentlicht in:	Pharmaceutical research 1990-12, Vol.7 (12), p.1257-1261
Hauptverfasser:	BE-SHENG KUO, MANDAGERE, A, OSBORNE, D. R, KIN-KAI HWANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Chromatography, High Pressure Liquid - standards Dogs Evaluation Studies as Topic General pharmacology Humans Hydrochlorothiazide - blood Medical sciences Pharmacology. Drug treatments Rats
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