Column-switching high-performance liquid chromatographic (HPLC) determination of hydrochlorothiazide in rat, dog, and human plasma

A fully automated HPLC assay for hydrochlorothiazide in plasma has been developed using a column-switching technique. The method involves direct injection of plasma to the extraction column for sample cleanup followed by switching onto the analytical column. Good precision, accuracy, and linearity w...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical research 1990-12, Vol.7 (12), p.1257-1261
Hauptverfasser:	BE-SHENG KUO, MANDAGERE, A, OSBORNE, D. R, KIN-KAI HWANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Chromatography, High Pressure Liquid - standards Dogs Evaluation Studies as Topic General pharmacology Humans Hydrochlorothiazide - blood Medical sciences Pharmacology. Drug treatments Rats
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page	1261
container_issue	12
container_start_page	1257
container_title	Pharmaceutical research
container_volume	7
creator	BE-SHENG KUO MANDAGERE, A OSBORNE, D. R KIN-KAI HWANG
description	A fully automated HPLC assay for hydrochlorothiazide in plasma has been developed using a column-switching technique. The method involves direct injection of plasma to the extraction column for sample cleanup followed by switching onto the analytical column. Good precision, accuracy, and linearity were obtained over a range of 25 to 2000 ng/ml in rat, dog, and human plasma. The column-switching method has also been validated by comparison with a conventional HPLC method requiring a cumbersome plasma extraction procedure. Since the method is simple, rapid, and reproducible, it is useful for determination of hydrochlorothiazide levels in animal and human plasma.
doi_str_mv	10.1023/A:1015933820971
format	Article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_80342024</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>80342024</sourcerecordid><originalsourceid>FETCH-LOGICAL-p236t-f20dddb2278d0f650ebe6387d6ca37532401373790285f72f7e8fb6e9698c57d3</originalsourceid><addsrcrecordid>eNo9kE1LwzAAhoMoc07PnoRcFIVV89E2qbdR1AkDPSh4K1k-lkjbdEmLzKO_3ILD03t4H57DA8A5RrcYEXq3uMcIZwWlnKCC4QMwxRmjSYHSj0MwRYykCWcpPgYnMX4ihDgu0gmYjHCW5XQKfkpfD02bxC_XS-vaDbRuY5NOB-NDI1qpYe22g1NQ2uAb0ftNEJ11El4vX1flDVS616Fxreidb6E30O5U8NLWPvjeOvHtlIauhUH0c6j8Zg5Fq6AdRjfsahEbcQqOjKijPtvvDLw_PryVy2T18vRcLlZJR2jeJ4YgpdSaEMYVMnmG9FrnlDOVS0FZRkmKMGWUFYjwzDBimOZmnesiL7jMmKIzcPXn7YLfDjr2VeOi1HUtWu2HWHFEU4JIOoIXe3BYN1pVXXCNCLtqH238L_e_iFLUJoyZXPzHxsKYMIbpLzxqfKw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80342024</pqid></control><display><type>article</type><title>Column-switching high-performance liquid chromatographic (HPLC) determination of hydrochlorothiazide in rat, dog, and human plasma</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>BE-SHENG KUO ; MANDAGERE, A ; OSBORNE, D. R ; KIN-KAI HWANG</creator><creatorcontrib>BE-SHENG KUO ; MANDAGERE, A ; OSBORNE, D. R ; KIN-KAI HWANG</creatorcontrib><description>A fully automated HPLC assay for hydrochlorothiazide in plasma has been developed using a column-switching technique. The method involves direct injection of plasma to the extraction column for sample cleanup followed by switching onto the analytical column. Good precision, accuracy, and linearity were obtained over a range of 25 to 2000 ng/ml in rat, dog, and human plasma. The column-switching method has also been validated by comparison with a conventional HPLC method requiring a cumbersome plasma extraction procedure. Since the method is simple, rapid, and reproducible, it is useful for determination of hydrochlorothiazide levels in animal and human plasma.</description><identifier>ISSN: 0724-8741</identifier><identifier>EISSN: 1573-904X</identifier><identifier>DOI: 10.1023/A:1015933820971</identifier><identifier>PMID: 2095563</identifier><identifier>CODEN: PHREEB</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Analysis ; Animals ; Biological and medical sciences ; Chromatography, High Pressure Liquid - methods ; Chromatography, High Pressure Liquid - standards ; Dogs ; Evaluation Studies as Topic ; General pharmacology ; Humans ; Hydrochlorothiazide - blood ; Medical sciences ; Pharmacology. Drug treatments ; Rats</subject><ispartof>Pharmaceutical research, 1990-12, Vol.7 (12), p.1257-1261</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19412771$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2095563$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BE-SHENG KUO</creatorcontrib><creatorcontrib>MANDAGERE, A</creatorcontrib><creatorcontrib>OSBORNE, D. R</creatorcontrib><creatorcontrib>KIN-KAI HWANG</creatorcontrib><title>Column-switching high-performance liquid chromatographic (HPLC) determination of hydrochlorothiazide in rat, dog, and human plasma</title><title>Pharmaceutical research</title><addtitle>Pharm Res</addtitle><description>A fully automated HPLC assay for hydrochlorothiazide in plasma has been developed using a column-switching technique. The method involves direct injection of plasma to the extraction column for sample cleanup followed by switching onto the analytical column. Good precision, accuracy, and linearity were obtained over a range of 25 to 2000 ng/ml in rat, dog, and human plasma. The column-switching method has also been validated by comparison with a conventional HPLC method requiring a cumbersome plasma extraction procedure. Since the method is simple, rapid, and reproducible, it is useful for determination of hydrochlorothiazide levels in animal and human plasma.</description><subject>Analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, High Pressure Liquid - standards</subject><subject>Dogs</subject><subject>Evaluation Studies as Topic</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Hydrochlorothiazide - blood</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><issn>0724-8741</issn><issn>1573-904X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kE1LwzAAhoMoc07PnoRcFIVV89E2qbdR1AkDPSh4K1k-lkjbdEmLzKO_3ILD03t4H57DA8A5RrcYEXq3uMcIZwWlnKCC4QMwxRmjSYHSj0MwRYykCWcpPgYnMX4ihDgu0gmYjHCW5XQKfkpfD02bxC_XS-vaDbRuY5NOB-NDI1qpYe22g1NQ2uAb0ftNEJ11El4vX1flDVS616Fxreidb6E30O5U8NLWPvjeOvHtlIauhUH0c6j8Zg5Fq6AdRjfsahEbcQqOjKijPtvvDLw_PryVy2T18vRcLlZJR2jeJ4YgpdSaEMYVMnmG9FrnlDOVS0FZRkmKMGWUFYjwzDBimOZmnesiL7jMmKIzcPXn7YLfDjr2VeOi1HUtWu2HWHFEU4JIOoIXe3BYN1pVXXCNCLtqH238L_e_iFLUJoyZXPzHxsKYMIbpLzxqfKw</recordid><startdate>19901201</startdate><enddate>19901201</enddate><creator>BE-SHENG KUO</creator><creator>MANDAGERE, A</creator><creator>OSBORNE, D. R</creator><creator>KIN-KAI HWANG</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19901201</creationdate><title>Column-switching high-performance liquid chromatographic (HPLC) determination of hydrochlorothiazide in rat, dog, and human plasma</title><author>BE-SHENG KUO ; MANDAGERE, A ; OSBORNE, D. R ; KIN-KAI HWANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p236t-f20dddb2278d0f650ebe6387d6ca37532401373790285f72f7e8fb6e9698c57d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, High Pressure Liquid - standards</topic><topic>Dogs</topic><topic>Evaluation Studies as Topic</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Hydrochlorothiazide - blood</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BE-SHENG KUO</creatorcontrib><creatorcontrib>MANDAGERE, A</creatorcontrib><creatorcontrib>OSBORNE, D. R</creatorcontrib><creatorcontrib>KIN-KAI HWANG</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Pharmaceutical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BE-SHENG KUO</au><au>MANDAGERE, A</au><au>OSBORNE, D. R</au><au>KIN-KAI HWANG</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Column-switching high-performance liquid chromatographic (HPLC) determination of hydrochlorothiazide in rat, dog, and human plasma</atitle><jtitle>Pharmaceutical research</jtitle><addtitle>Pharm Res</addtitle><date>1990-12-01</date><risdate>1990</risdate><volume>7</volume><issue>12</issue><spage>1257</spage><epage>1261</epage><pages>1257-1261</pages><issn>0724-8741</issn><eissn>1573-904X</eissn><coden>PHREEB</coden><abstract>A fully automated HPLC assay for hydrochlorothiazide in plasma has been developed using a column-switching technique. The method involves direct injection of plasma to the extraction column for sample cleanup followed by switching onto the analytical column. Good precision, accuracy, and linearity were obtained over a range of 25 to 2000 ng/ml in rat, dog, and human plasma. The column-switching method has also been validated by comparison with a conventional HPLC method requiring a cumbersome plasma extraction procedure. Since the method is simple, rapid, and reproducible, it is useful for determination of hydrochlorothiazide levels in animal and human plasma.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>2095563</pmid><doi>10.1023/A:1015933820971</doi><tpages>5</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0724-8741
ispartof	Pharmaceutical research, 1990-12, Vol.7 (12), p.1257-1261
issn	0724-8741 1573-904X
language	eng
recordid	cdi_proquest_miscellaneous_80342024
source	MEDLINE; SpringerLink Journals - AutoHoldings
subjects	Analysis Animals Biological and medical sciences Chromatography, High Pressure Liquid - methods Chromatography, High Pressure Liquid - standards Dogs Evaluation Studies as Topic General pharmacology Humans Hydrochlorothiazide - blood Medical sciences Pharmacology. Drug treatments Rats
title	Column-switching high-performance liquid chromatographic (HPLC) determination of hydrochlorothiazide in rat, dog, and human plasma
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T10%3A54%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Column-switching%20high-performance%20liquid%20chromatographic%20(HPLC)%20determination%20of%20hydrochlorothiazide%20in%20rat,%20dog,%20and%20human%20plasma&rft.jtitle=Pharmaceutical%20research&rft.au=BE-SHENG%20KUO&rft.date=1990-12-01&rft.volume=7&rft.issue=12&rft.spage=1257&rft.epage=1261&rft.pages=1257-1261&rft.issn=0724-8741&rft.eissn=1573-904X&rft.coden=PHREEB&rft_id=info:doi/10.1023/A:1015933820971&rft_dat=%3Cproquest_pubme%3E80342024%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80342024&rft_id=info:pmid/2095563&rfr_iscdi=true