Limulus amoebocyte lysate endotoxin test: An aid to the diagnosis in the septic neonate?
A trial was undertaken of the Limulus amoebocyte lysate endotoxin assay for the diagnosis of Gram-negative infection in the pre-term infant. Blood and cerebrospinal fluid (CSF) were tested in 19 neonates of 33 weeks mean gestational age. In the plasma the assay only once detected endotoxin but was p...
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| Veröffentlicht in: | The Journal of infection 1982, Vol.4 (1), p.69-72 |
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| container_title | The Journal of infection |
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| creator | Kelsey, M.C. Lipscomb, A.P. Mowles, J.M. |
| description | A trial was undertaken of the Limulus amoebocyte lysate endotoxin assay for the diagnosis of Gram-negative infection in the pre-term infant. Blood and cerebrospinal fluid (CSF) were tested in 19 neonates of 33 weeks mean gestational age. In the plasma the assay only once detected endotoxin but was positive in the CSF of two cases of meningitis, in one case before cellular changes were present. Endotoxin was detected in the CSF of five other neonates who did not have meningitis but may have had endotoxaemia. |
| doi_str_mv | 10.1016/S0163-4453(82)91104-5 |
| format | Article |
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Blood and cerebrospinal fluid (CSF) were tested in 19 neonates of 33 weeks mean gestational age. In the plasma the assay only once detected endotoxin but was positive in the CSF of two cases of meningitis, in one case before cellular changes were present. Endotoxin was detected in the CSF of five other neonates who did not have meningitis but may have had endotoxaemia.</description><identifier>ISSN: 0163-4453</identifier><identifier>EISSN: 1532-2742</identifier><identifier>DOI: 10.1016/S0163-4453(82)91104-5</identifier><identifier>PMID: 7185978</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Endotoxins - cerebrospinal fluid ; Gestational Age ; Humans ; Infant, Newborn ; Infant, Newborn, Diseases - diagnosis ; Limulus Test ; Meningitis - diagnosis ; Risk ; Sepsis - diagnosis</subject><ispartof>The Journal of infection, 1982, Vol.4 (1), p.69-72</ispartof><rights>1982 The British Society for the Study of Infection</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c275t-7bbcb080cd69be441be6e827096e5637f510a367eab787271a37c26d850e27203</citedby><cites>FETCH-LOGICAL-c275t-7bbcb080cd69be441be6e827096e5637f510a367eab787271a37c26d850e27203</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0163-4453(82)91104-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,4025,27928,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7185978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelsey, M.C.</creatorcontrib><creatorcontrib>Lipscomb, A.P.</creatorcontrib><creatorcontrib>Mowles, J.M.</creatorcontrib><title>Limulus amoebocyte lysate endotoxin test: An aid to the diagnosis in the septic neonate?</title><title>The Journal of infection</title><addtitle>J Infect</addtitle><description>A trial was undertaken of the Limulus amoebocyte lysate endotoxin assay for the diagnosis of Gram-negative infection in the pre-term infant. Blood and cerebrospinal fluid (CSF) were tested in 19 neonates of 33 weeks mean gestational age. In the plasma the assay only once detected endotoxin but was positive in the CSF of two cases of meningitis, in one case before cellular changes were present. Endotoxin was detected in the CSF of five other neonates who did not have meningitis but may have had endotoxaemia.</description><subject>Endotoxins - cerebrospinal fluid</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Infant, Newborn, Diseases - diagnosis</subject><subject>Limulus Test</subject><subject>Meningitis - diagnosis</subject><subject>Risk</subject><subject>Sepsis - diagnosis</subject><issn>0163-4453</issn><issn>1532-2742</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKBDEQhoMoOi6PIOQkemjN0lnaiwziBgMeVPAW0ukajXR3xk5anLc34wxevVRB1f_X8iF0TMk5JVRePOXAi7IU_FSzs4pSUhZiC02o4KxgqmTbaPIn2UP7MX4QQipeyV20q6gWldIT9Drz3diOEdsuQB3cMgFul9HmBH0TUvj2PU4Q0yWe9tj6BqeA0zvgxtu3PkQf8UqQCxEWyTvcQ-iz--oQ7cxtG-Fokw_Qy-3N8_V9MXu8e7iezgrHlEiFqmtXE01cI6saypLWIEEzRSoJQnI1F5RYLhXYWmnFFLVcOSYbLQgwxQg_QCfruYshfI75UNP56KBtbb5kjEYTzmUpWRaKtdANIcYB5mYx-M4OS0OJWRE1v0TNCpfRzPwSNSL7jjcLxrqD5s-1QZj7V-s-5C-_PAwmOg-9g8YP4JJpgv9nww_7X4Us</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Kelsey, M.C.</creator><creator>Lipscomb, A.P.</creator><creator>Mowles, J.M.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Limulus amoebocyte lysate endotoxin test: An aid to the diagnosis in the septic neonate?</title><author>Kelsey, M.C. ; Lipscomb, A.P. ; Mowles, J.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-7bbcb080cd69be441be6e827096e5637f510a367eab787271a37c26d850e27203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Endotoxins - cerebrospinal fluid</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Infant, Newborn, Diseases - diagnosis</topic><topic>Limulus Test</topic><topic>Meningitis - diagnosis</topic><topic>Risk</topic><topic>Sepsis - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kelsey, M.C.</creatorcontrib><creatorcontrib>Lipscomb, A.P.</creatorcontrib><creatorcontrib>Mowles, J.M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kelsey, M.C.</au><au>Lipscomb, A.P.</au><au>Mowles, J.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Limulus amoebocyte lysate endotoxin test: An aid to the diagnosis in the septic neonate?</atitle><jtitle>The Journal of infection</jtitle><addtitle>J Infect</addtitle><date>1982</date><risdate>1982</risdate><volume>4</volume><issue>1</issue><spage>69</spage><epage>72</epage><pages>69-72</pages><issn>0163-4453</issn><eissn>1532-2742</eissn><abstract>A trial was undertaken of the Limulus amoebocyte lysate endotoxin assay for the diagnosis of Gram-negative infection in the pre-term infant. Blood and cerebrospinal fluid (CSF) were tested in 19 neonates of 33 weeks mean gestational age. In the plasma the assay only once detected endotoxin but was positive in the CSF of two cases of meningitis, in one case before cellular changes were present. Endotoxin was detected in the CSF of five other neonates who did not have meningitis but may have had endotoxaemia.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>7185978</pmid><doi>10.1016/S0163-4453(82)91104-5</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0163-4453 |
| ispartof | The Journal of infection, 1982, Vol.4 (1), p.69-72 |
| issn | 0163-4453 1532-2742 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Endotoxins - cerebrospinal fluid Gestational Age Humans Infant, Newborn Infant, Newborn, Diseases - diagnosis Limulus Test Meningitis - diagnosis Risk Sepsis - diagnosis |
| title | Limulus amoebocyte lysate endotoxin test: An aid to the diagnosis in the septic neonate? |
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