Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites : clozapine potently interacts with 5-HT1C sites

We determined the affinity of several typical and atypical antipsychotics for the 5-HT1C and 5-HT2 sites using radioligand binding assays. Most of the antipsychotics tested appeared to bind to 5-HT2 sites with affinities that were fairly high (i.e. pKi values between 7 and 9) and significantly highe...

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