A NOVEL SKELETAL DRUG DELIVERY SYSTEM FOR ANTI-BACTERIAL DRUGS USING SELF-SETTING HYDROXYAPATITE CEMENT

To solve the problem of delivering drugs to skeletal tissue at high enough local concentrations for desirable therapeutic effects, we report a novel approach using a self-setting hydroxyapatite cement, with cephalexin and norfloxacin as model drugs. After setting, the cement was transformed into hyd...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1990/12/25, Vol.38(12), pp.3500-3502
Hauptverfasser:	OTSUKA, Makoto, MATSUDA, Yoshihisa, YU, Duncan, WONG, Joseph, FOX, Jeffery L., HIGUCHI, William I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - administration & dosage Biological and medical sciences cephalexin controlled release drug delivery system Excipients General pharmacology hydroxyapatite Hydroxyapatites - chemistry Medical sciences norfloxacin Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments self-stetting cement X-Ray Diffraction
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