Central and peripheral control of sympathoadrenal activity and energy metabolism in rats
The role of adrenoceptors in the hypothalamus and the peripheral sympathetic nervous system in the regulation of sympathoadrenal activity and glucose and FFA mobilization was investigated in exercising rats. Apparent close relations within the two parts of the sympathoadrenal system and between fact...
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| Veröffentlicht in: | Physiology & behavior 1990-12, Vol.48 (6), p.909-920 |
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| creator | Scheurink, Anton J.W. Steffens, Anton B. |
| description | The role of adrenoceptors in the hypothalamus and the peripheral sympathetic nervous system in the regulation of sympathoadrenal activity and glucose and FFA mobilization was investigated in exercising rats. Apparent close relations within the two parts of the sympathoadrenal system and between factors that regulate glucose and FFA mobilization during exercise were completely disrupted by local hypothalamic infusions of adrenoceptor antagonists or anesthetic drugs. The experiments actually identified specific areas in the hypothalamus that integrate the information regarding the substrate levels in the blood with the “central command” from higher centers in the brain. Furthermore, the results of experiments with exercising intact and adrenodemedullated (Adm) rats, with and without administration of selective adrenoceptor agonists and antagonists, suggest that the activity of the sympathetic nervous system is also regulated at the level of the peripheral sympathetic nerve endings. In particular, presynaptic adrenergic regulatory mechanisms can markedly influence the outflow of NE from the sympathetic nerve endings. In conclusion, the data show that an organ-specific organization of sympathetic output during exercise may take place at different levels within the sympathetic nervous system. |
| doi_str_mv | 10.1016/0031-9384(90)90248-3 |
| format | Article |
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Apparent close relations within the two parts of the sympathoadrenal system and between factors that regulate glucose and FFA mobilization during exercise were completely disrupted by local hypothalamic infusions of adrenoceptor antagonists or anesthetic drugs. The experiments actually identified specific areas in the hypothalamus that integrate the information regarding the substrate levels in the blood with the “central command” from higher centers in the brain. Furthermore, the results of experiments with exercising intact and adrenodemedullated (Adm) rats, with and without administration of selective adrenoceptor agonists and antagonists, suggest that the activity of the sympathetic nervous system is also regulated at the level of the peripheral sympathetic nerve endings. In particular, presynaptic adrenergic regulatory mechanisms can markedly influence the outflow of NE from the sympathetic nerve endings. 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Apparent close relations within the two parts of the sympathoadrenal system and between factors that regulate glucose and FFA mobilization during exercise were completely disrupted by local hypothalamic infusions of adrenoceptor antagonists or anesthetic drugs. The experiments actually identified specific areas in the hypothalamus that integrate the information regarding the substrate levels in the blood with the “central command” from higher centers in the brain. Furthermore, the results of experiments with exercising intact and adrenodemedullated (Adm) rats, with and without administration of selective adrenoceptor agonists and antagonists, suggest that the activity of the sympathetic nervous system is also regulated at the level of the peripheral sympathetic nerve endings. In particular, presynaptic adrenergic regulatory mechanisms can markedly influence the outflow of NE from the sympathetic nerve endings. In conclusion, the data show that an organ-specific organization of sympathetic output during exercise may take place at different levels within the sympathetic nervous system.</description><subject>Adrenal Glands - innervation</subject><subject>Adrenoceptors</subject><subject>Anatomical correlates of behavior</subject><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - metabolism</subject><subject>Brain - physiology</subject><subject>Energy Metabolism - physiology</subject><subject>Epinephrine</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Free fatty acids</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glucose</subject><subject>Hypothalamus</subject><subject>Hypothalamus - physiology</subject><subject>Insulin</subject><subject>Norepinephrine</subject><subject>Presynaptic regulatory mechanisms</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Sympathetic nervous system</subject><subject>Sympathetic Nervous System - physiology</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFP5CAUx4lxo6PrN9CkF40eussDSunFxEzU3cRkL5p4I5S-KqYtFRiT-fa2zkRvLhwIvN__AT9CjoH-AgryN6Uc8oorcV7Ri4oyoXK-QxagSp4XtHzcJYtPZJ8cxPhCp8EF3yN7jKqyYMWCPC5xSMF0mRmabMTgxmect9ZPx77LfJvFdT-a9OxNE3CYSZvcm0vrjwgOGJ7WWY_J1L5zsc_ckAWT4k_yozVdxKPtekgebq7vl3_yu3-3f5dXd7kVoFIOhWyoaAwIrkDSkgGzbdFYwxHmWXNbVtPnigqYalUJta2ZAVYzCSgl8kNytuk7Bv-6wph076LFrjMD-lXUinLGQMr_glBMSgQVEyg2oA0-xoCtHoPrTVhroHo2r2etetaqK6o_zGs-xU62_Vd1j81naKt6qp9u6yZa07XBDNbFr95VKUvB5-svNxxO1t4cBh2tw8Fi4wLapBvvvn_IO4ACnyA</recordid><startdate>19901201</startdate><enddate>19901201</enddate><creator>Scheurink, Anton J.W.</creator><creator>Steffens, Anton B.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19901201</creationdate><title>Central and peripheral control of sympathoadrenal activity and energy metabolism in rats</title><author>Scheurink, Anton J.W. ; Steffens, Anton B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c418t-156d04da14381607212cf5dca3e1e1e1b3c7990259128f871bcb2a12b261e66e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adrenal Glands - innervation</topic><topic>Adrenoceptors</topic><topic>Anatomical correlates of behavior</topic><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - metabolism</topic><topic>Brain - physiology</topic><topic>Energy Metabolism - physiology</topic><topic>Epinephrine</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Free fatty acids</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glucose</topic><topic>Hypothalamus</topic><topic>Hypothalamus - physiology</topic><topic>Insulin</topic><topic>Norepinephrine</topic><topic>Presynaptic regulatory mechanisms</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Sympathetic nervous system</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scheurink, Anton J.W.</creatorcontrib><creatorcontrib>Steffens, Anton B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scheurink, Anton J.W.</au><au>Steffens, Anton B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central and peripheral control of sympathoadrenal activity and energy metabolism in rats</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1990-12-01</date><risdate>1990</risdate><volume>48</volume><issue>6</issue><spage>909</spage><epage>920</epage><pages>909-920</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>The role of adrenoceptors in the hypothalamus and the peripheral sympathetic nervous system in the regulation of sympathoadrenal activity and glucose and FFA mobilization was investigated in exercising rats. Apparent close relations within the two parts of the sympathoadrenal system and between factors that regulate glucose and FFA mobilization during exercise were completely disrupted by local hypothalamic infusions of adrenoceptor antagonists or anesthetic drugs. The experiments actually identified specific areas in the hypothalamus that integrate the information regarding the substrate levels in the blood with the “central command” from higher centers in the brain. Furthermore, the results of experiments with exercising intact and adrenodemedullated (Adm) rats, with and without administration of selective adrenoceptor agonists and antagonists, suggest that the activity of the sympathetic nervous system is also regulated at the level of the peripheral sympathetic nerve endings. In particular, presynaptic adrenergic regulatory mechanisms can markedly influence the outflow of NE from the sympathetic nerve endings. In conclusion, the data show that an organ-specific organization of sympathetic output during exercise may take place at different levels within the sympathetic nervous system.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2087525</pmid><doi>10.1016/0031-9384(90)90248-3</doi><tpages>12</tpages></addata></record> |
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| ispartof | Physiology & behavior, 1990-12, Vol.48 (6), p.909-920 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adrenal Glands - innervation Adrenoceptors Anatomical correlates of behavior Animals Behavioral psychophysiology Biological and medical sciences Blood Glucose - metabolism Brain - physiology Energy Metabolism - physiology Epinephrine Fatty Acids, Nonesterified - metabolism Free fatty acids Fundamental and applied biological sciences. Psychology Glucose Hypothalamus Hypothalamus - physiology Insulin Norepinephrine Presynaptic regulatory mechanisms Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Sympathetic nervous system Sympathetic Nervous System - physiology |
| title | Central and peripheral control of sympathoadrenal activity and energy metabolism in rats |
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