Gastric Acidity-Dependent Bioavailability of Commercial Sustained Release Preparations of Indomethacin, Evaluated by Gastric Acidity-Controlled Beagle Dogs

The relationship between gastric acidity and the bioavailability of two kinds of sustained-release indomethacin (IM) formulations was investigated in gastric acidity-controlled beagle dogs, and compared with that of rapid-release IM formulations.All test dosage forms were more rapidly dissolved in s...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1990/11/25, Vol.38(11), pp.3112-3115
Hauptverfasser:	YAMADA, Ichimaro, GODA, Tomoko, KAWATA, Miwako, SHIOTUKI, Takako, OGAWA, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beagle dog bioavailability Biological and medical sciences Biological Availability Bones, joints and connective tissue. Antiinflammatory agents Capsules Delayed-Action Preparations dissolution behavior Dogs Gastric Acid - metabolism Gastric Acid - physiology gastric acidity effect indomethacin Indomethacin - administration & dosage Indomethacin - pharmacokinetics Male Medical sciences Pharmacology. Drug treatments rapid-release formulation sustained-release formulation
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