Association between Corneal Allograft Reactions and HLA Compatibility
The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reacti...
Gespeichert in:
| Veröffentlicht in: | Ophthalmology (Rochester, Minn.) Minn.), 1990-12, Vol.97 (12), p.1689-1698 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1698 |
|---|---|
| container_issue | 12 |
| container_start_page | 1689 |
| container_title | Ophthalmology (Rochester, Minn.) |
| container_volume | 97 |
| creator | Boisjoly, Hélène M. Roy, Raynald Bernard, Paul-Marie Dubé, Ide Laughrea, Patricia A. Bazin, Richard |
| description | The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reactions and failures. Most of the recipients under observation (91 %) were well matched for HLA-DR. Of 438 recipients, 158 (36%) completed a 3-year followup. Three factors were associated with endothelial allograft reactions: 2 to 4+ corneal vascularization (relative risk, 2.2; P = 0.0006), two mismatched antigens at either the HLA-A or HLA-B locus (relative risk, 2.1; P = 0.0009), and recipient wound size of 8 mm or greater (relative risk, 1.5; P = 0.05). Unexpectedly, a strong association between endothelial allograft reactions and HLA-A or HLA-B incompatibility was found in low-risk recipients defined as unvascularized recipients of a small graft (relative risk, 3.2; P = 0.004). A larger sample size is required to determine if HLA matching offers a solution for recipients with corneal vascularization. |
| doi_str_mv | 10.1016/S0161-6420(90)32360-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80315778</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0161642090323606</els_id><sourcerecordid>80315778</sourcerecordid><originalsourceid>FETCH-LOGICAL-c390t-6dbaf811344d2db09e648ed1f6878e30b85bdc605c8bf716d2da48ba4c51111a3</originalsourceid><addsrcrecordid>eNqFkE1LAzEQhoMoWqs_QdiLoofVSZPNZk9SilqhIPhxDvmYlch2tyZbpf_e1JZ6NIfJYZ53ZngIOaNwTYGKm5dUaC74CC4ruGIjJiAXe2RAC17lvKRsnwx2yBE5jvEDAIRg_JAcjkCWDGBA7sYxdtbr3ndtZrD_RmyzSRda1E02bpruPei6z55R2zUSM926bDobJ2a-SCnjG9-vTshBrZuIp9t_SN7u714n03z29PA4Gc9yyyroc-GMriWljHM3cgYqFFyio7WQpUQGRhbGWQGFlaYuqUiQ5tJobguanmZDcrGZuwjd5xJjr-Y-Wmwa3WK3jEoCo0VZygQWG9CGLsaAtVoEP9dhpSiotT71q0-t3agK1K8-JVLubLtgaebodqmtr9Q_3_Z1tLqpg26tj3_DK1bIqqwSd7vhMNn48hhUtB5bi84HtL1ynf_nkh_w14uL</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>80315778</pqid></control><display><type>article</type><title>Association between Corneal Allograft Reactions and HLA Compatibility</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Boisjoly, Hélène M. ; Roy, Raynald ; Bernard, Paul-Marie ; Dubé, Ide ; Laughrea, Patricia A. ; Bazin, Richard</creator><creatorcontrib>Boisjoly, Hélène M. ; Roy, Raynald ; Bernard, Paul-Marie ; Dubé, Ide ; Laughrea, Patricia A. ; Bazin, Richard</creatorcontrib><description>The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reactions and failures. Most of the recipients under observation (91 %) were well matched for HLA-DR. Of 438 recipients, 158 (36%) completed a 3-year followup. Three factors were associated with endothelial allograft reactions: 2 to 4+ corneal vascularization (relative risk, 2.2; P = 0.0006), two mismatched antigens at either the HLA-A or HLA-B locus (relative risk, 2.1; P = 0.0009), and recipient wound size of 8 mm or greater (relative risk, 1.5; P = 0.05). Unexpectedly, a strong association between endothelial allograft reactions and HLA-A or HLA-B incompatibility was found in low-risk recipients defined as unvascularized recipients of a small graft (relative risk, 3.2; P = 0.004). A larger sample size is required to determine if HLA matching offers a solution for recipients with corneal vascularization.</description><identifier>ISSN: 0161-6420</identifier><identifier>EISSN: 1549-4713</identifier><identifier>DOI: 10.1016/S0161-6420(90)32360-6</identifier><identifier>PMID: 2087300</identifier><identifier>CODEN: OPHTDG</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; Child ; Child, Preschool ; Clinical Protocols ; Data Interpretation, Statistical ; Endothelium, Corneal - immunology ; Female ; Follow-Up Studies ; Graft Survival - immunology ; Histocompatibility - immunology ; Histocompatibility Testing ; HLA-A Antigens - immunology ; HLA-B Antigens - immunology ; HLA-DR Antigens - immunology ; Humans ; Keratoplasty, Penetrating - immunology ; Male ; Medical sciences ; Middle Aged ; Risk Factors ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Surgery of the eye and orbit ; Transplantation, Homologous</subject><ispartof>Ophthalmology (Rochester, Minn.), 1990-12, Vol.97 (12), p.1689-1698</ispartof><rights>1990 American Academy of Ophthalmology, Inc</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-6dbaf811344d2db09e648ed1f6878e30b85bdc605c8bf716d2da48ba4c51111a3</citedby><cites>FETCH-LOGICAL-c390t-6dbaf811344d2db09e648ed1f6878e30b85bdc605c8bf716d2da48ba4c51111a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0161-6420(90)32360-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19358979$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2087300$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boisjoly, Hélène M.</creatorcontrib><creatorcontrib>Roy, Raynald</creatorcontrib><creatorcontrib>Bernard, Paul-Marie</creatorcontrib><creatorcontrib>Dubé, Ide</creatorcontrib><creatorcontrib>Laughrea, Patricia A.</creatorcontrib><creatorcontrib>Bazin, Richard</creatorcontrib><title>Association between Corneal Allograft Reactions and HLA Compatibility</title><title>Ophthalmology (Rochester, Minn.)</title><addtitle>Ophthalmology</addtitle><description>The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reactions and failures. Most of the recipients under observation (91 %) were well matched for HLA-DR. Of 438 recipients, 158 (36%) completed a 3-year followup. Three factors were associated with endothelial allograft reactions: 2 to 4+ corneal vascularization (relative risk, 2.2; P = 0.0006), two mismatched antigens at either the HLA-A or HLA-B locus (relative risk, 2.1; P = 0.0009), and recipient wound size of 8 mm or greater (relative risk, 1.5; P = 0.05). Unexpectedly, a strong association between endothelial allograft reactions and HLA-A or HLA-B incompatibility was found in low-risk recipients defined as unvascularized recipients of a small graft (relative risk, 3.2; P = 0.004). A larger sample size is required to determine if HLA matching offers a solution for recipients with corneal vascularization.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Protocols</subject><subject>Data Interpretation, Statistical</subject><subject>Endothelium, Corneal - immunology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Graft Survival - immunology</subject><subject>Histocompatibility - immunology</subject><subject>Histocompatibility Testing</subject><subject>HLA-A Antigens - immunology</subject><subject>HLA-B Antigens - immunology</subject><subject>HLA-DR Antigens - immunology</subject><subject>Humans</subject><subject>Keratoplasty, Penetrating - immunology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Surgery of the eye and orbit</subject><subject>Transplantation, Homologous</subject><issn>0161-6420</issn><issn>1549-4713</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqs_QdiLoofVSZPNZk9SilqhIPhxDvmYlch2tyZbpf_e1JZ6NIfJYZ53ZngIOaNwTYGKm5dUaC74CC4ruGIjJiAXe2RAC17lvKRsnwx2yBE5jvEDAIRg_JAcjkCWDGBA7sYxdtbr3ndtZrD_RmyzSRda1E02bpruPei6z55R2zUSM926bDobJ2a-SCnjG9-vTshBrZuIp9t_SN7u714n03z29PA4Gc9yyyroc-GMriWljHM3cgYqFFyio7WQpUQGRhbGWQGFlaYuqUiQ5tJobguanmZDcrGZuwjd5xJjr-Y-Wmwa3WK3jEoCo0VZygQWG9CGLsaAtVoEP9dhpSiotT71q0-t3agK1K8-JVLubLtgaebodqmtr9Q_3_Z1tLqpg26tj3_DK1bIqqwSd7vhMNn48hhUtB5bi84HtL1ynf_nkh_w14uL</recordid><startdate>19901201</startdate><enddate>19901201</enddate><creator>Boisjoly, Hélène M.</creator><creator>Roy, Raynald</creator><creator>Bernard, Paul-Marie</creator><creator>Dubé, Ide</creator><creator>Laughrea, Patricia A.</creator><creator>Bazin, Richard</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19901201</creationdate><title>Association between Corneal Allograft Reactions and HLA Compatibility</title><author>Boisjoly, Hélène M. ; Roy, Raynald ; Bernard, Paul-Marie ; Dubé, Ide ; Laughrea, Patricia A. ; Bazin, Richard</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-6dbaf811344d2db09e648ed1f6878e30b85bdc605c8bf716d2da48ba4c51111a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Protocols</topic><topic>Data Interpretation, Statistical</topic><topic>Endothelium, Corneal - immunology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Graft Survival - immunology</topic><topic>Histocompatibility - immunology</topic><topic>Histocompatibility Testing</topic><topic>HLA-A Antigens - immunology</topic><topic>HLA-B Antigens - immunology</topic><topic>HLA-DR Antigens - immunology</topic><topic>Humans</topic><topic>Keratoplasty, Penetrating - immunology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Surgery of the eye and orbit</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boisjoly, Hélène M.</creatorcontrib><creatorcontrib>Roy, Raynald</creatorcontrib><creatorcontrib>Bernard, Paul-Marie</creatorcontrib><creatorcontrib>Dubé, Ide</creatorcontrib><creatorcontrib>Laughrea, Patricia A.</creatorcontrib><creatorcontrib>Bazin, Richard</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Ophthalmology (Rochester, Minn.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boisjoly, Hélène M.</au><au>Roy, Raynald</au><au>Bernard, Paul-Marie</au><au>Dubé, Ide</au><au>Laughrea, Patricia A.</au><au>Bazin, Richard</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between Corneal Allograft Reactions and HLA Compatibility</atitle><jtitle>Ophthalmology (Rochester, Minn.)</jtitle><addtitle>Ophthalmology</addtitle><date>1990-12-01</date><risdate>1990</risdate><volume>97</volume><issue>12</issue><spage>1689</spage><epage>1698</epage><pages>1689-1698</pages><issn>0161-6420</issn><eissn>1549-4713</eissn><coden>OPHTDG</coden><abstract>The purpose of this follow-up study is to measure the association between corneal allograft reactions and donor-recipient HLA-A and HLA-B compatibility. Four hundred thirty-eight consecutive adult recipients of corneal grafts with known donor-recipient HLA matching were observed for allograft reactions and failures. Most of the recipients under observation (91 %) were well matched for HLA-DR. Of 438 recipients, 158 (36%) completed a 3-year followup. Three factors were associated with endothelial allograft reactions: 2 to 4+ corneal vascularization (relative risk, 2.2; P = 0.0006), two mismatched antigens at either the HLA-A or HLA-B locus (relative risk, 2.1; P = 0.0009), and recipient wound size of 8 mm or greater (relative risk, 1.5; P = 0.05). Unexpectedly, a strong association between endothelial allograft reactions and HLA-A or HLA-B incompatibility was found in low-risk recipients defined as unvascularized recipients of a small graft (relative risk, 3.2; P = 0.004). A larger sample size is required to determine if HLA matching offers a solution for recipients with corneal vascularization.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2087300</pmid><doi>10.1016/S0161-6420(90)32360-6</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0161-6420 |
| ispartof | Ophthalmology (Rochester, Minn.), 1990-12, Vol.97 (12), p.1689-1698 |
| issn | 0161-6420 1549-4713 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80315778 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Child Child, Preschool Clinical Protocols Data Interpretation, Statistical Endothelium, Corneal - immunology Female Follow-Up Studies Graft Survival - immunology Histocompatibility - immunology Histocompatibility Testing HLA-A Antigens - immunology HLA-B Antigens - immunology HLA-DR Antigens - immunology Humans Keratoplasty, Penetrating - immunology Male Medical sciences Middle Aged Risk Factors Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the eye and orbit Transplantation, Homologous |
| title | Association between Corneal Allograft Reactions and HLA Compatibility |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T16%3A37%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20Corneal%20Allograft%20Reactions%20and%20HLA%20Compatibility&rft.jtitle=Ophthalmology%20(Rochester,%20Minn.)&rft.au=Boisjoly,%20H%C3%A9l%C3%A8ne%20M.&rft.date=1990-12-01&rft.volume=97&rft.issue=12&rft.spage=1689&rft.epage=1698&rft.pages=1689-1698&rft.issn=0161-6420&rft.eissn=1549-4713&rft.coden=OPHTDG&rft_id=info:doi/10.1016/S0161-6420(90)32360-6&rft_dat=%3Cproquest_cross%3E80315778%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=80315778&rft_id=info:pmid/2087300&rft_els_id=S0161642090323606&rfr_iscdi=true |