Changes in alpha-globin gene expression in mice of two alpha-globin haplotypes during development
Adult alpha-globin in mice is synthesized in large amounts during development, first in the primitive, nucleated erythrocytes of yolk sac origin and later in the definitive, nonnucleated erythrocytes that differentiate in the fetal liver, spleen, and bone marrow. Isoelectric focusing analysis of hem...
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| Veröffentlicht in: | Biochemical genetics 1990-10, Vol.28 (9-10), p.445-457 |
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| creator | D'SURNEY, S. J POPP, R. A |
| description | Adult alpha-globin in mice is synthesized in large amounts during development, first in the primitive, nucleated erythrocytes of yolk sac origin and later in the definitive, nonnucleated erythrocytes that differentiate in the fetal liver, spleen, and bone marrow. Isoelectric focusing analysis of hemoglobins of mice with the Hbag2 and Hbac haplotypes shows that the ratios of alpha chain 1 to chain 5m and alpha chain 1 to chain 4 in adult hemoglobins from Hbag2 and Hbac mice, respectively, change between day 11.5 and day 16.5 of gestation in nucleated red cells, while no change occurs in nonnucleated red cells. The percentage ratios of the two different alpha-globin chains are different in Hbag2 and Hbac mice for EII, EIII, and adult hemoglobin. In nucleated red cells of yolk sac origin, differences and changes in alpha-globin ratios are a composite of changing globin gene transcription and posttranslational competitive affinities among globins to form embryonic and adult hemoglobin tetramers. |
| doi_str_mv | 10.1007/BF00554373 |
| format | Article |
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J ; POPP, R. A</creator><creatorcontrib>D'SURNEY, S. J ; POPP, R. A</creatorcontrib><description>Adult alpha-globin in mice is synthesized in large amounts during development, first in the primitive, nucleated erythrocytes of yolk sac origin and later in the definitive, nonnucleated erythrocytes that differentiate in the fetal liver, spleen, and bone marrow. Isoelectric focusing analysis of hemoglobins of mice with the Hbag2 and Hbac haplotypes shows that the ratios of alpha chain 1 to chain 5m and alpha chain 1 to chain 4 in adult hemoglobins from Hbag2 and Hbac mice, respectively, change between day 11.5 and day 16.5 of gestation in nucleated red cells, while no change occurs in nonnucleated red cells. The percentage ratios of the two different alpha-globin chains are different in Hbag2 and Hbac mice for EII, EIII, and adult hemoglobin. In nucleated red cells of yolk sac origin, differences and changes in alpha-globin ratios are a composite of changing globin gene transcription and posttranslational competitive affinities among globins to form embryonic and adult hemoglobin tetramers.</description><identifier>ISSN: 0006-2928</identifier><identifier>EISSN: 1573-4927</identifier><identifier>DOI: 10.1007/BF00554373</identifier><identifier>PMID: 1707618</identifier><identifier>CODEN: BIGEBA</identifier><language>eng</language><publisher>New York, NY: Plenum Press</publisher><subject>Animals ; Biological and medical sciences ; Fetal Hemoglobin - genetics ; Fetal Hemoglobin - isolation & purification ; Fundamental and applied biological sciences. Psychology ; Gene Expression ; Globins - genetics ; Globins - isolation & purification ; Haplotypes ; Isoelectric Focusing ; Mice ; Molecular and cellular biology ; Molecular genetics</subject><ispartof>Biochemical genetics, 1990-10, Vol.28 (9-10), p.445-457</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c227t-9f01af274d86b99dc35a88c1407d426290512f15ce066afecf47446316d49ad13</citedby><cites>FETCH-LOGICAL-c227t-9f01af274d86b99dc35a88c1407d426290512f15ce066afecf47446316d49ad13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19385215$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1707618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>D'SURNEY, S. J</creatorcontrib><creatorcontrib>POPP, R. A</creatorcontrib><title>Changes in alpha-globin gene expression in mice of two alpha-globin haplotypes during development</title><title>Biochemical genetics</title><addtitle>Biochem Genet</addtitle><description>Adult alpha-globin in mice is synthesized in large amounts during development, first in the primitive, nucleated erythrocytes of yolk sac origin and later in the definitive, nonnucleated erythrocytes that differentiate in the fetal liver, spleen, and bone marrow. Isoelectric focusing analysis of hemoglobins of mice with the Hbag2 and Hbac haplotypes shows that the ratios of alpha chain 1 to chain 5m and alpha chain 1 to chain 4 in adult hemoglobins from Hbag2 and Hbac mice, respectively, change between day 11.5 and day 16.5 of gestation in nucleated red cells, while no change occurs in nonnucleated red cells. The percentage ratios of the two different alpha-globin chains are different in Hbag2 and Hbac mice for EII, EIII, and adult hemoglobin. In nucleated red cells of yolk sac origin, differences and changes in alpha-globin ratios are a composite of changing globin gene transcription and posttranslational competitive affinities among globins to form embryonic and adult hemoglobin tetramers.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fetal Hemoglobin - genetics</subject><subject>Fetal Hemoglobin - isolation & purification</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression</subject><subject>Globins - genetics</subject><subject>Globins - isolation & purification</subject><subject>Haplotypes</subject><subject>Isoelectric Focusing</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Molecular genetics</subject><issn>0006-2928</issn><issn>1573-4927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AURQdRaq1u3AvZ6EKIvvnKZJZarAoFN7oO08mbNJJkYiZR--9NaaG4ulzu4S4OIZcU7iiAun9cAEgpuOJHZEql4rHQTB2TKQAkMdMsPSVnIXyOVYMQEzKhClRC0ykx87VpCgxR2USmatcmLiq_GkuBDUb423YYQumb7V6XFiPvov7H_2fXpq18v2nHm3zoyqaIcvzGyrc1Nv05OXGmCnixzxn5WDy9z1_i5dvz6_xhGVvGVB9rB9Q4pkSeJiutc8ulSVNLBahcsIRpkJQ5Ki1CkhiH1gklRMJpkgttcspn5Gb323b-a8DQZ3UZLFaVadAPIUuBU04ZjODtDrSdD6FDl7VdWZtuk1HItj6zg88Rvtq_Dqsa8wO6Ezju1_vdBGsq15nGluGAaZ5KRiX_A0C7fHw</recordid><startdate>199010</startdate><enddate>199010</enddate><creator>D'SURNEY, S. 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Psychology</topic><topic>Gene Expression</topic><topic>Globins - genetics</topic><topic>Globins - isolation & purification</topic><topic>Haplotypes</topic><topic>Isoelectric Focusing</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Molecular genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>D'SURNEY, S. J</creatorcontrib><creatorcontrib>POPP, R. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>D'SURNEY, S. J</au><au>POPP, R. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in alpha-globin gene expression in mice of two alpha-globin haplotypes during development</atitle><jtitle>Biochemical genetics</jtitle><addtitle>Biochem Genet</addtitle><date>1990-10</date><risdate>1990</risdate><volume>28</volume><issue>9-10</issue><spage>445</spage><epage>457</epage><pages>445-457</pages><issn>0006-2928</issn><eissn>1573-4927</eissn><coden>BIGEBA</coden><abstract>Adult alpha-globin in mice is synthesized in large amounts during development, first in the primitive, nucleated erythrocytes of yolk sac origin and later in the definitive, nonnucleated erythrocytes that differentiate in the fetal liver, spleen, and bone marrow. Isoelectric focusing analysis of hemoglobins of mice with the Hbag2 and Hbac haplotypes shows that the ratios of alpha chain 1 to chain 5m and alpha chain 1 to chain 4 in adult hemoglobins from Hbag2 and Hbac mice, respectively, change between day 11.5 and day 16.5 of gestation in nucleated red cells, while no change occurs in nonnucleated red cells. The percentage ratios of the two different alpha-globin chains are different in Hbag2 and Hbac mice for EII, EIII, and adult hemoglobin. In nucleated red cells of yolk sac origin, differences and changes in alpha-globin ratios are a composite of changing globin gene transcription and posttranslational competitive affinities among globins to form embryonic and adult hemoglobin tetramers.</abstract><cop>New York, NY</cop><pub>Plenum Press</pub><pmid>1707618</pmid><doi>10.1007/BF00554373</doi><tpages>13</tpages></addata></record> |
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| ispartof | Biochemical genetics, 1990-10, Vol.28 (9-10), p.445-457 |
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| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Biological and medical sciences Fetal Hemoglobin - genetics Fetal Hemoglobin - isolation & purification Fundamental and applied biological sciences. Psychology Gene Expression Globins - genetics Globins - isolation & purification Haplotypes Isoelectric Focusing Mice Molecular and cellular biology Molecular genetics |
| title | Changes in alpha-globin gene expression in mice of two alpha-globin haplotypes during development |
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