Long-term potentiation in rat hippocampus is inhibited by low concentrations of ethanol
Acute ethanol ingestion impairs memory in humans at concentrations associated with mild intoxication. A possible neurophysiological correlate of this effect is the suppression by ethanol of long-term potentiation (LTP), a persistent increase in synaptic efficiency which has been proposed as a substr...
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| Veröffentlicht in: | Brain research 1990-12, Vol.537 (1), p.203-208 |
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| creator | Blitzer, Robert D. Gil, Orlando Landau, Emmanuel M. |
| description | Acute ethanol ingestion impairs memory in humans at concentrations associated with mild intoxication. A possible neurophysiological correlate of this effect is the suppression by ethanol of long-term potentiation (LTP), a persistent increase in synaptic efficiency which has been proposed as a substrate for memory. However, in previous studies ethanol has been shown to impair LTP only at very high concentrations, near the lethal level in humans. We now report that ethanol can significantly reduce LTP in rat hippocampus at concentrations as low as 5 mM, a level attainable following ingestion of a single alcoholic drink. We also demonstrate that the potency of ethanol in depressing LTP correlates well with its potency in inhibiting the response to
N-methyl-
d-aspartate, an agonist at the glutamate receptors implicated in LTP induction. The influence of low ethanol concentrations on LTP may contribute to the memory impairment associated with its used in humans. |
| doi_str_mv | 10.1016/0006-8993(90)90359-J |
| format | Article |
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N-methyl-
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N-methyl-
d-aspartate, an agonist at the glutamate receptors implicated in LTP induction. The influence of low ethanol concentrations on LTP may contribute to the memory impairment associated with its used in humans.</description><subject>Alcoholism and acute alcohol poisoning</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Electric Stimulation</subject><subject>Ethanol</subject><subject>Ethanol - pharmacology</subject><subject>Evoked Potentials - drug effects</subject><subject>Female</subject><subject>gamma-Aminobutyric Acid - pharmacology</subject><subject>Glutamate</subject><subject>Hippocampus</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - physiology</subject><subject>In Vitro Techniques</subject><subject>Long-term potentiation</subject><subject>Medical sciences</subject><subject>Membranes - physiology</subject><subject>Microelectrodes</subject><subject>N-methyl- d-aspartate</subject><subject>N-Methylaspartate - physiology</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, N-Methyl-D-Aspartate - drug effects</subject><subject>Synapses - drug effects</subject><subject>Synaptic plasticity</subject><subject>Toxicology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM2KFDEURoMoY8_oGyhko4yL0pukkqpsBmTwb2hwo7gMqdQtO1KVlElambc3Pd2MO4WQEO75Pi6HkGcMXjNg6g0AqKbXWlxqeKVBSN3cPCAb1ne8UbyFh2Rzjzwm5zn_qF8hNJyRM84kdJ3ckG_bGL43BdNC11gwFG-Lj4H6QJMtdOfXNTq7rPtMfT1h5wdfcKTDLZ3jb-picDWU7kKZxoli2dkQ5yfk0WTnjE9P7wX5-v7dl-uPzfbzh0_Xb7eNk0KWBhVOnFndWdkK27N698hRCFRSiNFNGroJYAAlQLm2A4HIXT8CyHZQqhMX5OWxd03x5x5zMYvPDufZBoz7bHoQDKAT_wWZ7FumBK9gewRdijknnMya_GLTrWFgDuLNwao5WDUazJ14c1Njz0_9-2HB8T50Ml3nL05zm52dp2SD8_lvt5act_yw59WRw2rtl8dksvNYLY8-oStmjP7fi_wBmC2euQ</recordid><startdate>19901224</startdate><enddate>19901224</enddate><creator>Blitzer, Robert D.</creator><creator>Gil, Orlando</creator><creator>Landau, Emmanuel M.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19901224</creationdate><title>Long-term potentiation in rat hippocampus is inhibited by low concentrations of ethanol</title><author>Blitzer, Robert D. ; Gil, Orlando ; Landau, Emmanuel M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c535t-e6ef21a97a543a815438e2e33e6533dcf907f00b06306c4703ee2c8d0054b6673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Alcoholism and acute alcohol poisoning</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Electric Stimulation</topic><topic>Ethanol</topic><topic>Ethanol - pharmacology</topic><topic>Evoked Potentials - drug effects</topic><topic>Female</topic><topic>gamma-Aminobutyric Acid - pharmacology</topic><topic>Glutamate</topic><topic>Hippocampus</topic><topic>Hippocampus - drug effects</topic><topic>Hippocampus - physiology</topic><topic>In Vitro Techniques</topic><topic>Long-term potentiation</topic><topic>Medical sciences</topic><topic>Membranes - physiology</topic><topic>Microelectrodes</topic><topic>N-methyl- d-aspartate</topic><topic>N-Methylaspartate - physiology</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, N-Methyl-D-Aspartate - drug effects</topic><topic>Synapses - drug effects</topic><topic>Synaptic plasticity</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blitzer, Robert D.</creatorcontrib><creatorcontrib>Gil, Orlando</creatorcontrib><creatorcontrib>Landau, Emmanuel M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blitzer, Robert D.</au><au>Gil, Orlando</au><au>Landau, Emmanuel M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term potentiation in rat hippocampus is inhibited by low concentrations of ethanol</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1990-12-24</date><risdate>1990</risdate><volume>537</volume><issue>1</issue><spage>203</spage><epage>208</epage><pages>203-208</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Acute ethanol ingestion impairs memory in humans at concentrations associated with mild intoxication. 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N-methyl-
d-aspartate, an agonist at the glutamate receptors implicated in LTP induction. The influence of low ethanol concentrations on LTP may contribute to the memory impairment associated with its used in humans.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2150775</pmid><doi>10.1016/0006-8993(90)90359-J</doi><tpages>6</tpages></addata></record> |
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| ispartof | Brain research, 1990-12, Vol.537 (1), p.203-208 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Alcoholism and acute alcohol poisoning Animals Biological and medical sciences Electric Stimulation Ethanol Ethanol - pharmacology Evoked Potentials - drug effects Female gamma-Aminobutyric Acid - pharmacology Glutamate Hippocampus Hippocampus - drug effects Hippocampus - physiology In Vitro Techniques Long-term potentiation Medical sciences Membranes - physiology Microelectrodes N-methyl- d-aspartate N-Methylaspartate - physiology Rat Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate - drug effects Synapses - drug effects Synaptic plasticity Toxicology |
| title | Long-term potentiation in rat hippocampus is inhibited by low concentrations of ethanol |
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