Flavonoids Inhibit the Expression of Heat Shock Proteins
Cells exposed to several forms of stress, such as heat shock, transiently synthesize a group of proteins called heat shock proteins (hsps). Although many stressors other than heat shock are known to induce hsps, inhibitors of hsp expression have never been reported. Here we show that quercetiri and...
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| Veröffentlicht in: | Cell Structure and Function 1990, Vol.15(6), pp.393-401 |
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| container_title | Cell Structure and Function |
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| creator | Hosokawa, Nobuko Hirayoshi, Kazunori Nakai, Akira Hosokawa, Ydhei Marui, Nobuyuki Yoshida, Mitsunori Sakai, Toshiyuki Nishino, Hoyoku Aoike, Akira Kawai, Keiichi Nagata, Kazuhiro |
| description | Cells exposed to several forms of stress, such as heat shock, transiently synthesize a group of proteins called heat shock proteins (hsps). Although many stressors other than heat shock are known to induce hsps, inhibitors of hsp expression have never been reported. Here we show that quercetiri and several other flavonoids inhibit the synthesis of hsps induced by heat shock in two human cell lines, Hela cells and COLO320 DM cells. Quercetin inhibited the induction of hsp70 at the level of mRNA accumulation. This is the first report to describe the inhibition of hsp expression by reagents. |
| doi_str_mv | 10.1247/csf.15.393 |
| format | Article |
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Although many stressors other than heat shock are known to induce hsps, inhibitors of hsp expression have never been reported. Here we show that quercetiri and several other flavonoids inhibit the synthesis of hsps induced by heat shock in two human cell lines, Hela cells and COLO320 DM cells. Quercetin inhibited the induction of hsp70 at the level of mRNA accumulation. This is the first report to describe the inhibition of hsp expression by reagents.</description><identifier>ISSN: 0386-7196</identifier><identifier>EISSN: 1347-3700</identifier><identifier>DOI: 10.1247/csf.15.393</identifier><identifier>PMID: 2085852</identifier><identifier>CODEN: CSFUDY</identifier><language>eng</language><publisher>Kyoto: Japan Society for Cell Biology</publisher><subject>Biological and medical sciences ; Cell physiology ; Colonic Neoplasms - pathology ; flavonoids ; Flavonoids - pharmacology ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation - drug effects ; heat shock proteins ; Heat-Shock Proteins - biosynthesis ; Heat-Shock Proteins - genetics ; HeLa Cells - drug effects ; HeLa Cells - metabolism ; Hot Temperature ; human cancer cell lines ; Humans ; Molecular and cellular biology ; Quercetin - pharmacology ; Responses to growth factors, tumor promotors, other factors ; Tumor Cells, Cultured - drug effects ; Tumor Cells, Cultured - metabolism</subject><ispartof>Cell Structure and Function, 1990, Vol.15(6), pp.393-401</ispartof><rights>Japan Society for Cell Biology</rights><rights>1991 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1990</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c603t-977d3f3f2b77108ef6da58813c41d6bc31986bcdbbb9847778003d60c0565a953</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19612772$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2085852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hosokawa, Nobuko</creatorcontrib><creatorcontrib>Hirayoshi, Kazunori</creatorcontrib><creatorcontrib>Nakai, Akira</creatorcontrib><creatorcontrib>Hosokawa, Ydhei</creatorcontrib><creatorcontrib>Marui, Nobuyuki</creatorcontrib><creatorcontrib>Yoshida, Mitsunori</creatorcontrib><creatorcontrib>Sakai, Toshiyuki</creatorcontrib><creatorcontrib>Nishino, Hoyoku</creatorcontrib><creatorcontrib>Aoike, Akira</creatorcontrib><creatorcontrib>Kawai, Keiichi</creatorcontrib><creatorcontrib>Nagata, Kazuhiro</creatorcontrib><title>Flavonoids Inhibit the Expression of Heat Shock Proteins</title><title>Cell Structure and Function</title><addtitle>Cell Struct. Funct.</addtitle><description>Cells exposed to several forms of stress, such as heat shock, transiently synthesize a group of proteins called heat shock proteins (hsps). Although many stressors other than heat shock are known to induce hsps, inhibitors of hsp expression have never been reported. Here we show that quercetiri and several other flavonoids inhibit the synthesis of hsps induced by heat shock in two human cell lines, Hela cells and COLO320 DM cells. Quercetin inhibited the induction of hsp70 at the level of mRNA accumulation. This is the first report to describe the inhibition of hsp expression by reagents.</description><subject>Biological and medical sciences</subject><subject>Cell physiology</subject><subject>Colonic Neoplasms - pathology</subject><subject>flavonoids</subject><subject>Flavonoids - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation - drug effects</subject><subject>heat shock proteins</subject><subject>Heat-Shock Proteins - biosynthesis</subject><subject>Heat-Shock Proteins - genetics</subject><subject>HeLa Cells - drug effects</subject><subject>HeLa Cells - metabolism</subject><subject>Hot Temperature</subject><subject>human cancer cell lines</subject><subject>Humans</subject><subject>Molecular and cellular biology</subject><subject>Quercetin - pharmacology</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Tumor Cells, Cultured - drug effects</subject><subject>Tumor Cells, Cultured - metabolism</subject><issn>0386-7196</issn><issn>1347-3700</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkM1LAzEUxIMoWj8u3oUF0YOw9WWz-TpKaa0gKKjnkM1mbep2U5Ot6H9vSksFL28O82PmMQidYxjiouS3JjZDTIdEkj00wKTkOeEA-2gARLCcY8mO0HGMc4CCAuOH6LAAQQUtBkhMWv3lO-_qmD10M1e5PutnNht_L4ON0fku8002tbrPXmbefGTPwffWdfEUHTS6jfZsqyfobTJ-HU3zx6f7h9HdY24YkD6XnNekIU1RcY5B2IbVmgqBiSlxzSpDsBRJ6qqqpCg55wKA1AwMUEa1pOQEXW9yl8F_rmzs1cJFY9tWd9avohJAQErBE3j5D5z7VejSbwqXVNISRCESdbOhTPAxBtuoZXALHX4UBrUeU6UxFaYqjZngi23kqlrYeodu10v-1dbX0ei2CbozLv4lSoYLztfcaMPNY6_f7Q7QoXemtetKLDld17LNSe1_7kwHZTvyC4cxkcE</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Hosokawa, Nobuko</creator><creator>Hirayoshi, Kazunori</creator><creator>Nakai, Akira</creator><creator>Hosokawa, Ydhei</creator><creator>Marui, Nobuyuki</creator><creator>Yoshida, Mitsunori</creator><creator>Sakai, Toshiyuki</creator><creator>Nishino, Hoyoku</creator><creator>Aoike, Akira</creator><creator>Kawai, Keiichi</creator><creator>Nagata, Kazuhiro</creator><general>Japan Society for Cell Biology</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Flavonoids Inhibit the Expression of Heat Shock Proteins</title><author>Hosokawa, Nobuko ; Hirayoshi, Kazunori ; Nakai, Akira ; Hosokawa, Ydhei ; Marui, Nobuyuki ; Yoshida, Mitsunori ; Sakai, Toshiyuki ; Nishino, Hoyoku ; Aoike, Akira ; Kawai, Keiichi ; Nagata, Kazuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c603t-977d3f3f2b77108ef6da58813c41d6bc31986bcdbbb9847778003d60c0565a953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Biological and medical sciences</topic><topic>Cell physiology</topic><topic>Colonic Neoplasms - pathology</topic><topic>flavonoids</topic><topic>Flavonoids - pharmacology</topic><topic>Fundamental and applied biological sciences. 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| subjects | Biological and medical sciences Cell physiology Colonic Neoplasms - pathology flavonoids Flavonoids - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Regulation - drug effects heat shock proteins Heat-Shock Proteins - biosynthesis Heat-Shock Proteins - genetics HeLa Cells - drug effects HeLa Cells - metabolism Hot Temperature human cancer cell lines Humans Molecular and cellular biology Quercetin - pharmacology Responses to growth factors, tumor promotors, other factors Tumor Cells, Cultured - drug effects Tumor Cells, Cultured - metabolism |
| title | Flavonoids Inhibit the Expression of Heat Shock Proteins |
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