Ferritin is a component of the neuritic (senile) plaque in Alzheimer dementia

A strong immunoreactivity for ferritin was observed in the neuritic (senile) plaques in Alzheimer's disease hippocampus. The ferritin accumulation was almost exclusively associated with the microglia, which appeared to have proliferated greatly. These cells were also positive for HLA-DR, a puta...

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Veröffentlicht in:	Acta neuropathologica 1990-01, Vol.81 (2), p.105-110
Hauptverfasser:	GRUNDKE-IQBAL, I, FLEMING, J, TUNG, Y.-C, LASSMANN, H, IQBAL, K, JOSHI, J. G
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alzheimer Disease - metabolism Alzheimer Disease - pathology Amyloid - metabolism Biological and medical sciences Blotting, Western Brain Chemistry Cerebral Cortex - chemistry Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Extracellular Space - metabolism Ferritins - immunology Ferritins - metabolism Free Radicals Glial Fibrillary Acidic Protein - metabolism HLA-DR Antigens - immunology Humans Immunohistochemistry Liver - chemistry Medical sciences Middle Aged Neuroglia - metabolism Neurology Neurons - metabolism Oligodendroglia - metabolism
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