Influence of septohippocampal lesion on the levels of some neurotransmitters and enzymes in the rat hippocampus

Partial deafferentation of the hippocampus was obtained by transection of unilateral partial fimbria-fornix. On the seventh postoperational day, there appeared in the lesioned hippocampus respectively a 72.5%, 45.7% and 52.2% reduction in acetylcholine content, choline acetyltransferase and cholines...

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Veröffentlicht in:	Sheng li hsüeh pao 1990-06, Vol.42 (3), p.289-294
Hauptverfasser:	Wang, J Z, Liu, C A, Hua, Z W, Bao, Z Q, Wu, W P, Wang, L X
Format:	Artikel
Sprache:	chi
Schlagworte:	Acetylcholine - metabolism Amino Acids - metabolism Animals Choline O-Acetyltransferase - metabolism Cholinergic Fibers - physiology Female Hippocampus - metabolism Hippocampus - physiology Neural Pathways - physiology Neurotransmitter Agents - metabolism Rats Rats, Inbred Strains Septal Nuclei - physiology
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description	Partial deafferentation of the hippocampus was obtained by transection of unilateral partial fimbria-fornix. On the seventh postoperational day, there appeared in the lesioned hippocampus respectively a 72.5%, 45.7% and 52.2% reduction in acetylcholine content, choline acetyltransferase and cholinesterase activity. A concomitant 16.3%, 31.1% and 30.3% reduction in noradrenaline, dopamine and serotonin content respectively was also observed, while amino acids content did not show any change. The results indicate that the cholinergic and monoaminergic afferents of the hippocampal formation in the rat reach their target regions via the fimbria-fornix.
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The results indicate that the cholinergic and monoaminergic afferents of the hippocampal formation in the rat reach their target regions via the fimbria-fornix.</description><identifier>ISSN: 0371-0874</identifier><identifier>PMID: 1982025</identifier><language>chi</language><publisher>China</publisher><subject>Acetylcholine - metabolism ; Amino Acids - metabolism ; Animals ; Choline O-Acetyltransferase - metabolism ; Cholinergic Fibers - physiology ; Female ; Hippocampus - metabolism ; Hippocampus - physiology ; Neural Pathways - physiology ; Neurotransmitter Agents - metabolism ; Rats ; Rats, Inbred Strains ; Septal Nuclei - physiology</subject><ispartof>Sheng li hsüeh pao, 1990-06, Vol.42 (3), p.289-294</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1982025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, J Z</creatorcontrib><creatorcontrib>Liu, C A</creatorcontrib><creatorcontrib>Hua, Z W</creatorcontrib><creatorcontrib>Bao, Z Q</creatorcontrib><creatorcontrib>Wu, W P</creatorcontrib><creatorcontrib>Wang, L X</creatorcontrib><title>Influence of septohippocampal lesion on the levels of some neurotransmitters and enzymes in the rat hippocampus</title><title>Sheng li hsüeh pao</title><addtitle>Sheng Li Xue Bao</addtitle><description>Partial deafferentation of the hippocampus was obtained by transection of unilateral partial fimbria-fornix. 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subjects	Acetylcholine - metabolism Amino Acids - metabolism Animals Choline O-Acetyltransferase - metabolism Cholinergic Fibers - physiology Female Hippocampus - metabolism Hippocampus - physiology Neural Pathways - physiology Neurotransmitter Agents - metabolism Rats Rats, Inbred Strains Septal Nuclei - physiology
title	Influence of septohippocampal lesion on the levels of some neurotransmitters and enzymes in the rat hippocampus
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