High versus low dose granisetron, a selective 5HT3 antagonist, for the prevention of chemotherapy-induced nausea and vomiting
Fifty six patients, with histologically confirmed cancer, who received highly emetogenic chemotherapy, were entered on a randomized double blind, low versus high dose, study of granisetron, a 5HT3 receptor antagonist. A single dose of intravenous granisetron protected the majority of patients from n...
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| Veröffentlicht in: | Investigational new drugs 1990-11, Vol.8 (4), p.407-409 |
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| creator | FALKSON, H. C FALKSON, C. I FALKSON, G |
| description | Fifty six patients, with histologically confirmed cancer, who received highly emetogenic chemotherapy, were entered on a randomized double blind, low versus high dose, study of granisetron, a 5HT3 receptor antagonist. A single dose of intravenous granisetron protected the majority of patients from nausea and vomiting, 160 micrograms/kg was more effective than 40 micrograms/kg with no more side effects. Additional doses of granisetron conferred added benefit to patients who experienced breakthrough symptoms. Granisetron at a dose range of 40-240 micrograms/kg over a 24 hour period was well tolerated with the only side effect being mild headache. |
| doi_str_mv | 10.1007/BF00198602 |
| format | Article |
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Granisetron at a dose range of 40-240 micrograms/kg over a 24 hour period was well tolerated with the only side effect being mild headache.</description><identifier>ISSN: 0167-6997</identifier><identifier>EISSN: 1573-0646</identifier><identifier>DOI: 10.1007/BF00198602</identifier><identifier>PMID: 1964678</identifier><identifier>CODEN: INNDDK</identifier><language>eng</language><publisher>Dordrecht: Kluwer</publisher><subject>Antineoplastic Agents - adverse effects ; Biological and medical sciences ; Digestive system ; Double-Blind Method ; Drugs, Investigational - administration & dosage ; Female ; Granisetron ; Humans ; Indazoles - administration & dosage ; Male ; Medical sciences ; Middle Aged ; Nausea - chemically induced ; Nausea - prevention & control ; Pharmacology. 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Granisetron at a dose range of 40-240 micrograms/kg over a 24 hour period was well tolerated with the only side effect being mild headache.</description><subject>Antineoplastic Agents - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Drugs, Investigational - administration & dosage</subject><subject>Female</subject><subject>Granisetron</subject><subject>Humans</subject><subject>Indazoles - administration & dosage</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nausea - chemically induced</subject><subject>Nausea - prevention & control</subject><subject>Pharmacology. Drug treatments</subject><subject>Random Allocation</subject><subject>Serotonin Antagonists - administration & dosage</subject><subject>Vomiting - chemically induced</subject><subject>Vomiting - prevention & control</subject><issn>0167-6997</issn><issn>1573-0646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM9v1DAQhS0EKtvChTuSL3BADYzjH0mOUFEWqRKXco4m9mTXKLEX21nUA_87QbtSexpp3vfe4WPsjYCPAqD59OUWQHStgfoZ2wjdyAqMMs_ZBoRpKtN1zUt2mfMvAJBdoy7YhehWoGk37O_W7_b8SCkvmU_xD3cxE98lDD5TSTFcc-SZJrLFH4nr7b3kGAru4gqUaz7GxMue-CHRkULxMfA4crunOa7vhIeHyge3WHI84JIJ17bjxzj74sPuFXsx4pTp9flesZ-3X-9vttXdj2_fbz7fVVaKulRy1EZrrVphnWwt2Rq0qHUNnRnbBhRIOzgnFCoaBrS6VUoNTuMwKBxQGnnF3p92Dyn-XiiXfvbZ0jRhoLjkvgUJBky7gh9OoE0x50Rjf0h-xvTQC-j_u-4fXa_w2_PqMszkHtGT3DV_d84xW5zGVar1-QmmhKobIf8B4NKHSQ</recordid><startdate>19901101</startdate><enddate>19901101</enddate><creator>FALKSON, H. 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I ; FALKSON, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c312t-3f56555481cd38cec2051252096f870403cbdd14a4ebbac58444bd5abb4aba363</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Antineoplastic Agents - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Double-Blind Method</topic><topic>Drugs, Investigational - administration & dosage</topic><topic>Female</topic><topic>Granisetron</topic><topic>Humans</topic><topic>Indazoles - administration & dosage</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nausea - chemically induced</topic><topic>Nausea - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>Random Allocation</topic><topic>Serotonin Antagonists - administration & dosage</topic><topic>Vomiting - chemically induced</topic><topic>Vomiting - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FALKSON, H. C</creatorcontrib><creatorcontrib>FALKSON, C. I</creatorcontrib><creatorcontrib>FALKSON, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Investigational new drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FALKSON, H. C</au><au>FALKSON, C. I</au><au>FALKSON, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High versus low dose granisetron, a selective 5HT3 antagonist, for the prevention of chemotherapy-induced nausea and vomiting</atitle><jtitle>Investigational new drugs</jtitle><addtitle>Invest New Drugs</addtitle><date>1990-11-01</date><risdate>1990</risdate><volume>8</volume><issue>4</issue><spage>407</spage><epage>409</epage><pages>407-409</pages><issn>0167-6997</issn><eissn>1573-0646</eissn><coden>INNDDK</coden><abstract>Fifty six patients, with histologically confirmed cancer, who received highly emetogenic chemotherapy, were entered on a randomized double blind, low versus high dose, study of granisetron, a 5HT3 receptor antagonist. A single dose of intravenous granisetron protected the majority of patients from nausea and vomiting, 160 micrograms/kg was more effective than 40 micrograms/kg with no more side effects. 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| fulltext | fulltext |
| identifier | ISSN: 0167-6997 |
| ispartof | Investigational new drugs, 1990-11, Vol.8 (4), p.407-409 |
| issn | 0167-6997 1573-0646 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80306068 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Antineoplastic Agents - adverse effects Biological and medical sciences Digestive system Double-Blind Method Drugs, Investigational - administration & dosage Female Granisetron Humans Indazoles - administration & dosage Male Medical sciences Middle Aged Nausea - chemically induced Nausea - prevention & control Pharmacology. Drug treatments Random Allocation Serotonin Antagonists - administration & dosage Vomiting - chemically induced Vomiting - prevention & control |
| title | High versus low dose granisetron, a selective 5HT3 antagonist, for the prevention of chemotherapy-induced nausea and vomiting |
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