Sexual Dimorphism of Inactive Renin in Rat Plasma
The plasma concentration of inactive renin was higher (p
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| Veröffentlicht in: | Clinical and experimental hypertension (1993) 1990, Vol.A12 (8), p.1405-1417 |
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| container_title | Clinical and experimental hypertension (1993) |
| container_volume | A12 |
| creator | Johannessen, Arne Nielsen, Arne Høj Poulsen, Knud |
| description | The plasma concentration of inactive renin was higher (p |
| doi_str_mv | 10.3109/10641969009073527 |
| format | Article |
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Our findings indicate that androgens may be involved in the regulation of the plasma concentration of inactive renin in rats, but also suggest that other factors may be of importance.</description><identifier>ISSN: 1064-1963</identifier><identifier>ISSN: 0730-0077</identifier><identifier>EISSN: 1525-6006</identifier><identifier>DOI: 10.3109/10641969009073527</identifier><identifier>PMID: 2081373</identifier><identifier>CODEN: CEHADM</identifier><language>eng</language><publisher>Basel: Informa UK Ltd</publisher><subject>andpogens ; Androgens - physiology ; Animals ; Biological and medical sciences ; Enzyme Precursors - blood ; Enzymes. Coenzymes. Vitamins. Pigments ; Female ; Flutamide - pharmacology ; Fundamental and applied biological sciences. Psychology ; inactive renin ; Male ; Metabolisms and neurohumoral controls ; Orchiectomy ; plasma ; Rats ; Rats, Inbred Strains ; renin ; Renin - blood ; Sex Characteristics ; Testis - physiology ; Testosterone - pharmacology ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Clinical and experimental hypertension (1993), 1990, Vol.A12 (8), p.1405-1417</ispartof><rights>1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-8d773fca66b0ef9facb711b0dbe5f71fd354abf85c46a39d3894b329e57e708c3</citedby><cites>FETCH-LOGICAL-c497t-8d773fca66b0ef9facb711b0dbe5f71fd354abf85c46a39d3894b329e57e708c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/10641969009073527$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/10641969009073527$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,60436,61221,61402</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19545701$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2081373$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johannessen, Arne</creatorcontrib><creatorcontrib>Nielsen, Arne Høj</creatorcontrib><creatorcontrib>Poulsen, Knud</creatorcontrib><title>Sexual Dimorphism of Inactive Renin in Rat Plasma</title><title>Clinical and experimental hypertension (1993)</title><addtitle>Clin Exp Hypertens A</addtitle><description>The plasma concentration of inactive renin was higher (p<0.002) in male (0.48 Goldblatt units (GU)/1, range 0.28-0.67 GU/1; n=20) than in female rats (0.19 GU/1, range 0.09-0.30 GU/1; n=20). This new finding indicates a sexual dimorphism of inactive plasma renin similar to that recently reported in mice and humans. Castration of male rats (n=10) decreased (p<0.01) inactive plasma renin from 0.45 GU/1 (range 0.22-0.65 GU/1) to 0.26 GU/1 (range 0.15-0.37 GU/1) over a period of seven weeks. Similarly, inactive renin decreased (p<0.01) from 0.50 GU/1 (range 0.28-0.67 GU/1) to 0.30 GU/1 (range 0.19-0.47 GU/1) during treatment with the anti-androgen flutamide (n=10). In castrated male rats (n=10), inactive plasma renin was unaffected of substitution with testosterone. In intact female rats (n=10), inactive renin increased (p<0.05) from 0.18 GU/1 (range 0.12-0.30 GU/1) to 0.27 GU/1 (range 0.15-0.40 GU/1) during testosterone treatment.
Our findings indicate that androgens may be involved in the regulation of the plasma concentration of inactive renin in rats, but also suggest that other factors may be of importance.</description><subject>andpogens</subject><subject>Androgens - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Enzyme Precursors - blood</subject><subject>Enzymes. Coenzymes. Vitamins. Pigments</subject><subject>Female</subject><subject>Flutamide - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>inactive renin</subject><subject>Male</subject><subject>Metabolisms and neurohumoral controls</subject><subject>Orchiectomy</subject><subject>plasma</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>renin</subject><subject>Renin - blood</subject><subject>Sex Characteristics</subject><subject>Testis - physiology</subject><subject>Testosterone - pharmacology</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>1064-1963</issn><issn>0730-0077</issn><issn>1525-6006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFr2zAUhcXoSNN2P2APA7-0b-6uIkuyaF9K1naBQEfaPptrWSIuspVKdrv8-2kk2xiFwgVdON85XB1CPlM4ZxTUVwqioEooAAWS8Zn8QKaUz3guAMRB2pOeJ4AdkqMYnwBoIXg5IZMZlJRJNiX03vwc0WXf2s6HzbqNXeZttuhRD-2LyVamb_sszQqH7IfD2OEJ-WjRRfNp_x6Tx5vrh_n3fHl3u5hfLXNdKDnkZSMlsxqFqMFYZVHXktIamtpwK6ltGC-wtiXXhUCmGlaqomYzZbg0EkrNjsnZLncT_PNo4lB1bdTGOeyNH2NVAgOuCpFAugN18DEGY6tNaDsM24pC9bum6k1NyfNlHz7WnWn-Ova9JP10r2PU6GzAXrfxX7DiBZdAE3e549re-tDhqw-uqQbcOh_-mNh7Z1z8Z18bdMNaYzDVkx9Dn_p95xO_AL2gk1o</recordid><startdate>1990</startdate><enddate>1990</enddate><creator>Johannessen, Arne</creator><creator>Nielsen, Arne Høj</creator><creator>Poulsen, Knud</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Dekker</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1990</creationdate><title>Sexual Dimorphism of Inactive Renin in Rat Plasma</title><author>Johannessen, Arne ; Nielsen, Arne Høj ; Poulsen, Knud</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-8d773fca66b0ef9facb711b0dbe5f71fd354abf85c46a39d3894b329e57e708c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>andpogens</topic><topic>Androgens - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Enzyme Precursors - blood</topic><topic>Enzymes. Coenzymes. Vitamins. Pigments</topic><topic>Female</topic><topic>Flutamide - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>inactive renin</topic><topic>Male</topic><topic>Metabolisms and neurohumoral controls</topic><topic>Orchiectomy</topic><topic>plasma</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>renin</topic><topic>Renin - blood</topic><topic>Sex Characteristics</topic><topic>Testis - physiology</topic><topic>Testosterone - pharmacology</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johannessen, Arne</creatorcontrib><creatorcontrib>Nielsen, Arne Høj</creatorcontrib><creatorcontrib>Poulsen, Knud</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental hypertension (1993)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johannessen, Arne</au><au>Nielsen, Arne Høj</au><au>Poulsen, Knud</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexual Dimorphism of Inactive Renin in Rat Plasma</atitle><jtitle>Clinical and experimental hypertension (1993)</jtitle><addtitle>Clin Exp Hypertens A</addtitle><date>1990</date><risdate>1990</risdate><volume>A12</volume><issue>8</issue><spage>1405</spage><epage>1417</epage><pages>1405-1417</pages><issn>1064-1963</issn><issn>0730-0077</issn><eissn>1525-6006</eissn><coden>CEHADM</coden><abstract>The plasma concentration of inactive renin was higher (p<0.002) in male (0.48 Goldblatt units (GU)/1, range 0.28-0.67 GU/1; n=20) than in female rats (0.19 GU/1, range 0.09-0.30 GU/1; n=20). This new finding indicates a sexual dimorphism of inactive plasma renin similar to that recently reported in mice and humans. Castration of male rats (n=10) decreased (p<0.01) inactive plasma renin from 0.45 GU/1 (range 0.22-0.65 GU/1) to 0.26 GU/1 (range 0.15-0.37 GU/1) over a period of seven weeks. Similarly, inactive renin decreased (p<0.01) from 0.50 GU/1 (range 0.28-0.67 GU/1) to 0.30 GU/1 (range 0.19-0.47 GU/1) during treatment with the anti-androgen flutamide (n=10). In castrated male rats (n=10), inactive plasma renin was unaffected of substitution with testosterone. In intact female rats (n=10), inactive renin increased (p<0.05) from 0.18 GU/1 (range 0.12-0.30 GU/1) to 0.27 GU/1 (range 0.15-0.40 GU/1) during testosterone treatment.
Our findings indicate that androgens may be involved in the regulation of the plasma concentration of inactive renin in rats, but also suggest that other factors may be of importance.</abstract><cop>Basel</cop><cop>Hong Kong</cop><cop>New York, NY</cop><pub>Informa UK Ltd</pub><pmid>2081373</pmid><doi>10.3109/10641969009073527</doi><tpages>13</tpages></addata></record> |
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| source | MEDLINE; Taylor & Francis:Master (3349 titles) |
| subjects | andpogens Androgens - physiology Animals Biological and medical sciences Enzyme Precursors - blood Enzymes. Coenzymes. Vitamins. Pigments Female Flutamide - pharmacology Fundamental and applied biological sciences. Psychology inactive renin Male Metabolisms and neurohumoral controls Orchiectomy plasma Rats Rats, Inbred Strains renin Renin - blood Sex Characteristics Testis - physiology Testosterone - pharmacology Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Sexual Dimorphism of Inactive Renin in Rat Plasma |
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