1, 25-Dihydroxyvitamin D Production Stimulated by Dibutyryl 3', 5'-Cyclic AMP in Normal Subjects and a Patient with Pseudohypoparathyroidism
UNAKAMI, H., FURUKAWA, Y., SOHN, H.E., YUMITA, S., MIURA, R., SASAKI, A., KOKUBUN, M., MIURA, Y., YOSHINAGA, K. and NAKANOME, C. 1, 25-Dihydroxyvitamin D Production Stimulated by Dibutyryl 3', 5'-Cyclic AMP in Normal Subjects and a Patient with Pseudohypoparathyroidism. Tohoku J. exp. Med....
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Veröffentlicht in: | The Tohoku Journal of Experimental Medicine 1982, Vol.138(4), pp.411-418 |
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Sprache: | eng |
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Zusammenfassung: | UNAKAMI, H., FURUKAWA, Y., SOHN, H.E., YUMITA, S., MIURA, R., SASAKI, A., KOKUBUN, M., MIURA, Y., YOSHINAGA, K. and NAKANOME, C. 1, 25-Dihydroxyvitamin D Production Stimulated by Dibutyryl 3', 5'-Cyclic AMP in Normal Subjects and a Patient with Pseudohypoparathyroidism. Tohoku J. exp. Med., 1982, 138 (4), 411-418-Dibutyryl 3', 5'-cyclic AMP (DBcAMP) was infused in 4 normal subjects and a patient with pseudohypoparathyroidism (PHP) to study its effect on the production of 1, 25-dihydroxyvitamin D [1, 25(OH)2D]. In normal subjects, 2.5mg/kg of DBcAMP increased plasma 1, 25(OH)2D. reaching the peak at 6hr after infusion, while, 6.0mg/kg of DBcAMP delayed the peak to 12hr. The maximal increment of plasma 1, 25(OH)2D was 19.7±2.8pg/ml (mean±S.D.) in normals with 6.0mg/kg of DBcAMP and 12.2±1.0pg/ml (mean±S.D.) with 2.5 mg/kg, respectively. There was a significant difference between the doses (p |
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ISSN: | 0040-8727 1349-3329 |
DOI: | 10.1620/tjem.138.411 |