Studies on the structure of polysaccharides from the bark of Melia azadirachta
Water-soluble polysaccharides, designated as GIa and GIb, were isolated from the bark of Melia azadirachta (Meliaceae) and their inhibiting effect on subcutaneously inoculated Sarcoma-180 was tested. GIa and GIb each gave a single peak on ultracentrifugation and gel filtration. Methylation, periodat...
Gespeichert in:
| Veröffentlicht in: | Chemical & pharmaceutical bulletin 1982/11/25, Vol.30(11), pp.4025-4030 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 4030 |
|---|---|
| container_issue | 11 |
| container_start_page | 4025 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 30 |
| creator | Fujiwara, T Takeda, T Ogihara, Y Shimizu, M Nomura, T |
| description | Water-soluble polysaccharides, designated as GIa and GIb, were isolated from the bark of Melia azadirachta (Meliaceae) and their inhibiting effect on subcutaneously inoculated Sarcoma-180 was tested. GIa and GIb each gave a single peak on ultracentrifugation and gel filtration. Methylation, periodate oxidation and 13C-NMR spectroscopic studies suggested that GIa is composed of the following repeating unit ; α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 6←1α-L-Araf. GIb is a branched arabinofucoglucan, containing a main chain of (1→4)-linked α-D-glucopyranosyl units substituted in the 6 position with side chains of α-L-arabinofuranosyl units. 3-O-substituted fucopyranose is attached to the α-(1→4) glucose units at the 4 position in the main chain. |
| doi_str_mv | 10.1248/cpb.30.4025 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_80297273</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3132113391</sourcerecordid><originalsourceid>FETCH-LOGICAL-c632t-eb2953a1c1710e607264ce0acb4f33992a1ea9ce0f6a90447c85d517422637083</originalsourceid><addsrcrecordid>eNpdkEtr3DAURkVoSSdpV1mXGgrZBE-uHrasZQlNUkibRZq1uJavM556RlNJXqS_vnJnSKAbCfQdDuIwdsZhyYVqLt2uXUpYKhDVEVtwqXRZCSHfsAUAmFLIWr5jJzGuIROg5TE71ryuGq0X7MdDmrqBYuG3RVpREVOYXJoCFb4vdn58jujcCsPQZaYPfvOPajH8moHvNA5Y4B_shoBulfA9e9vjGOnD4T5lj9dff17dlnf3N9-uvtyVrpYildQKU0nkjmsOVIMWtXIE6FrVS2mMQE5o8ktfowGltGuqruJaCVFLDY08Zed77y743xPFZDdDdDSOuCU_RduAMFpomcHP_4FrP4Vt_pvlqjJGZSnP1MWecsHHGKi3uzBsMDxbDnZubHNjK8HOjTP98eCc2g11L-what6v9_s6Jnyilx1DGtxIs4ubqpl9nB_OWfwK5OCWtln0aS_q0Vt8CkO0jw8CuMyw4aCk_Auu15bz</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1459941741</pqid></control><display><type>article</type><title>Studies on the structure of polysaccharides from the bark of Melia azadirachta</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Fujiwara, T ; Takeda, T ; Ogihara, Y ; Shimizu, M ; Nomura, T</creator><creatorcontrib>Fujiwara, T ; Takeda, T ; Ogihara, Y ; Shimizu, M ; Nomura, T</creatorcontrib><description>Water-soluble polysaccharides, designated as GIa and GIb, were isolated from the bark of Melia azadirachta (Meliaceae) and their inhibiting effect on subcutaneously inoculated Sarcoma-180 was tested. GIa and GIb each gave a single peak on ultracentrifugation and gel filtration. Methylation, periodate oxidation and 13C-NMR spectroscopic studies suggested that GIa is composed of the following repeating unit ; α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 6←1α-L-Araf. GIb is a branched arabinofucoglucan, containing a main chain of (1→4)-linked α-D-glucopyranosyl units substituted in the 6 position with side chains of α-L-arabinofuranosyl units. 3-O-substituted fucopyranose is attached to the α-(1→4) glucose units at the 4 position in the main chain.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.30.4025</identifier><identifier>PMID: 7165877</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Antineoplastic Agents, Phytogenic - analysis ; C-NMR ; Mice ; Mice, Inbred ICR ; plant biochemistry ; plant physiology ; Plant Science and Plant Products ; plants ; Plants, Medicinal - analysis ; Polysaccharides - analysis ; Polysaccharides - pharmacology</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1982/11/25, Vol.30(11), pp.4025-4030</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>Copyright Japan Science and Technology Agency 1982</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c632t-eb2953a1c1710e607264ce0acb4f33992a1ea9ce0f6a90447c85d517422637083</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1884,27929,27930</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7165877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fujiwara, T</creatorcontrib><creatorcontrib>Takeda, T</creatorcontrib><creatorcontrib>Ogihara, Y</creatorcontrib><creatorcontrib>Shimizu, M</creatorcontrib><creatorcontrib>Nomura, T</creatorcontrib><title>Studies on the structure of polysaccharides from the bark of Melia azadirachta</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem. Pharm. Bull.</addtitle><description>Water-soluble polysaccharides, designated as GIa and GIb, were isolated from the bark of Melia azadirachta (Meliaceae) and their inhibiting effect on subcutaneously inoculated Sarcoma-180 was tested. GIa and GIb each gave a single peak on ultracentrifugation and gel filtration. Methylation, periodate oxidation and 13C-NMR spectroscopic studies suggested that GIa is composed of the following repeating unit ; α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 6←1α-L-Araf. GIb is a branched arabinofucoglucan, containing a main chain of (1→4)-linked α-D-glucopyranosyl units substituted in the 6 position with side chains of α-L-arabinofuranosyl units. 3-O-substituted fucopyranose is attached to the α-(1→4) glucose units at the 4 position in the main chain.</description><subject>Animals</subject><subject>Antineoplastic Agents, Phytogenic - analysis</subject><subject>C-NMR</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>plant biochemistry</subject><subject>plant physiology</subject><subject>Plant Science and Plant Products</subject><subject>plants</subject><subject>Plants, Medicinal - analysis</subject><subject>Polysaccharides - analysis</subject><subject>Polysaccharides - pharmacology</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkEtr3DAURkVoSSdpV1mXGgrZBE-uHrasZQlNUkibRZq1uJavM556RlNJXqS_vnJnSKAbCfQdDuIwdsZhyYVqLt2uXUpYKhDVEVtwqXRZCSHfsAUAmFLIWr5jJzGuIROg5TE71ryuGq0X7MdDmrqBYuG3RVpREVOYXJoCFb4vdn58jujcCsPQZaYPfvOPajH8moHvNA5Y4B_shoBulfA9e9vjGOnD4T5lj9dff17dlnf3N9-uvtyVrpYildQKU0nkjmsOVIMWtXIE6FrVS2mMQE5o8ktfowGltGuqruJaCVFLDY08Zed77y743xPFZDdDdDSOuCU_RduAMFpomcHP_4FrP4Vt_pvlqjJGZSnP1MWecsHHGKi3uzBsMDxbDnZubHNjK8HOjTP98eCc2g11L-what6v9_s6Jnyilx1DGtxIs4ubqpl9nB_OWfwK5OCWtln0aS_q0Vt8CkO0jw8CuMyw4aCk_Auu15bz</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Fujiwara, T</creator><creator>Takeda, T</creator><creator>Ogihara, Y</creator><creator>Shimizu, M</creator><creator>Nomura, T</creator><general>The Pharmaceutical Society of Japan</general><general>Japan Science and Technology Agency</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19820101</creationdate><title>Studies on the structure of polysaccharides from the bark of Melia azadirachta</title><author>Fujiwara, T ; Takeda, T ; Ogihara, Y ; Shimizu, M ; Nomura, T</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c632t-eb2953a1c1710e607264ce0acb4f33992a1ea9ce0f6a90447c85d517422637083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Antineoplastic Agents, Phytogenic - analysis</topic><topic>C-NMR</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>plant biochemistry</topic><topic>plant physiology</topic><topic>Plant Science and Plant Products</topic><topic>plants</topic><topic>Plants, Medicinal - analysis</topic><topic>Polysaccharides - analysis</topic><topic>Polysaccharides - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fujiwara, T</creatorcontrib><creatorcontrib>Takeda, T</creatorcontrib><creatorcontrib>Ogihara, Y</creatorcontrib><creatorcontrib>Shimizu, M</creatorcontrib><creatorcontrib>Nomura, T</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fujiwara, T</au><au>Takeda, T</au><au>Ogihara, Y</au><au>Shimizu, M</au><au>Nomura, T</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on the structure of polysaccharides from the bark of Melia azadirachta</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>30</volume><issue>11</issue><spage>4025</spage><epage>4030</epage><pages>4025-4030</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>Water-soluble polysaccharides, designated as GIa and GIb, were isolated from the bark of Melia azadirachta (Meliaceae) and their inhibiting effect on subcutaneously inoculated Sarcoma-180 was tested. GIa and GIb each gave a single peak on ultracentrifugation and gel filtration. Methylation, periodate oxidation and 13C-NMR spectroscopic studies suggested that GIa is composed of the following repeating unit ; α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 1→4α-D-Glc 6←1α-L-Araf. GIb is a branched arabinofucoglucan, containing a main chain of (1→4)-linked α-D-glucopyranosyl units substituted in the 6 position with side chains of α-L-arabinofuranosyl units. 3-O-substituted fucopyranose is attached to the α-(1→4) glucose units at the 4 position in the main chain.</abstract><cop>Japan</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>7165877</pmid><doi>10.1248/cpb.30.4025</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-2363 |
| ispartof | Chemical and Pharmaceutical Bulletin, 1982/11/25, Vol.30(11), pp.4025-4030 |
| issn | 0009-2363 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80297273 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Antineoplastic Agents, Phytogenic - analysis C-NMR Mice Mice, Inbred ICR plant biochemistry plant physiology Plant Science and Plant Products plants Plants, Medicinal - analysis Polysaccharides - analysis Polysaccharides - pharmacology |
| title | Studies on the structure of polysaccharides from the bark of Melia azadirachta |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-16T02%3A36%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Studies%20on%20the%20structure%20of%20polysaccharides%20from%20the%20bark%20of%20Melia%20azadirachta&rft.jtitle=Chemical%20&%20pharmaceutical%20bulletin&rft.au=Fujiwara,%20T&rft.date=1982-01-01&rft.volume=30&rft.issue=11&rft.spage=4025&rft.epage=4030&rft.pages=4025-4030&rft.issn=0009-2363&rft.eissn=1347-5223&rft_id=info:doi/10.1248/cpb.30.4025&rft_dat=%3Cproquest_cross%3E3132113391%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1459941741&rft_id=info:pmid/7165877&rfr_iscdi=true |