Sensory nerve depletion potentiates inhibitory non-adrenergic, non-cholinergic nerves in guinea-pig airways
The effect of sensory neuropeptide depletion by systemac capsaicin pretreatment was studied both on inhibitory non-adrenergic, non-cholinergic responses elicited to electrical field stimulation and on bronchodilator responses to vasoactive intestinal peptide (the putative transmitter of these nerves...
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| Veröffentlicht in: | European journal of pharmacology 1990-08, Vol.184 (2), p.333-337 |
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| container_end_page | 337 |
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| container_title | European journal of pharmacology |
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| creator | Stretton, C.David Belvisi, Maria G. Barnes, Peter J. |
| description | The effect of sensory neuropeptide depletion by systemac capsaicin pretreatment was studied both on inhibitory non-adrenergic, non-cholinergic responses elicited to electrical field stimulation and on bronchodilator responses to vasoactive intestinal peptide (the putative transmitter of these nerves), in guinea-pig trachea. Capsaicin pretreatment enhanced the relaxation responses induced by both electrical field stimulation and vasoactive intestinal peptide, whereas these responses were not significantly increased in vehicle-pretreated or in untreated animals. The bronchodilator response to isoprenaline was unaffected by capsaicin pretreatment. Sensory neuropeptide depletion therefore augments both inhibitory non-adrenergic, non-cholinergic responses and responses to exogenous vasoactive intestinal peptide, suggesting an effect on vasoactive intestinal peptide receptors. |
| doi_str_mv | 10.1016/0014-2999(90)90628-J |
| format | Article |
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Capsaicin pretreatment enhanced the relaxation responses induced by both electrical field stimulation and vasoactive intestinal peptide, whereas these responses were not significantly increased in vehicle-pretreated or in untreated animals. The bronchodilator response to isoprenaline was unaffected by capsaicin pretreatment. Sensory neuropeptide depletion therefore augments both inhibitory non-adrenergic, non-cholinergic responses and responses to exogenous vasoactive intestinal peptide, suggesting an effect on vasoactive intestinal peptide receptors.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(90)90628-J</identifier><identifier>PMID: 2079103</identifier><identifier>CODEN: EJPHAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Air breathing ; Airway Resistance - drug effects ; Airways (guinea-pig) ; Animals ; Biological and medical sciences ; Capsaicin ; Capsaicin - pharmacology ; Electric Stimulation ; Fundamental and applied biological sciences. Psychology ; Guinea Pigs ; In Vitro Techniques ; Isoproterenol - pharmacology ; Male ; Neuropeptides - deficiency ; Non-adrenergic, non-cholinergic (NANC) responses (inhibitory) ; Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics ; Sensation - physiology ; Trachea - innervation ; Vasoactive Intestinal Peptide - pharmacology ; Vertebrates: respiratory system</subject><ispartof>European journal of pharmacology, 1990-08, Vol.184 (2), p.333-337</ispartof><rights>1990</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c359t-f5f53eda980110c4a6f532dd04cabc55020238b00d553ba1ccbf4e59636c4bbc3</citedby><cites>FETCH-LOGICAL-c359t-f5f53eda980110c4a6f532dd04cabc55020238b00d553ba1ccbf4e59636c4bbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001429999090628J$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19272898$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2079103$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Stretton, C.David</creatorcontrib><creatorcontrib>Belvisi, Maria G.</creatorcontrib><creatorcontrib>Barnes, Peter J.</creatorcontrib><title>Sensory nerve depletion potentiates inhibitory non-adrenergic, non-cholinergic nerves in guinea-pig airways</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>The effect of sensory neuropeptide depletion by systemac capsaicin pretreatment was studied both on inhibitory non-adrenergic, non-cholinergic responses elicited to electrical field stimulation and on bronchodilator responses to vasoactive intestinal peptide (the putative transmitter of these nerves), in guinea-pig trachea. Capsaicin pretreatment enhanced the relaxation responses induced by both electrical field stimulation and vasoactive intestinal peptide, whereas these responses were not significantly increased in vehicle-pretreated or in untreated animals. The bronchodilator response to isoprenaline was unaffected by capsaicin pretreatment. Sensory neuropeptide depletion therefore augments both inhibitory non-adrenergic, non-cholinergic responses and responses to exogenous vasoactive intestinal peptide, suggesting an effect on vasoactive intestinal peptide receptors.</description><subject>Air breathing</subject><subject>Airway Resistance - drug effects</subject><subject>Airways (guinea-pig)</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Capsaicin</subject><subject>Capsaicin - pharmacology</subject><subject>Electric Stimulation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Guinea Pigs</subject><subject>In Vitro Techniques</subject><subject>Isoproterenol - pharmacology</subject><subject>Male</subject><subject>Neuropeptides - deficiency</subject><subject>Non-adrenergic, non-cholinergic (NANC) responses (inhibitory)</subject><subject>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</subject><subject>Sensation - physiology</subject><subject>Trachea - innervation</subject><subject>Vasoactive Intestinal Peptide - pharmacology</subject><subject>Vertebrates: respiratory system</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9v1DAQxa0K1C6l36CVcgGBRGDsxEnmgoQq_lWVOABny7EnW7dZO7WzRfvtSTarcisna2Z-7431hrFzDu858OoDAC9zgYhvEN4iVKLJr47Yijc15lBz8YytHpET9iKlWwCQKOQxOxZQI4dixe5-kk8h7jJP8YEyS0NPows-G8JIfnR6pJQ5f-NaN-6x4HNtI0342pl3-9rchN4tjcVmVmTr7dTT-eDWmXbxj96ll-x5p_tEZ4f3lP3-8vnX5bf8-sfX75efrnNTSBzzTnayIKuxAc7BlLqaamEtlEa3RkoQIIqmBbBSFq3mxrRdSRKrojJl25rilL1efIcY7reURrVxyVDfa09hm1QDAmsoq_-CXNaIsmwmsFxAE0NKkTo1RLfRcac4qPkYak5azUkrBLU_hrqaZBcH_227IfsoOqQ_zV8d5joZ3XdRe-PSP28UtWhwXv9x4WhK7cFRVMk48oasi2RGZYN7-iN_ASUeqB8</recordid><startdate>19900810</startdate><enddate>19900810</enddate><creator>Stretton, C.David</creator><creator>Belvisi, Maria G.</creator><creator>Barnes, Peter J.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19900810</creationdate><title>Sensory nerve depletion potentiates inhibitory non-adrenergic, non-cholinergic nerves in guinea-pig airways</title><author>Stretton, C.David ; Belvisi, Maria G. ; Barnes, Peter J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-f5f53eda980110c4a6f532dd04cabc55020238b00d553ba1ccbf4e59636c4bbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Air breathing</topic><topic>Airway Resistance - drug effects</topic><topic>Airways (guinea-pig)</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Capsaicin</topic><topic>Capsaicin - pharmacology</topic><topic>Electric Stimulation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Guinea Pigs</topic><topic>In Vitro Techniques</topic><topic>Isoproterenol - pharmacology</topic><topic>Male</topic><topic>Neuropeptides - deficiency</topic><topic>Non-adrenergic, non-cholinergic (NANC) responses (inhibitory)</topic><topic>Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics</topic><topic>Sensation - physiology</topic><topic>Trachea - innervation</topic><topic>Vasoactive Intestinal Peptide - pharmacology</topic><topic>Vertebrates: respiratory system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stretton, C.David</creatorcontrib><creatorcontrib>Belvisi, Maria G.</creatorcontrib><creatorcontrib>Barnes, Peter J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stretton, C.David</au><au>Belvisi, Maria G.</au><au>Barnes, Peter J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sensory nerve depletion potentiates inhibitory non-adrenergic, non-cholinergic nerves in guinea-pig airways</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1990-08-10</date><risdate>1990</risdate><volume>184</volume><issue>2</issue><spage>333</spage><epage>337</epage><pages>333-337</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><coden>EJPHAZ</coden><abstract>The effect of sensory neuropeptide depletion by systemac capsaicin pretreatment was studied both on inhibitory non-adrenergic, non-cholinergic responses elicited to electrical field stimulation and on bronchodilator responses to vasoactive intestinal peptide (the putative transmitter of these nerves), in guinea-pig trachea. Capsaicin pretreatment enhanced the relaxation responses induced by both electrical field stimulation and vasoactive intestinal peptide, whereas these responses were not significantly increased in vehicle-pretreated or in untreated animals. The bronchodilator response to isoprenaline was unaffected by capsaicin pretreatment. Sensory neuropeptide depletion therefore augments both inhibitory non-adrenergic, non-cholinergic responses and responses to exogenous vasoactive intestinal peptide, suggesting an effect on vasoactive intestinal peptide receptors.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>2079103</pmid><doi>10.1016/0014-2999(90)90628-J</doi><tpages>5</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1990-08, Vol.184 (2), p.333-337 |
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| subjects | Air breathing Airway Resistance - drug effects Airways (guinea-pig) Animals Biological and medical sciences Capsaicin Capsaicin - pharmacology Electric Stimulation Fundamental and applied biological sciences. Psychology Guinea Pigs In Vitro Techniques Isoproterenol - pharmacology Male Neuropeptides - deficiency Non-adrenergic, non-cholinergic (NANC) responses (inhibitory) Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics Sensation - physiology Trachea - innervation Vasoactive Intestinal Peptide - pharmacology Vertebrates: respiratory system |
| title | Sensory nerve depletion potentiates inhibitory non-adrenergic, non-cholinergic nerves in guinea-pig airways |
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