Antiviral efficacy of pyrazofurin against selected rna viruses

The antibiotic pyrazofurin, 3-(β-D-ribofuranosyl)-4-hydroxypyrazole-5-carboxamide, markedly inhibited the in vitro replication of a number of RNA viruses including Rift Valley fever (RVF), Venezuelan equine encephalomyelitis (VEE), Sandfly, Pichinde, Lassa and LCM virus. Plaque formation was reduced...

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Veröffentlicht in:	Antiviral research 1982-12, Vol.2 (6), p.331-337
Hauptverfasser:	Canonico, P.G., Jahrling, P.B., Pannier, W.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - pharmacology Arenaviridae - drug effects Dose-Response Relationship, Drug Drug Evaluation, Preclinical Encephalitis Virus, Venezuelan Equine - drug effects Female Guinea Pigs Male Mice Phlebovirus - drug effects Ribavirin - pharmacology Ribonucleosides - pharmacology Rift Valley fever virus - drug effects RNA Viruses - drug effects Viral Plaque Assay Virus Diseases - drug therapy Yellow fever virus - drug effects
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