Hypoglycaemic effect of Momordica charantia extracts
Abstract The hypoglycaemic effect of orally administered extracts of fruits of cultivated MOMORDICA CHARANTIA (karela) was examined in normal and strep-tozotocin diabetic mice. In normal mice, an aqueous extract (A) lowered the glycaemic response to both oral and intraperitoneal glucose, without alt...
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| Veröffentlicht in: | Planta medica 1990-10, Vol.56 (5), p.426-429 |
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| container_title | Planta medica |
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| creator | Day, C Cartwright, T Provost, J Bailey, C.J |
| description | Abstract
The hypoglycaemic effect of orally administered extracts of fruits of cultivated MOMORDICA CHARANTIA (karela) was examined in normal and strep-tozotocin diabetic mice. In normal mice, an aqueous extract (A) lowered the glycaemic response to both oral and intraperitoneal glucose, without altering the insulin response. This aqueous extract (A) and the residue after alkaline chloroform extraction (B) reduced the hyper-glycaemia in diabetic mice at 1 hour. Material recovered by acid water wash of the chloroform extract remaining after an alkaline water wash (D) produced a more slowly generated hypoglycaemic effect. The results suggest that orally administered karela extracts lower glucose concentrations independently of intestinal glucose absorption and involve an extrapancreatic effect. Two types of hypoglycaemic substances with different time dependent effects are indicated. |
| doi_str_mv | 10.1055/s-2006-961003 |
| format | Article |
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The hypoglycaemic effect of orally administered extracts of fruits of cultivated MOMORDICA CHARANTIA (karela) was examined in normal and strep-tozotocin diabetic mice. In normal mice, an aqueous extract (A) lowered the glycaemic response to both oral and intraperitoneal glucose, without altering the insulin response. This aqueous extract (A) and the residue after alkaline chloroform extraction (B) reduced the hyper-glycaemia in diabetic mice at 1 hour. Material recovered by acid water wash of the chloroform extract remaining after an alkaline water wash (D) produced a more slowly generated hypoglycaemic effect. The results suggest that orally administered karela extracts lower glucose concentrations independently of intestinal glucose absorption and involve an extrapancreatic effect. Two types of hypoglycaemic substances with different time dependent effects are indicated.</description><identifier>ISSN: 0032-0943</identifier><identifier>EISSN: 1439-0221</identifier><identifier>DOI: 10.1055/s-2006-961003</identifier><identifier>PMID: 2077547</identifier><identifier>CODEN: PLMEAA</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; Biological and medical sciences ; Blood Glucose - drug effects ; Diabetes Mellitus, Experimental - blood ; Diabetes Mellitus, Experimental - drug therapy ; General pharmacology ; Glucose Tolerance Test ; hypoglycemic agents ; Hypoglycemic Agents - therapeutic use ; Insulin - blood ; Male ; Medical sciences ; Mice ; Momordica charantia ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; plant extracts ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use</subject><ispartof>Planta medica, 1990-10, Vol.56 (5), p.426-429</ispartof><rights>Georg Thieme Verlag Stuttgart · New York</rights><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2943-c6f0be76cb34f06127f1d77fc08834e2b13dfd0630447acb9f30a7a72f2dda423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2006-961003.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3015,3016,27922,27923,54557</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19384665$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2077547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Day, C</creatorcontrib><creatorcontrib>Cartwright, T</creatorcontrib><creatorcontrib>Provost, J</creatorcontrib><creatorcontrib>Bailey, C.J</creatorcontrib><title>Hypoglycaemic effect of Momordica charantia extracts</title><title>Planta medica</title><addtitle>Planta Med</addtitle><description>Abstract
The hypoglycaemic effect of orally administered extracts of fruits of cultivated MOMORDICA CHARANTIA (karela) was examined in normal and strep-tozotocin diabetic mice. In normal mice, an aqueous extract (A) lowered the glycaemic response to both oral and intraperitoneal glucose, without altering the insulin response. This aqueous extract (A) and the residue after alkaline chloroform extraction (B) reduced the hyper-glycaemia in diabetic mice at 1 hour. Material recovered by acid water wash of the chloroform extract remaining after an alkaline water wash (D) produced a more slowly generated hypoglycaemic effect. The results suggest that orally administered karela extracts lower glucose concentrations independently of intestinal glucose absorption and involve an extrapancreatic effect. Two types of hypoglycaemic substances with different time dependent effects are indicated.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - drug effects</subject><subject>Diabetes Mellitus, Experimental - blood</subject><subject>Diabetes Mellitus, Experimental - drug therapy</subject><subject>General pharmacology</subject><subject>Glucose Tolerance Test</subject><subject>hypoglycemic agents</subject><subject>Hypoglycemic Agents - therapeutic use</subject><subject>Insulin - blood</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Momordica charantia</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>plant extracts</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kT1PwzAQhi0EKqUwMiKywETg_JG4GVEFFKmIATpbF8duUyV1sVOJ_ntcpYKJ6aS7R-_pniPkksI9hSx7CCkDyNMipwD8iAyp4EUKjNFjMowdlkIh-Ck5C2EFQEUBMCADBlJmQg6JmO42btHsNJq21omx1ugucTZ5c63zVa0x0Uv0uO5qTMx351F34ZycWGyCuTjUEZk_P31Opuns_eV18jhLNYs7U51bKI3MdcmFhZwyaWklpdUwHnNhWEl5ZSvIOQghUZeF5YASJbOsqlAwPiK3fe7Gu6-tCZ1q66BN0-DauG1QY2BFRos9mPag9i4Eb6za-LpFv1MU1N6SCmpvSfWWIn91CN6Wral-6YOWOL85zDFobGy8X9fhL7TgY5HnWeTueq5b1qY1auW2fh2N_Lv2usctOoULHyPnHwwoByrjYyTjP3kZhOE</recordid><startdate>199010</startdate><enddate>199010</enddate><creator>Day, C</creator><creator>Cartwright, T</creator><creator>Provost, J</creator><creator>Bailey, C.J</creator><general>Thieme</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199010</creationdate><title>Hypoglycaemic effect of Momordica charantia extracts</title><author>Day, C ; Cartwright, T ; Provost, J ; Bailey, C.J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2943-c6f0be76cb34f06127f1d77fc08834e2b13dfd0630447acb9f30a7a72f2dda423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - drug effects</topic><topic>Diabetes Mellitus, Experimental - blood</topic><topic>Diabetes Mellitus, Experimental - drug therapy</topic><topic>General pharmacology</topic><topic>Glucose Tolerance Test</topic><topic>hypoglycemic agents</topic><topic>Hypoglycemic Agents - therapeutic use</topic><topic>Insulin - blood</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Momordica charantia</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>plant extracts</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Day, C</creatorcontrib><creatorcontrib>Cartwright, T</creatorcontrib><creatorcontrib>Provost, J</creatorcontrib><creatorcontrib>Bailey, C.J</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Day, C</au><au>Cartwright, T</au><au>Provost, J</au><au>Bailey, C.J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypoglycaemic effect of Momordica charantia extracts</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1990-10</date><risdate>1990</risdate><volume>56</volume><issue>5</issue><spage>426</spage><epage>429</epage><pages>426-429</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><coden>PLMEAA</coden><abstract>Abstract
The hypoglycaemic effect of orally administered extracts of fruits of cultivated MOMORDICA CHARANTIA (karela) was examined in normal and strep-tozotocin diabetic mice. In normal mice, an aqueous extract (A) lowered the glycaemic response to both oral and intraperitoneal glucose, without altering the insulin response. This aqueous extract (A) and the residue after alkaline chloroform extraction (B) reduced the hyper-glycaemia in diabetic mice at 1 hour. Material recovered by acid water wash of the chloroform extract remaining after an alkaline water wash (D) produced a more slowly generated hypoglycaemic effect. The results suggest that orally administered karela extracts lower glucose concentrations independently of intestinal glucose absorption and involve an extrapancreatic effect. Two types of hypoglycaemic substances with different time dependent effects are indicated.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>2077547</pmid><doi>10.1055/s-2006-961003</doi><tpages>4</tpages></addata></record> |
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| ispartof | Planta medica, 1990-10, Vol.56 (5), p.426-429 |
| issn | 0032-0943 1439-0221 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Animals Biological and medical sciences Blood Glucose - drug effects Diabetes Mellitus, Experimental - blood Diabetes Mellitus, Experimental - drug therapy General pharmacology Glucose Tolerance Test hypoglycemic agents Hypoglycemic Agents - therapeutic use Insulin - blood Male Medical sciences Mice Momordica charantia Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Extracts - pharmacology Plant Extracts - therapeutic use |
| title | Hypoglycaemic effect of Momordica charantia extracts |
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