Quantitative effect of H-2-linked gene(s) on antibody response to human gamma-globulin
H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F 2 interline hybrids, the gene...
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| Veröffentlicht in: | Immunology letters 1982-11, Vol.5 (5), p.273-276 |
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| container_end_page | 276 |
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| container_issue | 5 |
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| container_title | Immunology letters |
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| creator | Heumann, Anne-Marie Mouton, Denise Biozzi, Guido |
| description | H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F
2 interline hybrids, the gene(s) linked to the H-2 phenotype of H mice has a “low” effect, and the gene(s) linked to the H-2 phenotype of L mice a “high” effect on the magnitude of antibody response to HGG. In H and L mice, the non-specific polygenic control of antibody responsiveness is able to compensate/counteract the inverse effect of HGG-specific H-2-linked gene(s) since the usual interline difference is observed. |
| doi_str_mv | 10.1016/0165-2478(82)90111-0 |
| format | Article |
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2 interline hybrids, the gene(s) linked to the H-2 phenotype of H mice has a “low” effect, and the gene(s) linked to the H-2 phenotype of L mice a “high” effect on the magnitude of antibody response to HGG. In H and L mice, the non-specific polygenic control of antibody responsiveness is able to compensate/counteract the inverse effect of HGG-specific H-2-linked gene(s) since the usual interline difference is observed.</description><identifier>ISSN: 0165-2478</identifier><identifier>EISSN: 1879-0542</identifier><identifier>DOI: 10.1016/0165-2478(82)90111-0</identifier><identifier>PMID: 6186600</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; antibody ; Antibody Formation ; Crosses, Genetic ; Dose-Response Relationship, Immunologic ; Female ; gamma-Globulins - immunology ; Genes, Dominant ; Genetic Linkage ; H-2 Antigens - genetics ; H-2 Antigens - immunology ; H-2 locus polygenic regulation ; human gamma-globulin ; Humans ; Male ; Mice ; Mice, Inbred Strains</subject><ispartof>Immunology letters, 1982-11, Vol.5 (5), p.273-276</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-3488baed8859143280d858b163208b858b0c7cf00500af1bf4731441c27da14b3</citedby><cites>FETCH-LOGICAL-c357t-3488baed8859143280d858b163208b858b0c7cf00500af1bf4731441c27da14b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-2478(82)90111-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6186600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heumann, Anne-Marie</creatorcontrib><creatorcontrib>Mouton, Denise</creatorcontrib><creatorcontrib>Biozzi, Guido</creatorcontrib><title>Quantitative effect of H-2-linked gene(s) on antibody response to human gamma-globulin</title><title>Immunology letters</title><addtitle>Immunol Lett</addtitle><description>H-2-linked gene(s) have been found to play a role in the quantitative regulation of response to human gamma-globulin (HGG) in mice selected for high or low antibody responsiveness to sheep erythrocytes. Unexpectedly, in a random genetically heterogeneous population of F
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2 interline hybrids, the gene(s) linked to the H-2 phenotype of H mice has a “low” effect, and the gene(s) linked to the H-2 phenotype of L mice a “high” effect on the magnitude of antibody response to HGG. In H and L mice, the non-specific polygenic control of antibody responsiveness is able to compensate/counteract the inverse effect of HGG-specific H-2-linked gene(s) since the usual interline difference is observed.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>6186600</pmid><doi>10.1016/0165-2478(82)90111-0</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0165-2478 |
| ispartof | Immunology letters, 1982-11, Vol.5 (5), p.273-276 |
| issn | 0165-2478 1879-0542 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80293743 |
| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Animals antibody Antibody Formation Crosses, Genetic Dose-Response Relationship, Immunologic Female gamma-Globulins - immunology Genes, Dominant Genetic Linkage H-2 Antigens - genetics H-2 Antigens - immunology H-2 locus polygenic regulation human gamma-globulin Humans Male Mice Mice, Inbred Strains |
| title | Quantitative effect of H-2-linked gene(s) on antibody response to human gamma-globulin |
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