Effect of exercise on propranolol pharmacokinetics
The effect of submaximal exercise on the pharmacokinetics of low dose intravenous propranolol was studied in 15 healthy human subjects. There was a wide individual variation in the results for each subject and a large difference in the degree of changes with exercise. The effect of exercise on the p...
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| Veröffentlicht in: | European journal of clinical pharmacology 1990-01, Vol.39 (4), p.391-394 |
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| container_title | European journal of clinical pharmacology |
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| creator | FRANK, S SOMANI, S. M KOHNLE, M |
| description | The effect of submaximal exercise on the pharmacokinetics of low dose intravenous propranolol was studied in 15 healthy human subjects. There was a wide individual variation in the results for each subject and a large difference in the degree of changes with exercise. The effect of exercise on the pharmacokinetics of propranolol, a flow limited drug, is marked but variable. This phenomenon may have profound effects on patients taking the drug regularly who exercise intermittently and drug doses may have to be adjusted. |
| doi_str_mv | 10.1007/BF00315416 |
| format | Article |
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This phenomenon may have profound effects on patients taking the drug regularly who exercise intermittently and drug doses may have to be adjusted.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00315416</identifier><identifier>PMID: 2076723</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Adult ; Antihypertensive agents ; Biological and medical sciences ; Cardiovascular system ; Half-Life ; Humans ; Injections, Intravenous ; Male ; Medical sciences ; Pharmacology. 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This phenomenon may have profound effects on patients taking the drug regularly who exercise intermittently and drug doses may have to be adjusted.</description><subject>Adult</subject><subject>Antihypertensive agents</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Injections, Intravenous</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Physical Exertion</topic><topic>Propranolol - administration & dosage</topic><topic>Propranolol - blood</topic><topic>Propranolol - pharmacokinetics</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>FRANK, S</creatorcontrib><creatorcontrib>SOMANI, S. M</creatorcontrib><creatorcontrib>KOHNLE, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>FRANK, S</au><au>SOMANI, S. 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| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1990-01, Vol.39 (4), p.391-394 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_80291715 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Antihypertensive agents Biological and medical sciences Cardiovascular system Half-Life Humans Injections, Intravenous Male Medical sciences Pharmacology. Drug treatments Physical Exertion Propranolol - administration & dosage Propranolol - blood Propranolol - pharmacokinetics Time Factors |
| title | Effect of exercise on propranolol pharmacokinetics |
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