Detection of Pericine, a New CNS-active Indole Alkaloid from Picralima nitida Cell Suspension Culture by Opiate Receptor Binding Studies
Abstract Successive fractionation of a crude methanolic extract of cultured PICRALIMA NITIDA cells accompanied by opiate receptor binding studies led to the detection and isolation of two compounds with opioid activity. The substances were identified as the indole alkaloids pericalline and pericine,...
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| Veröffentlicht in: | Planta medica 1982-12, Vol.46 (12), p.210-214 |
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| container_issue | 12 |
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| container_title | Planta medica |
| container_volume | 46 |
| creator | Arens, H. Borbe, H. O. Ulbrich, B. Stöckigt, J. |
| description | Abstract
Successive fractionation of a crude methanolic extract of cultured PICRALIMA NITIDA cells accompanied by opiate receptor binding studies led to the detection and isolation of two compounds with opioid activity. The substances were identified as the indole alkaloids pericalline and pericine, the latter, as yet, not described. Half-maximal inhibition (IC
50
) by the alkaloids was 2.3 µMol/l for pericalline and 0.6 µMol/l for pericine, values which lie within the micromolar range of the weak analgetic codeine (IC
50
: 3.6 µMol/l). |
| doi_str_mv | 10.1055/s-2007-971216 |
| format | Article |
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Successive fractionation of a crude methanolic extract of cultured PICRALIMA NITIDA cells accompanied by opiate receptor binding studies led to the detection and isolation of two compounds with opioid activity. The substances were identified as the indole alkaloids pericalline and pericine, the latter, as yet, not described. Half-maximal inhibition (IC
50
) by the alkaloids was 2.3 µMol/l for pericalline and 0.6 µMol/l for pericine, values which lie within the micromolar range of the weak analgetic codeine (IC
50
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Successive fractionation of a crude methanolic extract of cultured PICRALIMA NITIDA cells accompanied by opiate receptor binding studies led to the detection and isolation of two compounds with opioid activity. The substances were identified as the indole alkaloids pericalline and pericine, the latter, as yet, not described. Half-maximal inhibition (IC
50
) by the alkaloids was 2.3 µMol/l for pericalline and 0.6 µMol/l for pericine, values which lie within the micromolar range of the weak analgetic codeine (IC
50
: 3.6 µMol/l).</description><subject>Alkaloids - analysis</subject><subject>Animals</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Plants - analysis</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Opioid - drug effects</subject><issn>0032-0943</issn><issn>1439-0221</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kMFu1DAURS0EKtPCkiWSV6xqsJ3YsZclQKlUtRUDa8tjv4BLYqe2A-of8NlkNCN2rN7iXh29exB6xehbRoV4VwintCO6Y5zJJ2jD2kYTyjl7ijaUNpxQ3TbP0Wkp95SyVlN6gk4k10q13Qb9-QAVXA0p4jTgO8jBhQjn2OIb-I37my2xa_oL8FX0aQR8Mf60YwoeDzlN-C64bMcwWRxDDd7iHsYRb5cyQyx7Zr-MdcmAd4_4dg62Av4CDuaaMn4fog_xO97WxQcoL9CzwY4FXh7vGfr26ePX_jO5vr286i-uiWu4qMRzGJh0VHSWDtp3kkHXsYZpxVzHleCMa6E85zuvpZe2bQQVXkiwXjE5qOYMvTlw55weFijVTKG49W0bIS3FKMqVVnJfJIeiy6mUDIOZ87o0PxpGzd68KWZv3hzMr_3XR_Cym8D_ax9Vr_n5Ia8_Akxg7tOS47r0P7i_2dCL7g</recordid><startdate>198212</startdate><enddate>198212</enddate><creator>Arens, H.</creator><creator>Borbe, H. O.</creator><creator>Ulbrich, B.</creator><creator>Stöckigt, J.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198212</creationdate><title>Detection of Pericine, a New CNS-active Indole Alkaloid from Picralima nitida Cell Suspension Culture by Opiate Receptor Binding Studies</title><author>Arens, H. ; Borbe, H. O. ; Ulbrich, B. ; Stöckigt, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c325t-d2ef16c057a0f9d761e77131981c7285212958d22bd96d6a43505d56ead816f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Alkaloids - analysis</topic><topic>Animals</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Plants - analysis</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Opioid - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arens, H.</creatorcontrib><creatorcontrib>Borbe, H. O.</creatorcontrib><creatorcontrib>Ulbrich, B.</creatorcontrib><creatorcontrib>Stöckigt, J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Planta medica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arens, H.</au><au>Borbe, H. O.</au><au>Ulbrich, B.</au><au>Stöckigt, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of Pericine, a New CNS-active Indole Alkaloid from Picralima nitida Cell Suspension Culture by Opiate Receptor Binding Studies</atitle><jtitle>Planta medica</jtitle><addtitle>Planta Med</addtitle><date>1982-12</date><risdate>1982</risdate><volume>46</volume><issue>12</issue><spage>210</spage><epage>214</epage><pages>210-214</pages><issn>0032-0943</issn><eissn>1439-0221</eissn><abstract>Abstract
Successive fractionation of a crude methanolic extract of cultured PICRALIMA NITIDA cells accompanied by opiate receptor binding studies led to the detection and isolation of two compounds with opioid activity. The substances were identified as the indole alkaloids pericalline and pericine, the latter, as yet, not described. Half-maximal inhibition (IC
50
) by the alkaloids was 2.3 µMol/l for pericalline and 0.6 µMol/l for pericine, values which lie within the micromolar range of the weak analgetic codeine (IC
50
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| fulltext | fulltext |
| identifier | ISSN: 0032-0943 |
| ispartof | Planta medica, 1982-12, Vol.46 (12), p.210-214 |
| issn | 0032-0943 1439-0221 |
| language | eng |
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| source | MEDLINE; Thieme Connect Journals |
| subjects | Alkaloids - analysis Animals In Vitro Techniques Male Plants - analysis Rats Rats, Inbred Strains Receptors, Opioid - drug effects |
| title | Detection of Pericine, a New CNS-active Indole Alkaloid from Picralima nitida Cell Suspension Culture by Opiate Receptor Binding Studies |
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