Peptide inhibition of morphine-induced dopaminergic supersensitivity
Injection of the peptide cyclo(Leu-Gly) into rats prior to chronic exposure to morphine, inhibits: 1) the development of analgesic tolerance; 2) some signs of physical dependence; and, 3) morphine-induced increases in behavioral responses to dopamine agonists. Although there was no change in the tot...
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| Veröffentlicht in: | Life sciences (1973) 1982-11, Vol.31 (20), p.2287-2290 |
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| container_title | Life sciences (1973) |
| container_volume | 31 |
| creator | Ritzmann, R.F. Lee, J.M. Fields, J.Z. |
| description | Injection of the peptide cyclo(Leu-Gly) into rats prior to chronic exposure to morphine, inhibits: 1) the development of analgesic tolerance; 2) some signs of physical dependence; and, 3) morphine-induced increases in behavioral responses to dopamine agonists. Although there was no change in the total number of high affinity striatal dopamine receptors, chronic morphine treatment did increase the affinity of the ligand at the receptor. The peptide blocked not only the affinity change, but the increased behavioral response to apomorphine as well. These behavioral changes correlate significantly with the neurochemical changes in dopamine receptors following chronic morphine treatment. Therefore, some of the pharmacological efforts of morphine may be mediated by changes in CNS dopamine receptors and that the peptides may act by inhibiting these neurochemical changes. |
| doi_str_mv | 10.1016/0024-3205(82)90139-4 |
| format | Article |
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Although there was no change in the total number of high affinity striatal dopamine receptors, chronic morphine treatment did increase the affinity of the ligand at the receptor. The peptide blocked not only the affinity change, but the increased behavioral response to apomorphine as well. These behavioral changes correlate significantly with the neurochemical changes in dopamine receptors following chronic morphine treatment. Therefore, some of the pharmacological efforts of morphine may be mediated by changes in CNS dopamine receptors and that the peptides may act by inhibiting these neurochemical changes.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(82)90139-4</identifier><identifier>PMID: 6891737</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Analgesia ; Animals ; Corpus Striatum - drug effects ; Corpus Striatum - physiology ; Dipeptides - pharmacology ; Dopamine - physiology ; Humans ; Hypothalamus - drug effects ; Hypothalamus - physiology ; Male ; Morphine - pharmacology ; Neuropeptides ; Peptides, Cyclic ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine - drug effects ; Receptors, Dopamine - metabolism ; Spiperone - metabolism ; Stereotyped Behavior - drug effects</subject><ispartof>Life sciences (1973), 1982-11, Vol.31 (20), p.2287-2290</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-a23ffe853296d488b8b660f1c1df0408caf6a4e99574052ce9e558fe89f54b7d3</citedby><cites>FETCH-LOGICAL-c272t-a23ffe853296d488b8b660f1c1df0408caf6a4e99574052ce9e558fe89f54b7d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(82)90139-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6891737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ritzmann, R.F.</creatorcontrib><creatorcontrib>Lee, J.M.</creatorcontrib><creatorcontrib>Fields, J.Z.</creatorcontrib><title>Peptide inhibition of morphine-induced dopaminergic supersensitivity</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Injection of the peptide cyclo(Leu-Gly) into rats prior to chronic exposure to morphine, inhibits: 1) the development of analgesic tolerance; 2) some signs of physical dependence; and, 3) morphine-induced increases in behavioral responses to dopamine agonists. 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Therefore, some of the pharmacological efforts of morphine may be mediated by changes in CNS dopamine receptors and that the peptides may act by inhibiting these neurochemical changes.</description><subject>Analgesia</subject><subject>Animals</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - physiology</subject><subject>Dipeptides - pharmacology</subject><subject>Dopamine - physiology</subject><subject>Humans</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - physiology</subject><subject>Male</subject><subject>Morphine - pharmacology</subject><subject>Neuropeptides</subject><subject>Peptides, Cyclic</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Receptors, Dopamine - metabolism</subject><subject>Spiperone - metabolism</subject><subject>Stereotyped Behavior - drug effects</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAQx4Mo6_r4Bgo9iR6qSZqkyUUQ37CgBz2HNpm4kW1Tk3Zhv71dd9mjp4H5P4b5IXRG8DXBRNxgTFleUMwvJb1SmBQqZ3toSmSpciwKso-mO8shOkrpG2PMeVlM0ERIRcqinKKHd-h6byHz7dzXvvehzYLLmhC7uW8h960dDNjMhq5qxkX88iZLQwcxQZtG_9L3qxN04KpFgtPtPEafT48f9y_57O359f5ulhta0j6vaOEcSF5QJSyTspa1ENgRQ6zDDEtTOVExUIqXDHNqQAHnckwox1ld2uIYXWx6uxh-Bki9bnwysFhULYQhaYmplJKI0cg2RhNDShGc7qJvqrjSBOs1PL0mo9dktKT6D55mY-x82z_UDdhdaEtr1G83OoxPLj1EnYyHduTjI5he2-D_P_ALhZ1-3g</recordid><startdate>19821101</startdate><enddate>19821101</enddate><creator>Ritzmann, R.F.</creator><creator>Lee, J.M.</creator><creator>Fields, J.Z.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19821101</creationdate><title>Peptide inhibition of morphine-induced dopaminergic supersensitivity</title><author>Ritzmann, R.F. ; Lee, J.M. ; Fields, J.Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-a23ffe853296d488b8b660f1c1df0408caf6a4e99574052ce9e558fe89f54b7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Analgesia</topic><topic>Animals</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - physiology</topic><topic>Dipeptides - pharmacology</topic><topic>Dopamine - physiology</topic><topic>Humans</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - physiology</topic><topic>Male</topic><topic>Morphine - pharmacology</topic><topic>Neuropeptides</topic><topic>Peptides, Cyclic</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Receptors, Dopamine - metabolism</topic><topic>Spiperone - metabolism</topic><topic>Stereotyped Behavior - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ritzmann, R.F.</creatorcontrib><creatorcontrib>Lee, J.M.</creatorcontrib><creatorcontrib>Fields, J.Z.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ritzmann, R.F.</au><au>Lee, J.M.</au><au>Fields, J.Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Peptide inhibition of morphine-induced dopaminergic supersensitivity</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1982-11-01</date><risdate>1982</risdate><volume>31</volume><issue>20</issue><spage>2287</spage><epage>2290</epage><pages>2287-2290</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Injection of the peptide cyclo(Leu-Gly) into rats prior to chronic exposure to morphine, inhibits: 1) the development of analgesic tolerance; 2) some signs of physical dependence; and, 3) morphine-induced increases in behavioral responses to dopamine agonists. 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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Analgesia Animals Corpus Striatum - drug effects Corpus Striatum - physiology Dipeptides - pharmacology Dopamine - physiology Humans Hypothalamus - drug effects Hypothalamus - physiology Male Morphine - pharmacology Neuropeptides Peptides, Cyclic Rats Rats, Inbred Strains Receptors, Dopamine - drug effects Receptors, Dopamine - metabolism Spiperone - metabolism Stereotyped Behavior - drug effects |
| title | Peptide inhibition of morphine-induced dopaminergic supersensitivity |
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